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The Use of Green Leaf Membranes to Promote Appetite Control, Suppress Hedonic Hunger and Loose Body Weight.

Erlanson-Albertsson C, Albertsson PÅ - Plant Foods Hum Nutr (2015)

Bottom Line: We have found that certain components from green leaves, the thylakoids, when given orally have a similar rationale in inducing the release of several gut hormones at the same time.The mechanism is a reduced rate of intestinal lipid hydrolysis, allowing the lipolytic products to reach the distal intestine and release satiety hormones.Using thylakoids is a novel strategy for treatment and prevention of obesity.

View Article: PubMed Central - PubMed

Affiliation: Department of Experimental Medical Science, Appetite Control Unit, Bio-Medical Centre (BMC), B11, Lund University, Sölvegatan 19, SE 221 84, Lund, Sweden, charlotte.erlanson-albertsson@med.lu.se.

ABSTRACT
On-going research aims at answering the question, which satiety signal is the most potent or which combination of satiety signals is the most potent to stop eating. There is also an aim at finding certain food items or food additives that could be used to specifically reduce food intake therapeutically. Therapeutic attempts to normalize body weight and glycaemia with single agents alone have generally been disappointing. The success of bariatric surgery illustrates the rationale of using several hormones to treat obesity and type-2-diabetes. We have found that certain components from green leaves, the thylakoids, when given orally have a similar rationale in inducing the release of several gut hormones at the same time. In this way satiety is promoted and hunger suppressed, leading to loss of body weight and body fat. The mechanism is a reduced rate of intestinal lipid hydrolysis, allowing the lipolytic products to reach the distal intestine and release satiety hormones. The thylakoids also regulate glucose uptake in the intestine and influences microbiota composition in the intestine in a prebiotic direction. Using thylakoids is a novel strategy for treatment and prevention of obesity.

No MeSH data available.


Related in: MedlinePlus

The release of CCK following a meal with and without thylakoids in human. With thylakoids there was a late release of CCK in addition to the early release. In control there was only an early release of CCK. Thus, thylakoids induce the release of the satiety hormone CCK during a longer period, being important for prevention of intermeal snacking [31]
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Fig3: The release of CCK following a meal with and without thylakoids in human. With thylakoids there was a late release of CCK in addition to the early release. In control there was only an early release of CCK. Thus, thylakoids induce the release of the satiety hormone CCK during a longer period, being important for prevention of intermeal snacking [31]

Mentions: In human a high-fat meal was served with increasing concentrations of thylakoids, from 5 to 50 g [31]. The thylakoids were mixed with rapeseed oil (26 g) and cashew-nuts (25 g), lime, salt and basil and was eaten as a pesto sauce on bread with tomatoes. The percentage fat was 65 energy %, carbohydrate 25 E% and protein10 E%. With such a meal CCK was released in a dose-dependent way, significantly different from control at time point 4 h and 6 h after the start of meal. The control meal rendered an optimal CCK release at time point 30 min after the start of meal, while with thylakoids there was an early release of CCK at time point 30 min and a new peak after 4 h (Fig. 3).Fig. 3


The Use of Green Leaf Membranes to Promote Appetite Control, Suppress Hedonic Hunger and Loose Body Weight.

Erlanson-Albertsson C, Albertsson PÅ - Plant Foods Hum Nutr (2015)

The release of CCK following a meal with and without thylakoids in human. With thylakoids there was a late release of CCK in addition to the early release. In control there was only an early release of CCK. Thus, thylakoids induce the release of the satiety hormone CCK during a longer period, being important for prevention of intermeal snacking [31]
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4539357&req=5

Fig3: The release of CCK following a meal with and without thylakoids in human. With thylakoids there was a late release of CCK in addition to the early release. In control there was only an early release of CCK. Thus, thylakoids induce the release of the satiety hormone CCK during a longer period, being important for prevention of intermeal snacking [31]
Mentions: In human a high-fat meal was served with increasing concentrations of thylakoids, from 5 to 50 g [31]. The thylakoids were mixed with rapeseed oil (26 g) and cashew-nuts (25 g), lime, salt and basil and was eaten as a pesto sauce on bread with tomatoes. The percentage fat was 65 energy %, carbohydrate 25 E% and protein10 E%. With such a meal CCK was released in a dose-dependent way, significantly different from control at time point 4 h and 6 h after the start of meal. The control meal rendered an optimal CCK release at time point 30 min after the start of meal, while with thylakoids there was an early release of CCK at time point 30 min and a new peak after 4 h (Fig. 3).Fig. 3

Bottom Line: We have found that certain components from green leaves, the thylakoids, when given orally have a similar rationale in inducing the release of several gut hormones at the same time.The mechanism is a reduced rate of intestinal lipid hydrolysis, allowing the lipolytic products to reach the distal intestine and release satiety hormones.Using thylakoids is a novel strategy for treatment and prevention of obesity.

View Article: PubMed Central - PubMed

Affiliation: Department of Experimental Medical Science, Appetite Control Unit, Bio-Medical Centre (BMC), B11, Lund University, Sölvegatan 19, SE 221 84, Lund, Sweden, charlotte.erlanson-albertsson@med.lu.se.

ABSTRACT
On-going research aims at answering the question, which satiety signal is the most potent or which combination of satiety signals is the most potent to stop eating. There is also an aim at finding certain food items or food additives that could be used to specifically reduce food intake therapeutically. Therapeutic attempts to normalize body weight and glycaemia with single agents alone have generally been disappointing. The success of bariatric surgery illustrates the rationale of using several hormones to treat obesity and type-2-diabetes. We have found that certain components from green leaves, the thylakoids, when given orally have a similar rationale in inducing the release of several gut hormones at the same time. In this way satiety is promoted and hunger suppressed, leading to loss of body weight and body fat. The mechanism is a reduced rate of intestinal lipid hydrolysis, allowing the lipolytic products to reach the distal intestine and release satiety hormones. The thylakoids also regulate glucose uptake in the intestine and influences microbiota composition in the intestine in a prebiotic direction. Using thylakoids is a novel strategy for treatment and prevention of obesity.

No MeSH data available.


Related in: MedlinePlus