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Considerable Variation of Antibacterial Activity of Cu Nanoparticles Suspensions Depending on the Storage Time, Dispersive Medium, and Particle Sizes.

Zakharova OV, Godymchuk AY, Gusev AA, Gulchenko SI, Vasyukova IA, Kuznetsov DV - Biomed Res Int (2015)

Bottom Line: In this study we examined copper nanoparticles of various sizes obtained by the method of wire electric explosion: nanopowder average size 50 nm (Cu 50) and 100 nm (Cu 100).Ionic solution of Cu(2+) and sodium dichloroisocyanurate was used for comparison study.It has been observed that antibacterial properties of Cu 50 nanoparticle suspensions are ceased after 24-hour storage, while for Cu 100 suspensions no correlation between antibacterial properties and storage time has been noted.

View Article: PubMed Central - PubMed

Affiliation: Tambov State University named after G.R. Derzhavin, 33 Internatsionalnaya street, Tambov 392000, Russia.

ABSTRACT
Suspensions of Cu nanoparticles are promising for creating the new class of alternative antimicrobial products. In this study we examined copper nanoparticles of various sizes obtained by the method of wire electric explosion: nanopowder average size 50 nm (Cu 50) and 100 nm (Cu 100). The paper presents the complex study of the influence of physicochemical properties such as particle size and concentration of the freshly prepared and 24-hour suspensions of Cu nanoparticles in distilled water and physiological solution upon their toxicity to bacteria E. coli M-17. Ionic solution of Cu(2+) and sodium dichloroisocyanurate was used for comparison study. It has been shown that decrease in the nanoparticle size leads to changes in the correlation between toxicity and concentration as toxicity peaks are observed at low concentrations (0.0001⋯0.01 mg/L). It has been observed that antibacterial properties of Cu 50 nanoparticle suspensions are ceased after 24-hour storage, while for Cu 100 suspensions no correlation between antibacterial properties and storage time has been noted. Cu 100 nanoparticle suspensions at 10 mg/L concentration display higher toxicity at substituting physiological solution for water than Cu 50 suspensions. Dependence of the toxicity on the mean particle aggregates size in suspension was not revealed.

No MeSH data available.


Related in: MedlinePlus

Changes in the toxicity index for Cu 50 nanoparticle suspensions based on (a) water, Cu 50 + H2O, and (b) physiological solution, Cu 50 + PS.
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fig3: Changes in the toxicity index for Cu 50 nanoparticle suspensions based on (a) water, Cu 50 + H2O, and (b) physiological solution, Cu 50 + PS.

Mentions: The study of the antibacterial properties of 0.5-hour aqueous Cu 50 nanoparticle suspensions has allowed us to discover that toxicity observed at the lowest concentrations of 0.0001 mg/L decreases from 40 to 20 units with nanoparticle concentration growth up to 0.01 mg/L, no toxicity is observed in suspensions with 0.1…1 mg/L concentration, and the maximum value (≈50 units) is recorded at 10 mg/L suspension (Figure 3(a)). The solutions pH value monitoring throughout the testing process indicated slight deviation of pH up to 7.6 from the normal values of 6.8–7.4 specifically in suspensions with 0.0001 and 0.001 mg/L concentrations (Table 2). The highest value of toxicity index in 10 mg/L suspension may be connected with increased concentration of Cu2+ ions dispersed in the solution as a result of the sample dissolution during its hour-long exposure [35, 55].


Considerable Variation of Antibacterial Activity of Cu Nanoparticles Suspensions Depending on the Storage Time, Dispersive Medium, and Particle Sizes.

Zakharova OV, Godymchuk AY, Gusev AA, Gulchenko SI, Vasyukova IA, Kuznetsov DV - Biomed Res Int (2015)

Changes in the toxicity index for Cu 50 nanoparticle suspensions based on (a) water, Cu 50 + H2O, and (b) physiological solution, Cu 50 + PS.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4538334&req=5

fig3: Changes in the toxicity index for Cu 50 nanoparticle suspensions based on (a) water, Cu 50 + H2O, and (b) physiological solution, Cu 50 + PS.
Mentions: The study of the antibacterial properties of 0.5-hour aqueous Cu 50 nanoparticle suspensions has allowed us to discover that toxicity observed at the lowest concentrations of 0.0001 mg/L decreases from 40 to 20 units with nanoparticle concentration growth up to 0.01 mg/L, no toxicity is observed in suspensions with 0.1…1 mg/L concentration, and the maximum value (≈50 units) is recorded at 10 mg/L suspension (Figure 3(a)). The solutions pH value monitoring throughout the testing process indicated slight deviation of pH up to 7.6 from the normal values of 6.8–7.4 specifically in suspensions with 0.0001 and 0.001 mg/L concentrations (Table 2). The highest value of toxicity index in 10 mg/L suspension may be connected with increased concentration of Cu2+ ions dispersed in the solution as a result of the sample dissolution during its hour-long exposure [35, 55].

Bottom Line: In this study we examined copper nanoparticles of various sizes obtained by the method of wire electric explosion: nanopowder average size 50 nm (Cu 50) and 100 nm (Cu 100).Ionic solution of Cu(2+) and sodium dichloroisocyanurate was used for comparison study.It has been observed that antibacterial properties of Cu 50 nanoparticle suspensions are ceased after 24-hour storage, while for Cu 100 suspensions no correlation between antibacterial properties and storage time has been noted.

View Article: PubMed Central - PubMed

Affiliation: Tambov State University named after G.R. Derzhavin, 33 Internatsionalnaya street, Tambov 392000, Russia.

ABSTRACT
Suspensions of Cu nanoparticles are promising for creating the new class of alternative antimicrobial products. In this study we examined copper nanoparticles of various sizes obtained by the method of wire electric explosion: nanopowder average size 50 nm (Cu 50) and 100 nm (Cu 100). The paper presents the complex study of the influence of physicochemical properties such as particle size and concentration of the freshly prepared and 24-hour suspensions of Cu nanoparticles in distilled water and physiological solution upon their toxicity to bacteria E. coli M-17. Ionic solution of Cu(2+) and sodium dichloroisocyanurate was used for comparison study. It has been shown that decrease in the nanoparticle size leads to changes in the correlation between toxicity and concentration as toxicity peaks are observed at low concentrations (0.0001⋯0.01 mg/L). It has been observed that antibacterial properties of Cu 50 nanoparticle suspensions are ceased after 24-hour storage, while for Cu 100 suspensions no correlation between antibacterial properties and storage time has been noted. Cu 100 nanoparticle suspensions at 10 mg/L concentration display higher toxicity at substituting physiological solution for water than Cu 50 suspensions. Dependence of the toxicity on the mean particle aggregates size in suspension was not revealed.

No MeSH data available.


Related in: MedlinePlus