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Inflammatory Mediators of Leprosy Reactional Episodes and Dental Infections: A Systematic Review.

Cortela DC, de Souza Junior AL, Virmond MC, Ignotti E - Mediators Inflamm. (2015)

Bottom Line: Serum IL-6 and TNF-α concentrations were significant during periodontal and reactional lesion evolution; IFN-γ and IL-1β were associated with types 1 and 2 reactions and chronic periodontal disease.IFN-γ and IL-1β were significant for leprosy reactions and periodontal diseases.This pattern was maintained in serum.

View Article: PubMed Central - PubMed

Affiliation: School of Health Sciences, State University of Mato Grosso, São João Street, S/N, 78000-000 Cáceres, MT, Brazil.

ABSTRACT
Reactional episodes in leprosy are a result of complex interactions between the immune system, Mycobacterium leprae, and predisposing factors, including dental infections. To determine the main inflammatory mediators in the immunopathological process of dental infections and leprosy reactions, we conducted a systematic review of primary literature published between 1996 and 2013. A three-stage literature search was performed (Stage I, "leprosy reactions" and "inflammatory mediators"; Stage II, "dental infections" and "inflammatory mediators"; and Stage III, "leprosy reactions," "dental infections," and "inflammatory mediators"). Of the 911 eligible publications, 10 were selected in Stage I, 68 in Stage II, and 1 in Stage III. Of the 27 studied inflammatory mediators, the main proinflammatory mediators were IL-6, IFN-γ, TNF-α, IL-1β, and IL-17; the main anti-inflammatory mediators were IL-10 and IL-4. Serum IL-6 and TNF-α concentrations were significant during periodontal and reactional lesion evolution; IFN-γ and IL-1β were associated with types 1 and 2 reactions and chronic periodontal disease. The proinflammatory mediators in dental infections and leprosy reactions, especially IL-6 and TNF-α, were similar across studies, regardless of the laboratory technique and sample type. IFN-γ and IL-1β were significant for leprosy reactions and periodontal diseases. This pattern was maintained in serum.

No MeSH data available.


Related in: MedlinePlus

Flowchart of the selection of scientific articles published between January 1, 1996, and December 31, 2013, regarding inflammatory mediators involved in leprosy reactional episodes and dental infections. Stage I (bibliographic search for inflammatory mediators/leprosy reactions); Stage II (bibliographic search for inflammatory mediators/dental infections); Stage III (bibliographic search for inflammatory mediators/dental infections/leprosy reactions).
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fig1: Flowchart of the selection of scientific articles published between January 1, 1996, and December 31, 2013, regarding inflammatory mediators involved in leprosy reactional episodes and dental infections. Stage I (bibliographic search for inflammatory mediators/leprosy reactions); Stage II (bibliographic search for inflammatory mediators/dental infections); Stage III (bibliographic search for inflammatory mediators/dental infections/leprosy reactions).

Mentions: We identified 911 publications dated between January 1, 1996, and December 21, 2013, of which we excluded 795; a further 37 articles were duplicates. We selected the remaining 79 publications for analysis: 10 articles (12.7%) in Stage I, 68 articles (86.0%) in Stage II, and 1 article (1.3%) in Stage III. In these articles of dental infections and the occurrence of reactional episodes, the 27 researched inflammatory mediators, independent of the laboratory technique and type of sample, were TNF-α, IFN-γ, IL-1/IL-1β, IL-1α, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-12p35, IL-12p70, IL-12p40, IL-15, IL-17, IL-17A, IL-17F, IL-18, IL-21, IL-23, IL-23 p19, and TGF-1β (Figure 1).


Inflammatory Mediators of Leprosy Reactional Episodes and Dental Infections: A Systematic Review.

Cortela DC, de Souza Junior AL, Virmond MC, Ignotti E - Mediators Inflamm. (2015)

Flowchart of the selection of scientific articles published between January 1, 1996, and December 31, 2013, regarding inflammatory mediators involved in leprosy reactional episodes and dental infections. Stage I (bibliographic search for inflammatory mediators/leprosy reactions); Stage II (bibliographic search for inflammatory mediators/dental infections); Stage III (bibliographic search for inflammatory mediators/dental infections/leprosy reactions).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4539113&req=5

fig1: Flowchart of the selection of scientific articles published between January 1, 1996, and December 31, 2013, regarding inflammatory mediators involved in leprosy reactional episodes and dental infections. Stage I (bibliographic search for inflammatory mediators/leprosy reactions); Stage II (bibliographic search for inflammatory mediators/dental infections); Stage III (bibliographic search for inflammatory mediators/dental infections/leprosy reactions).
Mentions: We identified 911 publications dated between January 1, 1996, and December 21, 2013, of which we excluded 795; a further 37 articles were duplicates. We selected the remaining 79 publications for analysis: 10 articles (12.7%) in Stage I, 68 articles (86.0%) in Stage II, and 1 article (1.3%) in Stage III. In these articles of dental infections and the occurrence of reactional episodes, the 27 researched inflammatory mediators, independent of the laboratory technique and type of sample, were TNF-α, IFN-γ, IL-1/IL-1β, IL-1α, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-12p35, IL-12p70, IL-12p40, IL-15, IL-17, IL-17A, IL-17F, IL-18, IL-21, IL-23, IL-23 p19, and TGF-1β (Figure 1).

Bottom Line: Serum IL-6 and TNF-α concentrations were significant during periodontal and reactional lesion evolution; IFN-γ and IL-1β were associated with types 1 and 2 reactions and chronic periodontal disease.IFN-γ and IL-1β were significant for leprosy reactions and periodontal diseases.This pattern was maintained in serum.

View Article: PubMed Central - PubMed

Affiliation: School of Health Sciences, State University of Mato Grosso, São João Street, S/N, 78000-000 Cáceres, MT, Brazil.

ABSTRACT
Reactional episodes in leprosy are a result of complex interactions between the immune system, Mycobacterium leprae, and predisposing factors, including dental infections. To determine the main inflammatory mediators in the immunopathological process of dental infections and leprosy reactions, we conducted a systematic review of primary literature published between 1996 and 2013. A three-stage literature search was performed (Stage I, "leprosy reactions" and "inflammatory mediators"; Stage II, "dental infections" and "inflammatory mediators"; and Stage III, "leprosy reactions," "dental infections," and "inflammatory mediators"). Of the 911 eligible publications, 10 were selected in Stage I, 68 in Stage II, and 1 in Stage III. Of the 27 studied inflammatory mediators, the main proinflammatory mediators were IL-6, IFN-γ, TNF-α, IL-1β, and IL-17; the main anti-inflammatory mediators were IL-10 and IL-4. Serum IL-6 and TNF-α concentrations were significant during periodontal and reactional lesion evolution; IFN-γ and IL-1β were associated with types 1 and 2 reactions and chronic periodontal disease. The proinflammatory mediators in dental infections and leprosy reactions, especially IL-6 and TNF-α, were similar across studies, regardless of the laboratory technique and sample type. IFN-γ and IL-1β were significant for leprosy reactions and periodontal diseases. This pattern was maintained in serum.

No MeSH data available.


Related in: MedlinePlus