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Evaluation of Stability and Biological Activity of Solid Nanodispersion of Lambda-Cyhalothrin.

Cui B, Feng L, Pan Z, Yu M, Zeng Z, Sun C, Zhao X, Wang Y, Cui H - PLoS ONE (2015)

Bottom Line: In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods.The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability.The formulation is free of organic solvents, and the use of surfactant is reduced.

View Article: PubMed Central - PubMed

Affiliation: Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.

ABSTRACT
Pesticides are essential agrochemicals used to protect plants from diseases, pests and weeds. However, the formulation defects of conventional pesticides cause food toxicity and ecological environmental problems. In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods. The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability. The formulation is free of organic solvents, and the use of surfactant is reduced. Therefore, the application of the solid nanodispersion in crop production will improve efficacy and reduce the occurrence of both pesticide residues in food and environmental pollution from pesticides.

No MeSH data available.


Related in: MedlinePlus

Particle properties of 5% (w/w) lambda-cyhalothrin nanosuspensions prepared at different temperatures.D90: particle size expressed by the 90% diameter percentile; PDI: polydispersity index.
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pone.0135953.g003: Particle properties of 5% (w/w) lambda-cyhalothrin nanosuspensions prepared at different temperatures.D90: particle size expressed by the 90% diameter percentile; PDI: polydispersity index.

Mentions: Fig 3 shows the influence of temperature on the produced nanoparticles. The results reveal that the particle size decreased as the temperature increased. The mean size of the pesticide particles declined significantly to 28.7 nm above the melting point of lambda-cyhalothrin (49.2°C). According to previous reports, a melting process, such as melt agglomeration, can improve the dispersion uniformity of a drug in solid dispersion and enhance its dissolution rate [31,32]. In this investigation, the particle size reduction resulting from raising the temperature above 49.2°C was due to the melting of the pesticide, which then gathered into oily droplets that were subsequently diminished into smaller droplets by high shearing forces. These smaller droplets were easily encapsulated and dispersed by the surfactants. In addition, the particle size of the nanosuspension changed little above 80°C. This result further confirms that temperature affected the particle size of the nanosuspensions by changing the pesticide’s physical properties. Ultimately, 80°C was chosen for the preparation of lambda-cyhalothrin nanoparticles.


Evaluation of Stability and Biological Activity of Solid Nanodispersion of Lambda-Cyhalothrin.

Cui B, Feng L, Pan Z, Yu M, Zeng Z, Sun C, Zhao X, Wang Y, Cui H - PLoS ONE (2015)

Particle properties of 5% (w/w) lambda-cyhalothrin nanosuspensions prepared at different temperatures.D90: particle size expressed by the 90% diameter percentile; PDI: polydispersity index.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4539193&req=5

pone.0135953.g003: Particle properties of 5% (w/w) lambda-cyhalothrin nanosuspensions prepared at different temperatures.D90: particle size expressed by the 90% diameter percentile; PDI: polydispersity index.
Mentions: Fig 3 shows the influence of temperature on the produced nanoparticles. The results reveal that the particle size decreased as the temperature increased. The mean size of the pesticide particles declined significantly to 28.7 nm above the melting point of lambda-cyhalothrin (49.2°C). According to previous reports, a melting process, such as melt agglomeration, can improve the dispersion uniformity of a drug in solid dispersion and enhance its dissolution rate [31,32]. In this investigation, the particle size reduction resulting from raising the temperature above 49.2°C was due to the melting of the pesticide, which then gathered into oily droplets that were subsequently diminished into smaller droplets by high shearing forces. These smaller droplets were easily encapsulated and dispersed by the surfactants. In addition, the particle size of the nanosuspension changed little above 80°C. This result further confirms that temperature affected the particle size of the nanosuspensions by changing the pesticide’s physical properties. Ultimately, 80°C was chosen for the preparation of lambda-cyhalothrin nanoparticles.

Bottom Line: In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods.The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability.The formulation is free of organic solvents, and the use of surfactant is reduced.

View Article: PubMed Central - PubMed

Affiliation: Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.

ABSTRACT
Pesticides are essential agrochemicals used to protect plants from diseases, pests and weeds. However, the formulation defects of conventional pesticides cause food toxicity and ecological environmental problems. In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods. The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability. The formulation is free of organic solvents, and the use of surfactant is reduced. Therefore, the application of the solid nanodispersion in crop production will improve efficacy and reduce the occurrence of both pesticide residues in food and environmental pollution from pesticides.

No MeSH data available.


Related in: MedlinePlus