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The Use of Green Leaf Membranes to Promote Appetite Control, Suppress Hedonic Hunger and Loose Body Weight.

Erlanson-Albertsson C, Albertsson PÅ - Plant Foods Hum Nutr (2015)

Bottom Line: We have found that certain components from green leaves, the thylakoids, when given orally have a similar rationale in inducing the release of several gut hormones at the same time.The mechanism is a reduced rate of intestinal lipid hydrolysis, allowing the lipolytic products to reach the distal intestine and release satiety hormones.Using thylakoids is a novel strategy for treatment and prevention of obesity.

View Article: PubMed Central - PubMed

Affiliation: Department of Experimental Medical Science, Appetite Control Unit, Bio-Medical Centre (BMC), B11, Lund University, Sölvegatan 19, SE 221 84, Lund, Sweden, charlotte.erlanson-albertsson@med.lu.se.

ABSTRACT
On-going research aims at answering the question, which satiety signal is the most potent or which combination of satiety signals is the most potent to stop eating. There is also an aim at finding certain food items or food additives that could be used to specifically reduce food intake therapeutically. Therapeutic attempts to normalize body weight and glycaemia with single agents alone have generally been disappointing. The success of bariatric surgery illustrates the rationale of using several hormones to treat obesity and type-2-diabetes. We have found that certain components from green leaves, the thylakoids, when given orally have a similar rationale in inducing the release of several gut hormones at the same time. In this way satiety is promoted and hunger suppressed, leading to loss of body weight and body fat. The mechanism is a reduced rate of intestinal lipid hydrolysis, allowing the lipolytic products to reach the distal intestine and release satiety hormones. The thylakoids also regulate glucose uptake in the intestine and influences microbiota composition in the intestine in a prebiotic direction. Using thylakoids is a novel strategy for treatment and prevention of obesity.

No MeSH data available.


Related in: MedlinePlus

A plant cell consists of chloroplasts, where the photosynthesis takes place. The cell is surrounded by a cell wall, resistant to digestion by humans. A vacuole with water takes up 80 % of the volume of a cell. The thylakoids are membranes building up the photosynthetic apparatus in the chloroplast. The thylakoids consists of galactolipids, proteins, pigments, vitamins and antioxidants
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Fig1: A plant cell consists of chloroplasts, where the photosynthesis takes place. The cell is surrounded by a cell wall, resistant to digestion by humans. A vacuole with water takes up 80 % of the volume of a cell. The thylakoids are membranes building up the photosynthetic apparatus in the chloroplast. The thylakoids consists of galactolipids, proteins, pigments, vitamins and antioxidants

Mentions: Thylakoids are the membranes in the chloroplasts of green leaves responsible for the light reaction in photosynthesis (Fig. 1) [5, 6]. They are probably the most complex of biological membranes and organized into continuous paired membranes having different composition and function. The thylakoids contain over 100 different proteins, both intrinsic and extrinsic, together with membrane lipids and pigments. The thylakoids are located in chloroplasts of green leaves and at a higher concentration in dark green leaves compared to light green leaves. Characteristic of the proteins is that they are membrane spanning, which means that they are hydrophobic and attract to hydrophobic surfaces like lipids. The thylakoids have an iso-electric pH at 4,7 [7]. This means that they are positively charged at a pH below 4,7 and negatively charged above pH 4,7. In the stomach the pH is close to 2,0 during fasting conditions. During a meal the pH of gastric contents increases up to 6–7 depending on the food components and remains much above pH 2 until most of the meal is emptied. In the intestine pH is like-wise around 6,5 in the lumen. This means that the thylakoids are negatively charged and can bind positively charged ions. In the lumen of the intestine thylakoids form large swollen structures that adhere to the mucosal surface [8]. The mucosal surface of the intestine pH has an acidic pH, around 5,3 [9]. The thylakoids thus are rather isoelectric at the mucosal surface and hence easily adsorb to this, as has been demonstrated [8].Fig. 1


The Use of Green Leaf Membranes to Promote Appetite Control, Suppress Hedonic Hunger and Loose Body Weight.

