Limits...
A Systematic Review of Rhubarb (a Traditional Chinese Medicine) Used for the Treatment of Experimental Sepsis.

Lai F, Zhang Y, Xie DP, Mai ST, Weng YN, Du JD, Wu GP, Zheng JX, Han Y - Evid Based Complement Alternat Med (2015)

Bottom Line: For thousands of years, Rhubarb had been used for various diseases including severe infection.It showed that Rhubarb might be effective in reducing injuries in gastrointestinal tract, lung, and liver induced by sepsis, and its potential mechanisms might include reducing oxidative stress and inflammation, ameliorating microcirculatory disturbance, and maintaining immune balance.Yet the positive findings should be interpreted with caution due to poor methodological quality.

View Article: PubMed Central - PubMed

Affiliation: Department of Intensive Care Unit, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510145, China.

ABSTRACT
Sepsis is a global major health problem in great need for more effective therapy. For thousands of years, Rhubarb had been used for various diseases including severe infection. Pharmacological studies and trials reported that Rhubarb may be effective in treating sepsis, but the efficacy and the quality of evidence remain unclear since there is no systematic review on Rhubarb for sepsis. The present study is the first systematic review of Rhubarb used for the treatment of experimental sepsis in both English and Chinese literatures by identifying 27 studies from 7 databases. It showed that Rhubarb might be effective in reducing injuries in gastrointestinal tract, lung, and liver induced by sepsis, and its potential mechanisms might include reducing oxidative stress and inflammation, ameliorating microcirculatory disturbance, and maintaining immune balance. Yet the positive findings should be interpreted with caution due to poor methodological quality. In a word, Rhubarb might be a promising candidate that is worth further clinical and experimental trials for sepsis therapy.

No MeSH data available.


Related in: MedlinePlus

Flow diagram.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4538976&req=5

fig1: Flow diagram.

Mentions: 2394 papers were retrieved from seven databases. 70 articles remained after screening by titles and abstracts, of which 31 records were removed for being duplicates. Another 3 articles were excluded for no full text was available with effort. By full-text reviewing, 12 studies were excluded according to the exclusion criteria. Three more eligible studies were included after handsearching of reference lists of the included articles and other relevant reviews. Finally, a total of 27 studies were included in qualitative synthesis [15–41]. The study selection process is summarized in a flow diagram (Figure 1).


A Systematic Review of Rhubarb (a Traditional Chinese Medicine) Used for the Treatment of Experimental Sepsis.

Lai F, Zhang Y, Xie DP, Mai ST, Weng YN, Du JD, Wu GP, Zheng JX, Han Y - Evid Based Complement Alternat Med (2015)

Flow diagram.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4538976&req=5

fig1: Flow diagram.
Mentions: 2394 papers were retrieved from seven databases. 70 articles remained after screening by titles and abstracts, of which 31 records were removed for being duplicates. Another 3 articles were excluded for no full text was available with effort. By full-text reviewing, 12 studies were excluded according to the exclusion criteria. Three more eligible studies were included after handsearching of reference lists of the included articles and other relevant reviews. Finally, a total of 27 studies were included in qualitative synthesis [15–41]. The study selection process is summarized in a flow diagram (Figure 1).

Bottom Line: For thousands of years, Rhubarb had been used for various diseases including severe infection.It showed that Rhubarb might be effective in reducing injuries in gastrointestinal tract, lung, and liver induced by sepsis, and its potential mechanisms might include reducing oxidative stress and inflammation, ameliorating microcirculatory disturbance, and maintaining immune balance.Yet the positive findings should be interpreted with caution due to poor methodological quality.

View Article: PubMed Central - PubMed

Affiliation: Department of Intensive Care Unit, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510145, China.

ABSTRACT
Sepsis is a global major health problem in great need for more effective therapy. For thousands of years, Rhubarb had been used for various diseases including severe infection. Pharmacological studies and trials reported that Rhubarb may be effective in treating sepsis, but the efficacy and the quality of evidence remain unclear since there is no systematic review on Rhubarb for sepsis. The present study is the first systematic review of Rhubarb used for the treatment of experimental sepsis in both English and Chinese literatures by identifying 27 studies from 7 databases. It showed that Rhubarb might be effective in reducing injuries in gastrointestinal tract, lung, and liver induced by sepsis, and its potential mechanisms might include reducing oxidative stress and inflammation, ameliorating microcirculatory disturbance, and maintaining immune balance. Yet the positive findings should be interpreted with caution due to poor methodological quality. In a word, Rhubarb might be a promising candidate that is worth further clinical and experimental trials for sepsis therapy.

No MeSH data available.


Related in: MedlinePlus