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Evaluation of Stability and Biological Activity of Solid Nanodispersion of Lambda-Cyhalothrin.

Cui B, Feng L, Pan Z, Yu M, Zeng Z, Sun C, Zhao X, Wang Y, Cui H - PLoS ONE (2015)

Bottom Line: In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods.The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability.The formulation is free of organic solvents, and the use of surfactant is reduced.

View Article: PubMed Central - PubMed

Affiliation: Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.

ABSTRACT
Pesticides are essential agrochemicals used to protect plants from diseases, pests and weeds. However, the formulation defects of conventional pesticides cause food toxicity and ecological environmental problems. In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods. The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability. The formulation is free of organic solvents, and the use of surfactant is reduced. Therefore, the application of the solid nanodispersion in crop production will improve efficacy and reduce the occurrence of both pesticide residues in food and environmental pollution from pesticides.

No MeSH data available.


Related in: MedlinePlus

Particle properties of four lambda-cyhalothrin solid nanodispersions with different pesticide contents.D90: particle size expressed by the 90% diameter percentile; PDI: polydispersity index.
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pone.0135953.g004: Particle properties of four lambda-cyhalothrin solid nanodispersions with different pesticide contents.D90: particle size expressed by the 90% diameter percentile; PDI: polydispersity index.

Mentions: To improve the physical stability of the formulation and prolong its shelf life, the nanosuspensions were transformed into solid nanodispersions by lyophilization. Lyophilization has been widely used to produce drug powders from solutions in the pharmaceutical field, and it has proven to be more conducive to preventing particle aggregation than spray-drying method [14,26]. Sucrose is a commonly used carrier and can also be used as an antifreeze agent to protect suspensions from freezing and desiccation impairment [11]. In this study, sucrose as a water-soluble carrier exhibited excellent performance in terms of maintaining the particle size and distribution of the product. As shown in Fig 4, all four solid nanodispersions with different pesticide contents studied were characterized by a mean size and D90 of less than 32 nm and 110 nm, respectively. This clarified that combining the melt-emulsification plus high-speed shearing with freeze-drying is an efficient way to construct a uniform solid nanodispersion, and the pesticide loading in the solid formulation could easily be adjusted by the amount of carrier added.


Evaluation of Stability and Biological Activity of Solid Nanodispersion of Lambda-Cyhalothrin.

Cui B, Feng L, Pan Z, Yu M, Zeng Z, Sun C, Zhao X, Wang Y, Cui H - PLoS ONE (2015)

Particle properties of four lambda-cyhalothrin solid nanodispersions with different pesticide contents.D90: particle size expressed by the 90% diameter percentile; PDI: polydispersity index.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4539193&req=5

pone.0135953.g004: Particle properties of four lambda-cyhalothrin solid nanodispersions with different pesticide contents.D90: particle size expressed by the 90% diameter percentile; PDI: polydispersity index.
Mentions: To improve the physical stability of the formulation and prolong its shelf life, the nanosuspensions were transformed into solid nanodispersions by lyophilization. Lyophilization has been widely used to produce drug powders from solutions in the pharmaceutical field, and it has proven to be more conducive to preventing particle aggregation than spray-drying method [14,26]. Sucrose is a commonly used carrier and can also be used as an antifreeze agent to protect suspensions from freezing and desiccation impairment [11]. In this study, sucrose as a water-soluble carrier exhibited excellent performance in terms of maintaining the particle size and distribution of the product. As shown in Fig 4, all four solid nanodispersions with different pesticide contents studied were characterized by a mean size and D90 of less than 32 nm and 110 nm, respectively. This clarified that combining the melt-emulsification plus high-speed shearing with freeze-drying is an efficient way to construct a uniform solid nanodispersion, and the pesticide loading in the solid formulation could easily be adjusted by the amount of carrier added.

Bottom Line: In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods.The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability.The formulation is free of organic solvents, and the use of surfactant is reduced.

View Article: PubMed Central - PubMed

Affiliation: Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.

ABSTRACT
Pesticides are essential agrochemicals used to protect plants from diseases, pests and weeds. However, the formulation defects of conventional pesticides cause food toxicity and ecological environmental problems. In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods. The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability. The formulation is free of organic solvents, and the use of surfactant is reduced. Therefore, the application of the solid nanodispersion in crop production will improve efficacy and reduce the occurrence of both pesticide residues in food and environmental pollution from pesticides.

No MeSH data available.


Related in: MedlinePlus