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Progranulin Is Associated with Disease Activity in Patients with Rheumatoid Arthritis.

Cerezo LA, Kuklová M, Hulejová H, Vernerová Z, Kaspříková N, Veigl D, Pavelka K, Vencovský J, Šenolt L - Mediators Inflamm. (2015)

Bottom Line: Synovial fluid levels of PGRN were higher in patients with RA compared to OA (384.5 ± 275.3 versus 241.4 ± 165.2 ng/mL; P = 0.002).PGRN expression was significantly upregulated in the synovial tissue of RA patients particularly in the inflammatory infiltrates.PGRN levels were not associated with CRP or autoantibodies.

View Article: PubMed Central - PubMed

Affiliation: Institute of Rheumatology, Na Slupi 4, 12850 Prague 2, Czech Republic.

ABSTRACT

Objective: Progranulin (PGRN) is implicated in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to assess the relationship between PGRN and disease activity in RA.

Methods: PGRN levels were evaluated in patients with RA (n = 47) and OA (n = 42) and healthy controls (n = 41). Immunohistochemical analysis of PGRN in synovial tissues was performed. The association between PGRN and C-reactive protein (CRP), disease activity score (DAS28-CRP), and health assessment questionnaire (HAQ) was studied.

Results: Circulating PGRN was elevated in patients with RA and OA compared to healthy controls (227.1 ± 100.2 and 221.5 ± 102.5 versus 128.1 ± 34.7 ng/mL; P < 0.001). Synovial fluid levels of PGRN were higher in patients with RA compared to OA (384.5 ± 275.3 versus 241.4 ± 165.2 ng/mL; P = 0.002). PGRN expression was significantly upregulated in the synovial tissue of RA patients particularly in the inflammatory infiltrates. Serum PGRN levels correlated with DAS28 (r = 0.327, P = 0.049) and HAQ score (r = 0.323, P = 0.032), while synovial fluid PGRN correlated only with HAQ (r = 0.310, P = 0.043) in patients with RA. PGRN levels were not associated with CRP or autoantibodies.

Conclusions: This study demonstrates increased PGRN expression at local sites of inflammation and association between PGRN levels, disease activity, and functional impairment in patients with RA.

No MeSH data available.


Related in: MedlinePlus

Progranulin (PGRN) levels in the synovial fluid, but not in the serum, were significantly higher in rheumatoid arthritis (RA) compared with osteoarthritis (OA) patients. Serum PGRN was significantly elevated in RA and OA patients compared to healthy controls (HC). The concentration of PGRN in patients with RA was significantly higher in synovial fluid compared to serum. Data are expressed as mean. ∗P < 0.01, ∗∗P < 0.001.
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fig2: Progranulin (PGRN) levels in the synovial fluid, but not in the serum, were significantly higher in rheumatoid arthritis (RA) compared with osteoarthritis (OA) patients. Serum PGRN was significantly elevated in RA and OA patients compared to healthy controls (HC). The concentration of PGRN in patients with RA was significantly higher in synovial fluid compared to serum. Data are expressed as mean. ∗P < 0.01, ∗∗P < 0.001.

Mentions: The synovial fluid PGRN levels were significantly higher in RA than in OA patients (384.5 ± 275.3 versus 241.4 ± 165.2 ng/mL; P = 0.002) (Figure 2). However, circulating PGRN levels did not differ between RA and OA patients, but both were higher compared to those in healthy individuals (227.1 ± 100.2 and 221.5 ± 102.5 versus 128.1 ± 34.7 ng/mL; P < 0.001) (Figure 2). The levels of PGRN were significantly elevated in synovial fluid compared to serum in RA patients (P < 0.001). In addition, PGRN levels in the serum and in the synovial fluid strongly correlated in RA patients (r = 0.551, P < 0.0001). There was no correlation between the serum and synovial fluid PGRN observed in OA patients (r = 0.205, P = 0.199). The levels of PGRN were not affected by sex, age, or treatment.


