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The Use of Green Leaf Membranes to Promote Appetite Control, Suppress Hedonic Hunger and Loose Body Weight.

Erlanson-Albertsson C, Albertsson PÅ - Plant Foods Hum Nutr (2015)

Bottom Line: We have found that certain components from green leaves, the thylakoids, when given orally have a similar rationale in inducing the release of several gut hormones at the same time.The mechanism is a reduced rate of intestinal lipid hydrolysis, allowing the lipolytic products to reach the distal intestine and release satiety hormones.Using thylakoids is a novel strategy for treatment and prevention of obesity.

View Article: PubMed Central - PubMed

Affiliation: Department of Experimental Medical Science, Appetite Control Unit, Bio-Medical Centre (BMC), B11, Lund University, Sölvegatan 19, SE 221 84, Lund, Sweden, charlotte.erlanson-albertsson@med.lu.se.

ABSTRACT
On-going research aims at answering the question, which satiety signal is the most potent or which combination of satiety signals is the most potent to stop eating. There is also an aim at finding certain food items or food additives that could be used to specifically reduce food intake therapeutically. Therapeutic attempts to normalize body weight and glycaemia with single agents alone have generally been disappointing. The success of bariatric surgery illustrates the rationale of using several hormones to treat obesity and type-2-diabetes. We have found that certain components from green leaves, the thylakoids, when given orally have a similar rationale in inducing the release of several gut hormones at the same time. In this way satiety is promoted and hunger suppressed, leading to loss of body weight and body fat. The mechanism is a reduced rate of intestinal lipid hydrolysis, allowing the lipolytic products to reach the distal intestine and release satiety hormones. The thylakoids also regulate glucose uptake in the intestine and influences microbiota composition in the intestine in a prebiotic direction. Using thylakoids is a novel strategy for treatment and prevention of obesity.

No MeSH data available.


Related in: MedlinePlus

Thylakoids and fat digestion. Thylakoids inhibit lipase/colipase activity in a dose-dependent way [18]. The inhibition is due to the binding of thylakoids to the triglyceride interface, thus covering the substrate to be hydrolysed [18, 19]. The thylakoids also bind the pancreatic lipase/colipase complex [20]. The hydrolysis of the oil droplet thus occurs more slowly. Intestinal enzymes gradually break down the thylakoids, which allows fat digestion to be completed. Therefore there is no steatorrea
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Fig2: Thylakoids and fat digestion. Thylakoids inhibit lipase/colipase activity in a dose-dependent way [18]. The inhibition is due to the binding of thylakoids to the triglyceride interface, thus covering the substrate to be hydrolysed [18, 19]. The thylakoids also bind the pancreatic lipase/colipase complex [20]. The hydrolysis of the oil droplet thus occurs more slowly. Intestinal enzymes gradually break down the thylakoids, which allows fat digestion to be completed. Therefore there is no steatorrea

Mentions: Our first discovery on the effect of thylakoids was a powerful inhibition of the pancreatic lipase/colipase catalysed hydrolysis of fat (Fig. 2) [18]. Pancreatic lipase with its protein cofactor colipase is the main enzyme responsible for hydrolysis of dietary fat in the intestine [21]. Lack of either lipase or colipase causes impaired fat digestion and steatorrea [22]. The idea that a reduced rate of fat digestion would affect appetite was clear from colipase knock out mice, who in their heterozygous form had a more slowly growth [23]. This idea was further promoted by the discovery of a compound that inhibited pancreatic lipase/colipase and at the same time reduced food intake in rat after oral administration [24].Fig. 2


The Use of Green Leaf Membranes to Promote Appetite Control, Suppress Hedonic Hunger and Loose Body Weight.

Erlanson-Albertsson C, Albertsson PÅ - Plant Foods Hum Nutr (2015)

Thylakoids and fat digestion. Thylakoids inhibit lipase/colipase activity in a dose-dependent way [18]. The inhibition is due to the binding of thylakoids to the triglyceride interface, thus covering the substrate to be hydrolysed [18, 19]. The thylakoids also bind the pancreatic lipase/colipase complex [20]. The hydrolysis of the oil droplet thus occurs more slowly. Intestinal enzymes gradually break down the thylakoids, which allows fat digestion to be completed. Therefore there is no steatorrea
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4539357&req=5

Fig2: Thylakoids and fat digestion. Thylakoids inhibit lipase/colipase activity in a dose-dependent way [18]. The inhibition is due to the binding of thylakoids to the triglyceride interface, thus covering the substrate to be hydrolysed [18, 19]. The thylakoids also bind the pancreatic lipase/colipase complex [20]. The hydrolysis of the oil droplet thus occurs more slowly. Intestinal enzymes gradually break down the thylakoids, which allows fat digestion to be completed. Therefore there is no steatorrea
Mentions: Our first discovery on the effect of thylakoids was a powerful inhibition of the pancreatic lipase/colipase catalysed hydrolysis of fat (Fig. 2) [18]. Pancreatic lipase with its protein cofactor colipase is the main enzyme responsible for hydrolysis of dietary fat in the intestine [21]. Lack of either lipase or colipase causes impaired fat digestion and steatorrea [22]. The idea that a reduced rate of fat digestion would affect appetite was clear from colipase knock out mice, who in their heterozygous form had a more slowly growth [23]. This idea was further promoted by the discovery of a compound that inhibited pancreatic lipase/colipase and at the same time reduced food intake in rat after oral administration [24].Fig. 2

Bottom Line: We have found that certain components from green leaves, the thylakoids, when given orally have a similar rationale in inducing the release of several gut hormones at the same time.The mechanism is a reduced rate of intestinal lipid hydrolysis, allowing the lipolytic products to reach the distal intestine and release satiety hormones.Using thylakoids is a novel strategy for treatment and prevention of obesity.

View Article: PubMed Central - PubMed

Affiliation: Department of Experimental Medical Science, Appetite Control Unit, Bio-Medical Centre (BMC), B11, Lund University, Sölvegatan 19, SE 221 84, Lund, Sweden, charlotte.erlanson-albertsson@med.lu.se.

ABSTRACT
On-going research aims at answering the question, which satiety signal is the most potent or which combination of satiety signals is the most potent to stop eating. There is also an aim at finding certain food items or food additives that could be used to specifically reduce food intake therapeutically. Therapeutic attempts to normalize body weight and glycaemia with single agents alone have generally been disappointing. The success of bariatric surgery illustrates the rationale of using several hormones to treat obesity and type-2-diabetes. We have found that certain components from green leaves, the thylakoids, when given orally have a similar rationale in inducing the release of several gut hormones at the same time. In this way satiety is promoted and hunger suppressed, leading to loss of body weight and body fat. The mechanism is a reduced rate of intestinal lipid hydrolysis, allowing the lipolytic products to reach the distal intestine and release satiety hormones. The thylakoids also regulate glucose uptake in the intestine and influences microbiota composition in the intestine in a prebiotic direction. Using thylakoids is a novel strategy for treatment and prevention of obesity.

No MeSH data available.


Related in: MedlinePlus