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Evaluation of Stability and Biological Activity of Solid Nanodispersion of Lambda-Cyhalothrin.

Cui B, Feng L, Pan Z, Yu M, Zeng Z, Sun C, Zhao X, Wang Y, Cui H - PLoS ONE (2015)

Bottom Line: In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods.The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability.The formulation is free of organic solvents, and the use of surfactant is reduced.

View Article: PubMed Central - PubMed

Affiliation: Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.

ABSTRACT
Pesticides are essential agrochemicals used to protect plants from diseases, pests and weeds. However, the formulation defects of conventional pesticides cause food toxicity and ecological environmental problems. In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods. The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability. The formulation is free of organic solvents, and the use of surfactant is reduced. Therefore, the application of the solid nanodispersion in crop production will improve efficacy and reduce the occurrence of both pesticide residues in food and environmental pollution from pesticides.

No MeSH data available.


Related in: MedlinePlus

Effect of the shearing process on the particle properties of 5% (w/w) lambda-cyhalothrin nanosuspensions.D90: particle size expressed by the 90% diameter percentile; PDI: polydispersity index; rpm: revolutions per minute.
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pone.0135953.g002: Effect of the shearing process on the particle properties of 5% (w/w) lambda-cyhalothrin nanosuspensions.D90: particle size expressed by the 90% diameter percentile; PDI: polydispersity index; rpm: revolutions per minute.

Mentions: In this experiment, the process parameters of the melt-emulsification and high-speed shearing methods were investigated, including the shearing speed, shearing time and melting temperature. Fig 2 reveals the effects of shearing speed and time on the particle size and dispersibility of the nanosuspensions. Obviously, the mean size, D90 and PDI of the nanoparticles produced at 6000 rpm were biggest (Fig 2a). This result shows that the production of a nanosuspension with a narrow size distribution requires sufficient energy input, but the conditions remain milder than high pressure homogenization. As shown in Fig 2a, for speeds at or above 10000 rpm, there was no significant difference in mean particle size (approximately 17 nm); nevertheless, the PDI of the 10000-rpm shearing system was smaller than that of the solutions produced at 13000 and 16000 rpm. Therefore, the shearing speed of 10000 rpm was considered to be an appropriate condition for preparing lambda-cyhalothrin nanoparticles. Fig 2b shows that the mean size and D90 of the nanoparticles decreased as the shearing time prolonged at a constant shearing speed of 10000 rpm. After the shearing time exceeding 10 min, the particle size changed little. Therefore, considering the nanosizing effect and energy efficiency, the shearing time of 10 min was chosen.


Evaluation of Stability and Biological Activity of Solid Nanodispersion of Lambda-Cyhalothrin.

Cui B, Feng L, Pan Z, Yu M, Zeng Z, Sun C, Zhao X, Wang Y, Cui H - PLoS ONE (2015)

Effect of the shearing process on the particle properties of 5% (w/w) lambda-cyhalothrin nanosuspensions.D90: particle size expressed by the 90% diameter percentile; PDI: polydispersity index; rpm: revolutions per minute.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4539193&req=5

pone.0135953.g002: Effect of the shearing process on the particle properties of 5% (w/w) lambda-cyhalothrin nanosuspensions.D90: particle size expressed by the 90% diameter percentile; PDI: polydispersity index; rpm: revolutions per minute.
Mentions: In this experiment, the process parameters of the melt-emulsification and high-speed shearing methods were investigated, including the shearing speed, shearing time and melting temperature. Fig 2 reveals the effects of shearing speed and time on the particle size and dispersibility of the nanosuspensions. Obviously, the mean size, D90 and PDI of the nanoparticles produced at 6000 rpm were biggest (Fig 2a). This result shows that the production of a nanosuspension with a narrow size distribution requires sufficient energy input, but the conditions remain milder than high pressure homogenization. As shown in Fig 2a, for speeds at or above 10000 rpm, there was no significant difference in mean particle size (approximately 17 nm); nevertheless, the PDI of the 10000-rpm shearing system was smaller than that of the solutions produced at 13000 and 16000 rpm. Therefore, the shearing speed of 10000 rpm was considered to be an appropriate condition for preparing lambda-cyhalothrin nanoparticles. Fig 2b shows that the mean size and D90 of the nanoparticles decreased as the shearing time prolonged at a constant shearing speed of 10000 rpm. After the shearing time exceeding 10 min, the particle size changed little. Therefore, considering the nanosizing effect and energy efficiency, the shearing time of 10 min was chosen.

Bottom Line: In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods.The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability.The formulation is free of organic solvents, and the use of surfactant is reduced.

View Article: PubMed Central - PubMed

Affiliation: Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.

ABSTRACT
Pesticides are essential agrochemicals used to protect plants from diseases, pests and weeds. However, the formulation defects of conventional pesticides cause food toxicity and ecological environmental problems. In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods. The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability. The formulation is free of organic solvents, and the use of surfactant is reduced. Therefore, the application of the solid nanodispersion in crop production will improve efficacy and reduce the occurrence of both pesticide residues in food and environmental pollution from pesticides.

No MeSH data available.


Related in: MedlinePlus