Limits...
The Use of Green Leaf Membranes to Promote Appetite Control, Suppress Hedonic Hunger and Loose Body Weight.

Erlanson-Albertsson C, Albertsson PÅ - Plant Foods Hum Nutr (2015)

Bottom Line: We have found that certain components from green leaves, the thylakoids, when given orally have a similar rationale in inducing the release of several gut hormones at the same time.The mechanism is a reduced rate of intestinal lipid hydrolysis, allowing the lipolytic products to reach the distal intestine and release satiety hormones.Using thylakoids is a novel strategy for treatment and prevention of obesity.

View Article: PubMed Central - PubMed

Affiliation: Department of Experimental Medical Science, Appetite Control Unit, Bio-Medical Centre (BMC), B11, Lund University, Sölvegatan 19, SE 221 84, Lund, Sweden, charlotte.erlanson-albertsson@med.lu.se.

ABSTRACT
On-going research aims at answering the question, which satiety signal is the most potent or which combination of satiety signals is the most potent to stop eating. There is also an aim at finding certain food items or food additives that could be used to specifically reduce food intake therapeutically. Therapeutic attempts to normalize body weight and glycaemia with single agents alone have generally been disappointing. The success of bariatric surgery illustrates the rationale of using several hormones to treat obesity and type-2-diabetes. We have found that certain components from green leaves, the thylakoids, when given orally have a similar rationale in inducing the release of several gut hormones at the same time. In this way satiety is promoted and hunger suppressed, leading to loss of body weight and body fat. The mechanism is a reduced rate of intestinal lipid hydrolysis, allowing the lipolytic products to reach the distal intestine and release satiety hormones. The thylakoids also regulate glucose uptake in the intestine and influences microbiota composition in the intestine in a prebiotic direction. Using thylakoids is a novel strategy for treatment and prevention of obesity.

No MeSH data available.


Related in: MedlinePlus

Suppressed urge for sweet and release of GLP-1 (glucagon-like peptide 1) with and without the consumption of thylakoids. Overweight women were served a breakfast at time point zero with or without 5 g of thylakoids and a lunch at time point 360 min. Urge for sweet was measured through VAS as well as GLP-1 through blood sampling. The subjects receiving thylakoids had a significantly suppressed urge for sweet and increased release of GLP-1 even after 90 days of body weight loss compared to control [41]
© Copyright Policy - OpenAccess
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4539357&req=5

Fig4: Suppressed urge for sweet and release of GLP-1 (glucagon-like peptide 1) with and without the consumption of thylakoids. Overweight women were served a breakfast at time point zero with or without 5 g of thylakoids and a lunch at time point 360 min. Urge for sweet was measured through VAS as well as GLP-1 through blood sampling. The subjects receiving thylakoids had a significantly suppressed urge for sweet and increased release of GLP-1 even after 90 days of body weight loss compared to control [41]

Mentions: Another explanation for the increased satiety by thylakoids may be the release of CCK and GLP-1. Release of CCK has been postulated to occur only after fat- and protein-rich meals. Even a carbohydrate-rich meal was found to raise CCK levels [44]. Release of GLP-1 was significantly stimulated by thylakoids during consumption of a breakfast in overweight women (Fig. 4) [41]. GLP-1 is a satiety hormone, produced by intestinal cells in response to carbohydrate and fat. In particular fatty acids are potent releasers of GLP-1. GLP-1 is a hormone that is being developed as an anti-obesity drug. In our hands thylakoids caused the endogenous release of GLP-1, which is an easier and more physiological way to enhance GLP-1 levels to achieve satiety and energy balance.Fig. 4


The Use of Green Leaf Membranes to Promote Appetite Control, Suppress Hedonic Hunger and Loose Body Weight.

Erlanson-Albertsson C, Albertsson PÅ - Plant Foods Hum Nutr (2015)

Suppressed urge for sweet and release of GLP-1 (glucagon-like peptide 1) with and without the consumption of thylakoids. Overweight women were served a breakfast at time point zero with or without 5 g of thylakoids and a lunch at time point 360 min. Urge for sweet was measured through VAS as well as GLP-1 through blood sampling. The subjects receiving thylakoids had a significantly suppressed urge for sweet and increased release of GLP-1 even after 90 days of body weight loss compared to control [41]
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4539357&req=5

Fig4: Suppressed urge for sweet and release of GLP-1 (glucagon-like peptide 1) with and without the consumption of thylakoids. Overweight women were served a breakfast at time point zero with or without 5 g of thylakoids and a lunch at time point 360 min. Urge for sweet was measured through VAS as well as GLP-1 through blood sampling. The subjects receiving thylakoids had a significantly suppressed urge for sweet and increased release of GLP-1 even after 90 days of body weight loss compared to control [41]
Mentions: Another explanation for the increased satiety by thylakoids may be the release of CCK and GLP-1. Release of CCK has been postulated to occur only after fat- and protein-rich meals. Even a carbohydrate-rich meal was found to raise CCK levels [44]. Release of GLP-1 was significantly stimulated by thylakoids during consumption of a breakfast in overweight women (Fig. 4) [41]. GLP-1 is a satiety hormone, produced by intestinal cells in response to carbohydrate and fat. In particular fatty acids are potent releasers of GLP-1. GLP-1 is a hormone that is being developed as an anti-obesity drug. In our hands thylakoids caused the endogenous release of GLP-1, which is an easier and more physiological way to enhance GLP-1 levels to achieve satiety and energy balance.Fig. 4

Bottom Line: We have found that certain components from green leaves, the thylakoids, when given orally have a similar rationale in inducing the release of several gut hormones at the same time.The mechanism is a reduced rate of intestinal lipid hydrolysis, allowing the lipolytic products to reach the distal intestine and release satiety hormones.Using thylakoids is a novel strategy for treatment and prevention of obesity.

View Article: PubMed Central - PubMed

Affiliation: Department of Experimental Medical Science, Appetite Control Unit, Bio-Medical Centre (BMC), B11, Lund University, Sölvegatan 19, SE 221 84, Lund, Sweden, charlotte.erlanson-albertsson@med.lu.se.

ABSTRACT
On-going research aims at answering the question, which satiety signal is the most potent or which combination of satiety signals is the most potent to stop eating. There is also an aim at finding certain food items or food additives that could be used to specifically reduce food intake therapeutically. Therapeutic attempts to normalize body weight and glycaemia with single agents alone have generally been disappointing. The success of bariatric surgery illustrates the rationale of using several hormones to treat obesity and type-2-diabetes. We have found that certain components from green leaves, the thylakoids, when given orally have a similar rationale in inducing the release of several gut hormones at the same time. In this way satiety is promoted and hunger suppressed, leading to loss of body weight and body fat. The mechanism is a reduced rate of intestinal lipid hydrolysis, allowing the lipolytic products to reach the distal intestine and release satiety hormones. The thylakoids also regulate glucose uptake in the intestine and influences microbiota composition in the intestine in a prebiotic direction. Using thylakoids is a novel strategy for treatment and prevention of obesity.

No MeSH data available.


Related in: MedlinePlus