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Evaluation of Stability and Biological Activity of Solid Nanodispersion of Lambda-Cyhalothrin.

Cui B, Feng L, Pan Z, Yu M, Zeng Z, Sun C, Zhao X, Wang Y, Cui H - PLoS ONE (2015)

Bottom Line: In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods.The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability.The formulation is free of organic solvents, and the use of surfactant is reduced.

View Article: PubMed Central - PubMed

Affiliation: Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.

ABSTRACT
Pesticides are essential agrochemicals used to protect plants from diseases, pests and weeds. However, the formulation defects of conventional pesticides cause food toxicity and ecological environmental problems. In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods. The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability. The formulation is free of organic solvents, and the use of surfactant is reduced. Therefore, the application of the solid nanodispersion in crop production will improve efficacy and reduce the occurrence of both pesticide residues in food and environmental pollution from pesticides.

No MeSH data available.


Related in: MedlinePlus

Stability of the lambda-cyhalothrin solid nanodispersion for (a) different storage times and (b) different storage temperatures.PDI: polydispersity index.
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pone.0135953.g007: Stability of the lambda-cyhalothrin solid nanodispersion for (a) different storage times and (b) different storage temperatures.PDI: polydispersity index.

Mentions: A stability test of the solid nanodispersion was conducted according to CIPAC MT 46 and GB/T 19136–2003. Fig 7a shows the change in particle size over a 14-day storage period at 25°C. Within five days, the particle size increased from 21.7 nm to 57.8 nm, and it then remained almost constant up to 14 days. In addition, the suspensibility and wettability of the nanodispersion after 14 days of storage were 99.4% and 23 s, respectively. This result illustrates that, after storage, the solid nanodispersion of lambda-cyhalothrin remained its good dispersibility and wettability relative to the WP formulation [53]. As shown in Fig 7b, the particle size of the nanodispersions increased to some extent but remained less than 85 nm after 14 days of storage at low (0°C), room (25°C) or high (54°C) temperatures. A similar particle growth phenomenon during storage has also been observed in other nano-formulations, such as microemulsions and nanosuspensions, due to Ostwald ripening [20,38,54]. The above results indicate that the nanodispersion has excellent storage stability. Moreover, the solid nanodispersion showed better stability under low and room-temperature storage than under high- temperature storage. One possible reason is the occurrence of nanoparticle aggregation and an increase in particle size at 54°C, which is above the melting point of lambda-cyhalothrin.


Evaluation of Stability and Biological Activity of Solid Nanodispersion of Lambda-Cyhalothrin.

Cui B, Feng L, Pan Z, Yu M, Zeng Z, Sun C, Zhao X, Wang Y, Cui H - PLoS ONE (2015)

Stability of the lambda-cyhalothrin solid nanodispersion for (a) different storage times and (b) different storage temperatures.PDI: polydispersity index.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4539193&req=5

pone.0135953.g007: Stability of the lambda-cyhalothrin solid nanodispersion for (a) different storage times and (b) different storage temperatures.PDI: polydispersity index.
Mentions: A stability test of the solid nanodispersion was conducted according to CIPAC MT 46 and GB/T 19136–2003. Fig 7a shows the change in particle size over a 14-day storage period at 25°C. Within five days, the particle size increased from 21.7 nm to 57.8 nm, and it then remained almost constant up to 14 days. In addition, the suspensibility and wettability of the nanodispersion after 14 days of storage were 99.4% and 23 s, respectively. This result illustrates that, after storage, the solid nanodispersion of lambda-cyhalothrin remained its good dispersibility and wettability relative to the WP formulation [53]. As shown in Fig 7b, the particle size of the nanodispersions increased to some extent but remained less than 85 nm after 14 days of storage at low (0°C), room (25°C) or high (54°C) temperatures. A similar particle growth phenomenon during storage has also been observed in other nano-formulations, such as microemulsions and nanosuspensions, due to Ostwald ripening [20,38,54]. The above results indicate that the nanodispersion has excellent storage stability. Moreover, the solid nanodispersion showed better stability under low and room-temperature storage than under high- temperature storage. One possible reason is the occurrence of nanoparticle aggregation and an increase in particle size at 54°C, which is above the melting point of lambda-cyhalothrin.

Bottom Line: In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods.The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability.The formulation is free of organic solvents, and the use of surfactant is reduced.

View Article: PubMed Central - PubMed

Affiliation: Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.

ABSTRACT
Pesticides are essential agrochemicals used to protect plants from diseases, pests and weeds. However, the formulation defects of conventional pesticides cause food toxicity and ecological environmental problems. In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods. The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability. The formulation is free of organic solvents, and the use of surfactant is reduced. Therefore, the application of the solid nanodispersion in crop production will improve efficacy and reduce the occurrence of both pesticide residues in food and environmental pollution from pesticides.

No MeSH data available.


Related in: MedlinePlus