Limits...
Evaluation of Stability and Biological Activity of Solid Nanodispersion of Lambda-Cyhalothrin.

Cui B, Feng L, Pan Z, Yu M, Zeng Z, Sun C, Zhao X, Wang Y, Cui H - PLoS ONE (2015)

Bottom Line: In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods.The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability.The formulation is free of organic solvents, and the use of surfactant is reduced.

View Article: PubMed Central - PubMed

Affiliation: Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.

ABSTRACT
Pesticides are essential agrochemicals used to protect plants from diseases, pests and weeds. However, the formulation defects of conventional pesticides cause food toxicity and ecological environmental problems. In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods. The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability. The formulation is free of organic solvents, and the use of surfactant is reduced. Therefore, the application of the solid nanodispersion in crop production will improve efficacy and reduce the occurrence of both pesticide residues in food and environmental pollution from pesticides.

No MeSH data available.


Related in: MedlinePlus

SEM photograph of lambda-cyhalothrin nanoparticles.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4539193&req=5

pone.0135953.g005: SEM photograph of lambda-cyhalothrin nanoparticles.

Mentions: As an example, the solid nanodispersion containing 8% (w/w) lambda-cyhalothrin with 0.4% (w/w) surfactant was subjected to a detailed characterization. The mean size and D90 of the re-dispersed aqueous solution of the formulation measured by DLS were 21.7±0.1 nm and 82.8±0.9 nm, respectively. According to the SEM image, the nanoparticles were spherical, and the particle size was in the range of 25 nm to 85 nm (Fig 5), agreeing well with the DLS results. The particles of the solid nanodispersion are significantly smaller than the particles obtained by the solidification of microemulsions and nanosuspensions prepared by high pressure homogenization [20,26,33–35]. This result proves that melt-emulsification combined with high-speed shearing is an effective method for constructing pesticide nano-formulations. A suspension with an absolute zeta potential value higher than 30 mV is always considered stable [36]. However, good stability of a suspension with lower zeta potential can also be obtained when the surfactant provides steric stabilization in addition to electrostatic repulsion [20,37,38]. In this study, the zeta potential and pH of the re-dispersed nanosuspension were– 47 mV and 7.0, respectively. The high zeta potential value indicates the strong stabilizing effect of electrostatic repulsion, and under neutral conditions, the pesticide did not decompose easily.


Evaluation of Stability and Biological Activity of Solid Nanodispersion of Lambda-Cyhalothrin.

Cui B, Feng L, Pan Z, Yu M, Zeng Z, Sun C, Zhao X, Wang Y, Cui H - PLoS ONE (2015)

SEM photograph of lambda-cyhalothrin nanoparticles.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4539193&req=5

pone.0135953.g005: SEM photograph of lambda-cyhalothrin nanoparticles.
Mentions: As an example, the solid nanodispersion containing 8% (w/w) lambda-cyhalothrin with 0.4% (w/w) surfactant was subjected to a detailed characterization. The mean size and D90 of the re-dispersed aqueous solution of the formulation measured by DLS were 21.7±0.1 nm and 82.8±0.9 nm, respectively. According to the SEM image, the nanoparticles were spherical, and the particle size was in the range of 25 nm to 85 nm (Fig 5), agreeing well with the DLS results. The particles of the solid nanodispersion are significantly smaller than the particles obtained by the solidification of microemulsions and nanosuspensions prepared by high pressure homogenization [20,26,33–35]. This result proves that melt-emulsification combined with high-speed shearing is an effective method for constructing pesticide nano-formulations. A suspension with an absolute zeta potential value higher than 30 mV is always considered stable [36]. However, good stability of a suspension with lower zeta potential can also be obtained when the surfactant provides steric stabilization in addition to electrostatic repulsion [20,37,38]. In this study, the zeta potential and pH of the re-dispersed nanosuspension were– 47 mV and 7.0, respectively. The high zeta potential value indicates the strong stabilizing effect of electrostatic repulsion, and under neutral conditions, the pesticide did not decompose easily.

Bottom Line: In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods.The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability.The formulation is free of organic solvents, and the use of surfactant is reduced.

View Article: PubMed Central - PubMed

Affiliation: Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.

ABSTRACT
Pesticides are essential agrochemicals used to protect plants from diseases, pests and weeds. However, the formulation defects of conventional pesticides cause food toxicity and ecological environmental problems. In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods. The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability. The formulation is free of organic solvents, and the use of surfactant is reduced. Therefore, the application of the solid nanodispersion in crop production will improve efficacy and reduce the occurrence of both pesticide residues in food and environmental pollution from pesticides.

No MeSH data available.


Related in: MedlinePlus