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Mediators, Receptors, and Signalling Pathways in the Anti-Inflammatory and Antihyperalgesic Effects of Acupuncture.

McDonald JL, Cripps AW, Smith PK - Evid Based Complement Alternat Med (2015)

Bottom Line: A proposed model has previously hypothesized that acupuncture might downregulate proinflammatory neuropeptides, proinflammatory cytokines, and neurotrophins, modulating transient receptor potential vallinoid (TRPV1), a G-protein coupled receptor which plays a central role in allergic rhinitis.Recent research has been largely supportive of this model.Further research on the complex cross talk between receptors during inflammation is also helping to elucidate the mediators and signalling pathways activated by acupuncture.

View Article: PubMed Central - PubMed

Affiliation: School of Medicine, Griffith Health Institute, Griffith Health, Griffith University, Southport, QLD 4211, Australia.

ABSTRACT
Acupuncture has been used for millennia to treat allergic diseases including both intermittent rhinitis and persistent rhinitis. Besides the research on the efficacy and safety of acupuncture treatment for allergic rhinitis, research has also investigated how acupuncture might modulate immune function to exert anti-inflammatory effects. A proposed model has previously hypothesized that acupuncture might downregulate proinflammatory neuropeptides, proinflammatory cytokines, and neurotrophins, modulating transient receptor potential vallinoid (TRPV1), a G-protein coupled receptor which plays a central role in allergic rhinitis. Recent research has been largely supportive of this model. New advances in research include the discovery of a novel cholinergic anti-inflammatory pathway activated by acupuncture. A chemokine-mediated proliferation of opioid-containing macrophages in inflamed tissues, in response to acupuncture, has also been demonstrated for the first time. Further research on the complex cross talk between receptors during inflammation is also helping to elucidate the mediators and signalling pathways activated by acupuncture.

No MeSH data available.


Related in: MedlinePlus

Receptor interactions potentially involved in the anti-inflammatory effects of acupuncture.
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Related In: Results  -  Collection


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fig2: Receptor interactions potentially involved in the anti-inflammatory effects of acupuncture.

Mentions: Interactions between receptor types are now being reported with an increasing frequency. Acupuncture has been shown to influence the interactions between opioid receptors and chemokine receptors, as well as cannabinoid receptors (see Figure 2). Interactions between cannabinoid receptors and dopamine receptors have also been shown to be modulated by acupuncture [14].


Mediators, Receptors, and Signalling Pathways in the Anti-Inflammatory and Antihyperalgesic Effects of Acupuncture.

McDonald JL, Cripps AW, Smith PK - Evid Based Complement Alternat Med (2015)

Receptor interactions potentially involved in the anti-inflammatory effects of acupuncture.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4539069&req=5

fig2: Receptor interactions potentially involved in the anti-inflammatory effects of acupuncture.
Mentions: Interactions between receptor types are now being reported with an increasing frequency. Acupuncture has been shown to influence the interactions between opioid receptors and chemokine receptors, as well as cannabinoid receptors (see Figure 2). Interactions between cannabinoid receptors and dopamine receptors have also been shown to be modulated by acupuncture [14].

Bottom Line: A proposed model has previously hypothesized that acupuncture might downregulate proinflammatory neuropeptides, proinflammatory cytokines, and neurotrophins, modulating transient receptor potential vallinoid (TRPV1), a G-protein coupled receptor which plays a central role in allergic rhinitis.Recent research has been largely supportive of this model.Further research on the complex cross talk between receptors during inflammation is also helping to elucidate the mediators and signalling pathways activated by acupuncture.

View Article: PubMed Central - PubMed

Affiliation: School of Medicine, Griffith Health Institute, Griffith Health, Griffith University, Southport, QLD 4211, Australia.

ABSTRACT
Acupuncture has been used for millennia to treat allergic diseases including both intermittent rhinitis and persistent rhinitis. Besides the research on the efficacy and safety of acupuncture treatment for allergic rhinitis, research has also investigated how acupuncture might modulate immune function to exert anti-inflammatory effects. A proposed model has previously hypothesized that acupuncture might downregulate proinflammatory neuropeptides, proinflammatory cytokines, and neurotrophins, modulating transient receptor potential vallinoid (TRPV1), a G-protein coupled receptor which plays a central role in allergic rhinitis. Recent research has been largely supportive of this model. New advances in research include the discovery of a novel cholinergic anti-inflammatory pathway activated by acupuncture. A chemokine-mediated proliferation of opioid-containing macrophages in inflamed tissues, in response to acupuncture, has also been demonstrated for the first time. Further research on the complex cross talk between receptors during inflammation is also helping to elucidate the mediators and signalling pathways activated by acupuncture.

No MeSH data available.


Related in: MedlinePlus