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The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease.

Marton N, Baricza E, Érsek B, Buzás EI, Nagy G - Mediators Inflamm. (2015)

Bottom Line: Although Src-like adaptor proteins (SLAP-1 and SLAP-2) were mainly studied in lymphocytes, where they act as negative regulators and provide fine control of receptor signaling, recently, several other functions of these proteins were discovered.Both adaptor proteins are expressed in a wide variety of tissues, where they have mostly inhibitory effects on multiple intracellular signaling pathways.In this review, we summarize the diverse effects of SLAP proteins.

View Article: PubMed Central - PubMed

Affiliation: Department of Genetics, Cell- and Immunobiology, Semmelweis University, 4 Nagyvárad Square, Budapest 1089, Hungary.

ABSTRACT
Although Src-like adaptor proteins (SLAP-1 and SLAP-2) were mainly studied in lymphocytes, where they act as negative regulators and provide fine control of receptor signaling, recently, several other functions of these proteins were discovered. In addition to the well-characterized immunoregulatory functions, SLAP proteins appear to have an essential role in the pathogenesis of type I hypersensitivity, osteoporosis, and numerous malignant diseases. Both adaptor proteins are expressed in a wide variety of tissues, where they have mostly inhibitory effects on multiple intracellular signaling pathways. In this review, we summarize the diverse effects of SLAP proteins.

No MeSH data available.


Related in: MedlinePlus

The role of SLAP in B lymphocytes.
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Related In: Results  -  Collection


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fig4: The role of SLAP in B lymphocytes.

Mentions: SLAP is associated with c-Cbl in B lymphocytes, leading to BCR recycling [33] (Figure 4). SLAP deficiency increases the BCR levels of immature B cells in HEL-specific MD4- transgenic mice, which is a frequently used model to study naïve B lymphocytes. In this model the upregulated receptor complex levels lead to increased signal transduction. SLAP deficient mice have an increased number of splenic B cells, but the surface expression of BCR and IgM of mature lymphocytes is decreased. Furthermore, the activation induced calcium flux is diminished in SLAP KO B cells. In virtue of the previous data SLAP regulates the level of BCR s which is essential for the adequate development and function of B cells [34].


The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease.

Marton N, Baricza E, Érsek B, Buzás EI, Nagy G - Mediators Inflamm. (2015)

The role of SLAP in B lymphocytes.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4539169&req=5

fig4: The role of SLAP in B lymphocytes.
Mentions: SLAP is associated with c-Cbl in B lymphocytes, leading to BCR recycling [33] (Figure 4). SLAP deficiency increases the BCR levels of immature B cells in HEL-specific MD4- transgenic mice, which is a frequently used model to study naïve B lymphocytes. In this model the upregulated receptor complex levels lead to increased signal transduction. SLAP deficient mice have an increased number of splenic B cells, but the surface expression of BCR and IgM of mature lymphocytes is decreased. Furthermore, the activation induced calcium flux is diminished in SLAP KO B cells. In virtue of the previous data SLAP regulates the level of BCR s which is essential for the adequate development and function of B cells [34].

Bottom Line: Although Src-like adaptor proteins (SLAP-1 and SLAP-2) were mainly studied in lymphocytes, where they act as negative regulators and provide fine control of receptor signaling, recently, several other functions of these proteins were discovered.Both adaptor proteins are expressed in a wide variety of tissues, where they have mostly inhibitory effects on multiple intracellular signaling pathways.In this review, we summarize the diverse effects of SLAP proteins.

View Article: PubMed Central - PubMed

Affiliation: Department of Genetics, Cell- and Immunobiology, Semmelweis University, 4 Nagyvárad Square, Budapest 1089, Hungary.

ABSTRACT
Although Src-like adaptor proteins (SLAP-1 and SLAP-2) were mainly studied in lymphocytes, where they act as negative regulators and provide fine control of receptor signaling, recently, several other functions of these proteins were discovered. In addition to the well-characterized immunoregulatory functions, SLAP proteins appear to have an essential role in the pathogenesis of type I hypersensitivity, osteoporosis, and numerous malignant diseases. Both adaptor proteins are expressed in a wide variety of tissues, where they have mostly inhibitory effects on multiple intracellular signaling pathways. In this review, we summarize the diverse effects of SLAP proteins.

No MeSH data available.


Related in: MedlinePlus