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Evaluation of Stability and Biological Activity of Solid Nanodispersion of Lambda-Cyhalothrin.

Cui B, Feng L, Pan Z, Yu M, Zeng Z, Sun C, Zhao X, Wang Y, Cui H - PLoS ONE (2015)

Bottom Line: In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods.The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability.The formulation is free of organic solvents, and the use of surfactant is reduced.

View Article: PubMed Central - PubMed

Affiliation: Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.

ABSTRACT
Pesticides are essential agrochemicals used to protect plants from diseases, pests and weeds. However, the formulation defects of conventional pesticides cause food toxicity and ecological environmental problems. In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods. The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability. The formulation is free of organic solvents, and the use of surfactant is reduced. Therefore, the application of the solid nanodispersion in crop production will improve efficacy and reduce the occurrence of both pesticide residues in food and environmental pollution from pesticides.

No MeSH data available.


Related in: MedlinePlus

Particle properties of nanosuspensions containing 5% (w/w) lambda-cyhalothrin with different surfactant-to-pesticide ratios.D90: particle size expressed by the 90% diameter percentile; PDI: polydispersity index.
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pone.0135953.g001: Particle properties of nanosuspensions containing 5% (w/w) lambda-cyhalothrin with different surfactant-to-pesticide ratios.D90: particle size expressed by the 90% diameter percentile; PDI: polydispersity index.

Mentions: Fig 1 shows the effect of the surfactant-to-pesticide ratio on the particle size and distribution of the nanosuspensions. As the ratio increased from 1:50 to 1:20, the mean size and D90 of the pesticide nanoparticles decreased. However, the mean particle size continuously increased as the surfactant ratio increased from 1:20 to 1:3. This result demonstrates that pesticide nanoparticles exhibited the smallest size and narrow distribution at the 1:20 ratio of surfactant to lambda-cyhalothrin. As the surfactant proportion increases, the neighbouring nanoparticles may aggregate owing to the entanglement of long alkyl chains of polymeric MRES by intermolecular interactions [26,27]. The optimized surfactant content in the nanodispersion was much lower than that in most microemulsion and solid microemulsion formulations [28–30].


Evaluation of Stability and Biological Activity of Solid Nanodispersion of Lambda-Cyhalothrin.

Cui B, Feng L, Pan Z, Yu M, Zeng Z, Sun C, Zhao X, Wang Y, Cui H - PLoS ONE (2015)

Particle properties of nanosuspensions containing 5% (w/w) lambda-cyhalothrin with different surfactant-to-pesticide ratios.D90: particle size expressed by the 90% diameter percentile; PDI: polydispersity index.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4539193&req=5

pone.0135953.g001: Particle properties of nanosuspensions containing 5% (w/w) lambda-cyhalothrin with different surfactant-to-pesticide ratios.D90: particle size expressed by the 90% diameter percentile; PDI: polydispersity index.
Mentions: Fig 1 shows the effect of the surfactant-to-pesticide ratio on the particle size and distribution of the nanosuspensions. As the ratio increased from 1:50 to 1:20, the mean size and D90 of the pesticide nanoparticles decreased. However, the mean particle size continuously increased as the surfactant ratio increased from 1:20 to 1:3. This result demonstrates that pesticide nanoparticles exhibited the smallest size and narrow distribution at the 1:20 ratio of surfactant to lambda-cyhalothrin. As the surfactant proportion increases, the neighbouring nanoparticles may aggregate owing to the entanglement of long alkyl chains of polymeric MRES by intermolecular interactions [26,27]. The optimized surfactant content in the nanodispersion was much lower than that in most microemulsion and solid microemulsion formulations [28–30].

Bottom Line: In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods.The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability.The formulation is free of organic solvents, and the use of surfactant is reduced.

View Article: PubMed Central - PubMed

Affiliation: Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.

ABSTRACT
Pesticides are essential agrochemicals used to protect plants from diseases, pests and weeds. However, the formulation defects of conventional pesticides cause food toxicity and ecological environmental problems. In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods. The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability. The formulation is free of organic solvents, and the use of surfactant is reduced. Therefore, the application of the solid nanodispersion in crop production will improve efficacy and reduce the occurrence of both pesticide residues in food and environmental pollution from pesticides.

No MeSH data available.


Related in: MedlinePlus