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The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease.

Marton N, Baricza E, Érsek B, Buzás EI, Nagy G - Mediators Inflamm. (2015)

Bottom Line: Although Src-like adaptor proteins (SLAP-1 and SLAP-2) were mainly studied in lymphocytes, where they act as negative regulators and provide fine control of receptor signaling, recently, several other functions of these proteins were discovered.Both adaptor proteins are expressed in a wide variety of tissues, where they have mostly inhibitory effects on multiple intracellular signaling pathways.In this review, we summarize the diverse effects of SLAP proteins.

View Article: PubMed Central - PubMed

Affiliation: Department of Genetics, Cell- and Immunobiology, Semmelweis University, 4 Nagyvárad Square, Budapest 1089, Hungary.

ABSTRACT
Although Src-like adaptor proteins (SLAP-1 and SLAP-2) were mainly studied in lymphocytes, where they act as negative regulators and provide fine control of receptor signaling, recently, several other functions of these proteins were discovered. In addition to the well-characterized immunoregulatory functions, SLAP proteins appear to have an essential role in the pathogenesis of type I hypersensitivity, osteoporosis, and numerous malignant diseases. Both adaptor proteins are expressed in a wide variety of tissues, where they have mostly inhibitory effects on multiple intracellular signaling pathways. In this review, we summarize the diverse effects of SLAP proteins.

No MeSH data available.


Related in: MedlinePlus

The role of SLAP-2 in monocytes/macrophages.
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fig5: The role of SLAP-2 in monocytes/macrophages.

Mentions: SLAP-2 is expressed in human monocytes and bone marrow cells [1, 35], but not in CSF1 independent monocyte cell lines such as RAW264.7 [5]. It was shown that SLAP-2 may bind to both c-Fms and c-Cbl, and several domains of SLAP-2 are involved in this interaction (Figure 5). The overexpression of SLAP-2 in murine bone marrow reduced the M-CSF-induced tyrosine phosphorylation [36]. SLAP-2 downregulates the c-Fms signaling through a c-Cbl dependent internalization and degradation of the CSF-1R, providing a negative feedback of the M-CSF pathway [37]. In addition, c-Fms stimulation induces the phosphorylation of the serine rich N-terminal domain of the SLAP-2 by a JNK dependent pathway [36].


The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease.

Marton N, Baricza E, Érsek B, Buzás EI, Nagy G - Mediators Inflamm. (2015)

The role of SLAP-2 in monocytes/macrophages.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4539169&req=5

fig5: The role of SLAP-2 in monocytes/macrophages.
Mentions: SLAP-2 is expressed in human monocytes and bone marrow cells [1, 35], but not in CSF1 independent monocyte cell lines such as RAW264.7 [5]. It was shown that SLAP-2 may bind to both c-Fms and c-Cbl, and several domains of SLAP-2 are involved in this interaction (Figure 5). The overexpression of SLAP-2 in murine bone marrow reduced the M-CSF-induced tyrosine phosphorylation [36]. SLAP-2 downregulates the c-Fms signaling through a c-Cbl dependent internalization and degradation of the CSF-1R, providing a negative feedback of the M-CSF pathway [37]. In addition, c-Fms stimulation induces the phosphorylation of the serine rich N-terminal domain of the SLAP-2 by a JNK dependent pathway [36].

Bottom Line: Although Src-like adaptor proteins (SLAP-1 and SLAP-2) were mainly studied in lymphocytes, where they act as negative regulators and provide fine control of receptor signaling, recently, several other functions of these proteins were discovered.Both adaptor proteins are expressed in a wide variety of tissues, where they have mostly inhibitory effects on multiple intracellular signaling pathways.In this review, we summarize the diverse effects of SLAP proteins.

View Article: PubMed Central - PubMed

Affiliation: Department of Genetics, Cell- and Immunobiology, Semmelweis University, 4 Nagyvárad Square, Budapest 1089, Hungary.

ABSTRACT
Although Src-like adaptor proteins (SLAP-1 and SLAP-2) were mainly studied in lymphocytes, where they act as negative regulators and provide fine control of receptor signaling, recently, several other functions of these proteins were discovered. In addition to the well-characterized immunoregulatory functions, SLAP proteins appear to have an essential role in the pathogenesis of type I hypersensitivity, osteoporosis, and numerous malignant diseases. Both adaptor proteins are expressed in a wide variety of tissues, where they have mostly inhibitory effects on multiple intracellular signaling pathways. In this review, we summarize the diverse effects of SLAP proteins.

No MeSH data available.


Related in: MedlinePlus