Progranulin Is Associated with Disease Activity in Patients with Rheumatoid Arthritis.

Cerezo LA, Kuklová M, Hulejová H, Vernerová Z, Kaspříková N, Veigl D, Pavelka K, Vencovský J, Šenolt L - Mediators Inflamm. (2015)

Progranulin (PGRN) levels in the synovial fluid, but not in the serum, were significantly higher in rheumatoid arthritis (RA) compared with osteoarthritis (OA) patients. Serum PGRN was significantly elevated in RA and OA patients compared to healthy controls (HC). The concentration of PGRN in patients with RA was significantly higher in synovial fluid compared to serum. Data are expressed as mean. ∗P < 0.01, ∗∗P < 0.001.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4539115&req=5

fig2: Progranulin (PGRN) levels in the synovial fluid, but not in the serum, were significantly higher in rheumatoid arthritis (RA) compared with osteoarthritis (OA) patients. Serum PGRN was significantly elevated in RA and OA patients compared to healthy controls (HC). The concentration of PGRN in patients with RA was significantly higher in synovial fluid compared to serum. Data are expressed as mean. ∗P < 0.01, ∗∗P < 0.001.
Mentions: The synovial fluid PGRN levels were significantly higher in RA than in OA patients (384.5 ± 275.3 versus 241.4 ± 165.2 ng/mL; P = 0.002) (Figure 2). However, circulating PGRN levels did not differ between RA and OA patients, but both were higher compared to those in healthy individuals (227.1 ± 100.2 and 221.5 ± 102.5 versus 128.1 ± 34.7 ng/mL; P < 0.001) (Figure 2). The levels of PGRN were significantly elevated in synovial fluid compared to serum in RA patients (P < 0.001). In addition, PGRN levels in the serum and in the synovial fluid strongly correlated in RA patients (r = 0.551, P < 0.0001). There was no correlation between the serum and synovial fluid PGRN observed in OA patients (r = 0.205, P = 0.199). The levels of PGRN were not affected by sex, age, or treatment.

Bottom Line: Synovial fluid levels of PGRN were higher in patients with RA compared to OA (384.5 ± 275.3 versus 241.4 ± 165.2 ng/mL; P = 0.002).PGRN expression was significantly upregulated in the synovial tissue of RA patients particularly in the inflammatory infiltrates.PGRN levels were not associated with CRP or autoantibodies.

View Article: PubMed Central - PubMed

Affiliation: Institute of Rheumatology, Na Slupi 4, 12850 Prague 2, Czech Republic.

ABSTRACT

Objective: Progranulin (PGRN) is implicated in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to assess the relationship between PGRN and disease activity in RA.

Methods: PGRN levels were evaluated in patients with RA (n = 47) and OA (n = 42) and healthy controls (n = 41). Immunohistochemical analysis of PGRN in synovial tissues was performed. The association between PGRN and C-reactive protein (CRP), disease activity score (DAS28-CRP), and health assessment questionnaire (HAQ) was studied.

Results: Circulating PGRN was elevated in patients with RA and OA compared to healthy controls (227.1 ± 100.2 and 221.5 ± 102.5 versus 128.1 ± 34.7 ng/mL; P < 0.001). Synovial fluid levels of PGRN were higher in patients with RA compared to OA (384.5 ± 275.3 versus 241.4 ± 165.2 ng/mL; P = 0.002). PGRN expression was significantly upregulated in the synovial tissue of RA patients particularly in the inflammatory infiltrates. Serum PGRN levels correlated with DAS28 (r = 0.327, P = 0.049) and HAQ score (r = 0.323, P = 0.032), while synovial fluid PGRN correlated only with HAQ (r = 0.310, P = 0.043) in patients with RA. PGRN levels were not associated with CRP or autoantibodies.

Conclusions: This study demonstrates increased PGRN expression at local sites of inflammation and association between PGRN levels, disease activity, and functional impairment in patients with RA.

No MeSH data available.


Related in: MedlinePlus