Erlanson-Albertsson C, Albertsson PÅ - Plant Foods Hum Nutr (2015)

A plant cell consists of chloroplasts, where the photosynthesis takes place. The cell is surrounded by a cell wall, resistant to digestion by humans. A vacuole with water takes up 80 % of the volume of a cell. The thylakoids are membranes building up the photosynthetic apparatus in the chloroplast. The thylakoids consists of galactolipids, proteins, pigments, vitamins and antioxidants
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4539357&req=5

Fig1: A plant cell consists of chloroplasts, where the photosynthesis takes place. The cell is surrounded by a cell wall, resistant to digestion by humans. A vacuole with water takes up 80 % of the volume of a cell. The thylakoids are membranes building up the photosynthetic apparatus in the chloroplast. The thylakoids consists of galactolipids, proteins, pigments, vitamins and antioxidants
Mentions: Thylakoids are the membranes in the chloroplasts of green leaves responsible for the light reaction in photosynthesis (Fig. 1) [5, 6]. They are probably the most complex of biological membranes and organized into continuous paired membranes having different composition and function. The thylakoids contain over 100 different proteins, both intrinsic and extrinsic, together with membrane lipids and pigments. The thylakoids are located in chloroplasts of green leaves and at a higher concentration in dark green leaves compared to light green leaves. Characteristic of the proteins is that they are membrane spanning, which means that they are hydrophobic and attract to hydrophobic surfaces like lipids. The thylakoids have an iso-electric pH at 4,7 [7]. This means that they are positively charged at a pH below 4,7 and negatively charged above pH 4,7. In the stomach the pH is close to 2,0 during fasting conditions. During a meal the pH of gastric contents increases up to 6–7 depending on the food components and remains much above pH 2 until most of the meal is emptied. In the intestine pH is like-wise around 6,5 in the lumen. This means that the thylakoids are negatively charged and can bind positively charged ions. In the lumen of the intestine thylakoids form large swollen structures that adhere to the mucosal surface [8]. The mucosal surface of the intestine pH has an acidic pH, around 5,3 [9]. The thylakoids thus are rather isoelectric at the mucosal surface and hence easily adsorb to this, as has been demonstrated [8].Fig. 1

Bottom Line: We have found that certain components from green leaves, the thylakoids, when given orally have a similar rationale in inducing the release of several gut hormones at the same time.The mechanism is a reduced rate of intestinal lipid hydrolysis, allowing the lipolytic products to reach the distal intestine and release satiety hormones.Using thylakoids is a novel strategy for treatment and prevention of obesity.

View Article: PubMed Central - PubMed

Affiliation: Department of Experimental Medical Science, Appetite Control Unit, Bio-Medical Centre (BMC), B11, Lund University, Sölvegatan 19, SE 221 84, Lund, Sweden, charlotte.erlanson-albertsson@med.lu.se.

ABSTRACT
On-going research aims at answering the question, which satiety signal is the most potent or which combination of satiety signals is the most potent to stop eating. There is also an aim at finding certain food items or food additives that could be used to specifically reduce food intake therapeutically. Therapeutic attempts to normalize body weight and glycaemia with single agents alone have generally been disappointing. The success of bariatric surgery illustrates the rationale of using several hormones to treat obesity and type-2-diabetes. We have found that certain components from green leaves, the thylakoids, when given orally have a similar rationale in inducing the release of several gut hormones at the same time. In this way satiety is promoted and hunger suppressed, leading to loss of body weight and body fat. The mechanism is a reduced rate of intestinal lipid hydrolysis, allowing the lipolytic products to reach the distal intestine and release satiety hormones. The thylakoids also regulate glucose uptake in the intestine and influences microbiota composition in the intestine in a prebiotic direction. Using thylakoids is a novel strategy for treatment and prevention of obesity.

No MeSH data available.


Related in: MedlinePlus