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The Use of Green Leaf Membranes to Promote Appetite Control, Suppress Hedonic Hunger and Loose Body Weight.

Erlanson-Albertsson C, Albertsson PÅ - Plant Foods Hum Nutr (2015)

Bottom Line: We have found that certain components from green leaves, the thylakoids, when given orally have a similar rationale in inducing the release of several gut hormones at the same time.The mechanism is a reduced rate of intestinal lipid hydrolysis, allowing the lipolytic products to reach the distal intestine and release satiety hormones.Using thylakoids is a novel strategy for treatment and prevention of obesity.

View Article: PubMed Central - PubMed

Affiliation: Department of Experimental Medical Science, Appetite Control Unit, Bio-Medical Centre (BMC), B11, Lund University, Sölvegatan 19, SE 221 84, Lund, Sweden, charlotte.erlanson-albertsson@med.lu.se.

ABSTRACT
On-going research aims at answering the question, which satiety signal is the most potent or which combination of satiety signals is the most potent to stop eating. There is also an aim at finding certain food items or food additives that could be used to specifically reduce food intake therapeutically. Therapeutic attempts to normalize body weight and glycaemia with single agents alone have generally been disappointing. The success of bariatric surgery illustrates the rationale of using several hormones to treat obesity and type-2-diabetes. We have found that certain components from green leaves, the thylakoids, when given orally have a similar rationale in inducing the release of several gut hormones at the same time. In this way satiety is promoted and hunger suppressed, leading to loss of body weight and body fat. The mechanism is a reduced rate of intestinal lipid hydrolysis, allowing the lipolytic products to reach the distal intestine and release satiety hormones. The thylakoids also regulate glucose uptake in the intestine and influences microbiota composition in the intestine in a prebiotic direction. Using thylakoids is a novel strategy for treatment and prevention of obesity.

No MeSH data available.


Related in: MedlinePlus

The mechanism of action of thylakoids in appetite regulation. When thylakoids are consumed they will retard fat digestion, and release the gut hormones cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1). These hormones promote satiety and suppress hunger, in particular hedonic hunger i.e., urge for sweet and fat. The thylakoids also change the bacteria in the intestine in a prebiotic way, increasing the strains Lactobacillus reuteri. With these effects thylakoids are important for prevention of obesity and diabetes
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Fig5: The mechanism of action of thylakoids in appetite regulation. When thylakoids are consumed they will retard fat digestion, and release the gut hormones cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1). These hormones promote satiety and suppress hunger, in particular hedonic hunger i.e., urge for sweet and fat. The thylakoids also change the bacteria in the intestine in a prebiotic way, increasing the strains Lactobacillus reuteri. With these effects thylakoids are important for prevention of obesity and diabetes

Mentions: In conclusion, thylakoids when added to food are powerful promoters of satiety and suppressors of hunger, in particular hedonic hunger. The mechanism is a late satiety, by the use of the whole intestine for digestion of food. In this way satiety hormones are released from the distal intestine, the ileal break, providing information to the brain that satiety has been achieved and a reduced urge for snacking. Since snacking is an important contributor to the global epidemic of obesity today, the consumption of thylakoids may aid in the prevention of this epidemic. The effects of thylakoids are summarized in Fig. 5.Fig. 5


The Use of Green Leaf Membranes to Promote Appetite Control, Suppress Hedonic Hunger and Loose Body Weight.

Erlanson-Albertsson C, Albertsson PÅ - Plant Foods Hum Nutr (2015)

The mechanism of action of thylakoids in appetite regulation. When thylakoids are consumed they will retard fat digestion, and release the gut hormones cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1). These hormones promote satiety and suppress hunger, in particular hedonic hunger i.e., urge for sweet and fat. The thylakoids also change the bacteria in the intestine in a prebiotic way, increasing the strains Lactobacillus reuteri. With these effects thylakoids are important for prevention of obesity and diabetes
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4539357&req=5

Fig5: The mechanism of action of thylakoids in appetite regulation. When thylakoids are consumed they will retard fat digestion, and release the gut hormones cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1). These hormones promote satiety and suppress hunger, in particular hedonic hunger i.e., urge for sweet and fat. The thylakoids also change the bacteria in the intestine in a prebiotic way, increasing the strains Lactobacillus reuteri. With these effects thylakoids are important for prevention of obesity and diabetes
Mentions: In conclusion, thylakoids when added to food are powerful promoters of satiety and suppressors of hunger, in particular hedonic hunger. The mechanism is a late satiety, by the use of the whole intestine for digestion of food. In this way satiety hormones are released from the distal intestine, the ileal break, providing information to the brain that satiety has been achieved and a reduced urge for snacking. Since snacking is an important contributor to the global epidemic of obesity today, the consumption of thylakoids may aid in the prevention of this epidemic. The effects of thylakoids are summarized in Fig. 5.Fig. 5

Bottom Line: We have found that certain components from green leaves, the thylakoids, when given orally have a similar rationale in inducing the release of several gut hormones at the same time.The mechanism is a reduced rate of intestinal lipid hydrolysis, allowing the lipolytic products to reach the distal intestine and release satiety hormones.Using thylakoids is a novel strategy for treatment and prevention of obesity.

View Article: PubMed Central - PubMed

Affiliation: Department of Experimental Medical Science, Appetite Control Unit, Bio-Medical Centre (BMC), B11, Lund University, Sölvegatan 19, SE 221 84, Lund, Sweden, charlotte.erlanson-albertsson@med.lu.se.

ABSTRACT
On-going research aims at answering the question, which satiety signal is the most potent or which combination of satiety signals is the most potent to stop eating. There is also an aim at finding certain food items or food additives that could be used to specifically reduce food intake therapeutically. Therapeutic attempts to normalize body weight and glycaemia with single agents alone have generally been disappointing. The success of bariatric surgery illustrates the rationale of using several hormones to treat obesity and type-2-diabetes. We have found that certain components from green leaves, the thylakoids, when given orally have a similar rationale in inducing the release of several gut hormones at the same time. In this way satiety is promoted and hunger suppressed, leading to loss of body weight and body fat. The mechanism is a reduced rate of intestinal lipid hydrolysis, allowing the lipolytic products to reach the distal intestine and release satiety hormones. The thylakoids also regulate glucose uptake in the intestine and influences microbiota composition in the intestine in a prebiotic direction. Using thylakoids is a novel strategy for treatment and prevention of obesity.

No MeSH data available.


Related in: MedlinePlus