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Evaluation of Stability and Biological Activity of Solid Nanodispersion of Lambda-Cyhalothrin.

Cui B, Feng L, Pan Z, Yu M, Zeng Z, Sun C, Zhao X, Wang Y, Cui H - PLoS ONE (2015)

Bottom Line: In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods.The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability.The formulation is free of organic solvents, and the use of surfactant is reduced.

View Article: PubMed Central - PubMed

Affiliation: Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.

ABSTRACT
Pesticides are essential agrochemicals used to protect plants from diseases, pests and weeds. However, the formulation defects of conventional pesticides cause food toxicity and ecological environmental problems. In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods. The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability. The formulation is free of organic solvents, and the use of surfactant is reduced. Therefore, the application of the solid nanodispersion in crop production will improve efficacy and reduce the occurrence of both pesticide residues in food and environmental pollution from pesticides.

No MeSH data available.


Related in: MedlinePlus

XRD patterns of pure components in the nano-formulation and lambda-cyhalothrin solid nanodispersion.SDS: 1-dodecanesulfonic acid sodium salt; MRES: maleic rosin-polyoxypropylene-polyoxyethylene ether sulfonate.
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pone.0135953.g006: XRD patterns of pure components in the nano-formulation and lambda-cyhalothrin solid nanodispersion.SDS: 1-dodecanesulfonic acid sodium salt; MRES: maleic rosin-polyoxypropylene-polyoxyethylene ether sulfonate.

Mentions: As shown in Fig 6, the XRD pattern of the solid nanodispersion presented characteristic peaks of crystalline lambda-cyhalothrin at 12.8°, 15.6°, 18.9°, 20.9° and 26.0°. In addition, diffraction peaks of the pesticide at 18.9° and 24.9° (labelled by red arrows) caused an increase of the corresponding peak intensity of the solid nanodispersion compared with the sucrose pattern. These results indicate that the crystallinity of the pesticide was preserved during the nanosizing process. In contrast, some wet-milling and high pressure homogenization processes may change material’s structure, even inducing progressive amorphization due to the large amount of heat and energy generated during the processes [23,39,40]. Furthermore, it was found that the first five intense peaks of the solid nanodispersion were mainly derived from crystalline sucrose. A reasonable explanation was the high content of sucrose in the mixture. According to the literature [41,42], the crystalline state improves stability during storage compared with the amorphous form, which increases molecular mobility and leads to aggregation issues.


Evaluation of Stability and Biological Activity of Solid Nanodispersion of Lambda-Cyhalothrin.

Cui B, Feng L, Pan Z, Yu M, Zeng Z, Sun C, Zhao X, Wang Y, Cui H - PLoS ONE (2015)

XRD patterns of pure components in the nano-formulation and lambda-cyhalothrin solid nanodispersion.SDS: 1-dodecanesulfonic acid sodium salt; MRES: maleic rosin-polyoxypropylene-polyoxyethylene ether sulfonate.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4539193&req=5

pone.0135953.g006: XRD patterns of pure components in the nano-formulation and lambda-cyhalothrin solid nanodispersion.SDS: 1-dodecanesulfonic acid sodium salt; MRES: maleic rosin-polyoxypropylene-polyoxyethylene ether sulfonate.
Mentions: As shown in Fig 6, the XRD pattern of the solid nanodispersion presented characteristic peaks of crystalline lambda-cyhalothrin at 12.8°, 15.6°, 18.9°, 20.9° and 26.0°. In addition, diffraction peaks of the pesticide at 18.9° and 24.9° (labelled by red arrows) caused an increase of the corresponding peak intensity of the solid nanodispersion compared with the sucrose pattern. These results indicate that the crystallinity of the pesticide was preserved during the nanosizing process. In contrast, some wet-milling and high pressure homogenization processes may change material’s structure, even inducing progressive amorphization due to the large amount of heat and energy generated during the processes [23,39,40]. Furthermore, it was found that the first five intense peaks of the solid nanodispersion were mainly derived from crystalline sucrose. A reasonable explanation was the high content of sucrose in the mixture. According to the literature [41,42], the crystalline state improves stability during storage compared with the amorphous form, which increases molecular mobility and leads to aggregation issues.

Bottom Line: In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods.The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability.The formulation is free of organic solvents, and the use of surfactant is reduced.

View Article: PubMed Central - PubMed

Affiliation: Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.

ABSTRACT
Pesticides are essential agrochemicals used to protect plants from diseases, pests and weeds. However, the formulation defects of conventional pesticides cause food toxicity and ecological environmental problems. In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods. The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability. The formulation is free of organic solvents, and the use of surfactant is reduced. Therefore, the application of the solid nanodispersion in crop production will improve efficacy and reduce the occurrence of both pesticide residues in food and environmental pollution from pesticides.

No MeSH data available.


Related in: MedlinePlus