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Prognostic Value of MRS Metabolites in Postoperative Irradiated High Grade Gliomas.

Tolia M, Verganelakis D, Tsoukalas N, Kyrgias G, Papathanasiou M, Mosa E, Kokakis I, Kouvaris JR, Pissakas G, Pistevou-Gombaki K, Kelekis N, Kouloulias V - Biomed Res Int (2015)

Bottom Line: RFS was significantly worse in elderly patients (P = 0.001) along with the higher choline/creatine ratios at either baseline (P = 0.003) or six months post Radiotherapy (P = 0.042).Median RFS was 23 months in high choline/creatine levels ≥ 2 at 6 months after radiotherapy and 11 months for those with < 2 choline/creatine levels.There was a significant correlation of maximum difference of choline/creatine ratio with RFS (rho = 0.64, P = 0.045).

View Article: PubMed Central - PubMed

Affiliation: 2nd Department of Radiology, Radiation Oncology Unit, Medical School, Attikon University Hospital, 1 Rimini Street, Haidari, 12462 Athens, Greece.

ABSTRACT

Purpose: We studied the prognostic significance of Magnetic Resonance Spectroscopy (MRS) in operated high grade gliomas.

Materials and methods: Twelve patients were treated with radiotherapy and Temozolomide. The MRS data were taken four weeks after operation (before radiotherapy) and every six months after the completion of RT. The N-acetyl aspartate, choline, creatine, and myo-inositol parameters were quantified, analyzed, and correlated to recurrence-free survival (RFS).

Results: The median RFS was 26.06 months. RFS was significantly worse in elderly patients (P = 0.001) along with the higher choline/creatine ratios at either baseline (P = 0.003) or six months post Radiotherapy (P = 0.042). Median RFS was 23 months in high choline/creatine levels ≥ 2 at 6 months after radiotherapy and 11 months for those with < 2 choline/creatine levels. There was a significant correlation of maximum difference of choline/creatine ratio with RFS (rho = 0.64, P = 0.045).

Conclusion: Age and choline/creatine ratio are strong independent prognostic factors in high grade gliomas.

No MeSH data available.


Related in: MedlinePlus

Recurrence-free survival (RFS) correlated with max difference of Cho/Cr ratio with baseline (Spearman rho = 0.64, P = 0.045).
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fig3: Recurrence-free survival (RFS) correlated with max difference of Cho/Cr ratio with baseline (Spearman rho = 0.64, P = 0.045).

Mentions: All patients completed their irradiation schedule. At the most recent follow-up, five patients were alive and seven were dead. Median RFS was 26.06 months. The median overall survival time was thirty-two months. The patients' characteristics along with the RFS and MRS parameters are summarized in Table 1. In univariate analysis, age, NAA, Cho/Cr (baseline), and Cho/Cr at 6 months after RT were significant prognostic factors for RFS. When the above factors were entered into the multivariate model, the NNA lost its prognostic value, while only age and Cho/Cr ratios at baseline and 6 months thereafter had a significant impact top RFS. The other MRS parameters had no significant impact on RFS. The Cox-regression survival analysis for RFS between age and the MRS findings is shown in Table 2. As shown in Figures 1 and 2 median RFS was 23 months for patients with high Cho/Cr levels ≥2 (at baseline and 6 months after RT) and 11 months for those with <2 Cho/Cr levels (log-rank test: P = 0.0004 and P = 0.045, resp.). There was a significant correlation of maximum difference of Cho/Cr ratio with RFS (rho = 0.64, P = 0.045), as shown in Figure 3.


Prognostic Value of MRS Metabolites in Postoperative Irradiated High Grade Gliomas.

Tolia M, Verganelakis D, Tsoukalas N, Kyrgias G, Papathanasiou M, Mosa E, Kokakis I, Kouvaris JR, Pissakas G, Pistevou-Gombaki K, Kelekis N, Kouloulias V - Biomed Res Int (2015)

Recurrence-free survival (RFS) correlated with max difference of Cho/Cr ratio with baseline (Spearman rho = 0.64, P = 0.045).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4538329&req=5

fig3: Recurrence-free survival (RFS) correlated with max difference of Cho/Cr ratio with baseline (Spearman rho = 0.64, P = 0.045).
Mentions: All patients completed their irradiation schedule. At the most recent follow-up, five patients were alive and seven were dead. Median RFS was 26.06 months. The median overall survival time was thirty-two months. The patients' characteristics along with the RFS and MRS parameters are summarized in Table 1. In univariate analysis, age, NAA, Cho/Cr (baseline), and Cho/Cr at 6 months after RT were significant prognostic factors for RFS. When the above factors were entered into the multivariate model, the NNA lost its prognostic value, while only age and Cho/Cr ratios at baseline and 6 months thereafter had a significant impact top RFS. The other MRS parameters had no significant impact on RFS. The Cox-regression survival analysis for RFS between age and the MRS findings is shown in Table 2. As shown in Figures 1 and 2 median RFS was 23 months for patients with high Cho/Cr levels ≥2 (at baseline and 6 months after RT) and 11 months for those with <2 Cho/Cr levels (log-rank test: P = 0.0004 and P = 0.045, resp.). There was a significant correlation of maximum difference of Cho/Cr ratio with RFS (rho = 0.64, P = 0.045), as shown in Figure 3.

Bottom Line: RFS was significantly worse in elderly patients (P = 0.001) along with the higher choline/creatine ratios at either baseline (P = 0.003) or six months post Radiotherapy (P = 0.042).Median RFS was 23 months in high choline/creatine levels ≥ 2 at 6 months after radiotherapy and 11 months for those with < 2 choline/creatine levels.There was a significant correlation of maximum difference of choline/creatine ratio with RFS (rho = 0.64, P = 0.045).

View Article: PubMed Central - PubMed

Affiliation: 2nd Department of Radiology, Radiation Oncology Unit, Medical School, Attikon University Hospital, 1 Rimini Street, Haidari, 12462 Athens, Greece.

ABSTRACT

Purpose: We studied the prognostic significance of Magnetic Resonance Spectroscopy (MRS) in operated high grade gliomas.

Materials and methods: Twelve patients were treated with radiotherapy and Temozolomide. The MRS data were taken four weeks after operation (before radiotherapy) and every six months after the completion of RT. The N-acetyl aspartate, choline, creatine, and myo-inositol parameters were quantified, analyzed, and correlated to recurrence-free survival (RFS).

Results: The median RFS was 26.06 months. RFS was significantly worse in elderly patients (P = 0.001) along with the higher choline/creatine ratios at either baseline (P = 0.003) or six months post Radiotherapy (P = 0.042). Median RFS was 23 months in high choline/creatine levels ≥ 2 at 6 months after radiotherapy and 11 months for those with < 2 choline/creatine levels. There was a significant correlation of maximum difference of choline/creatine ratio with RFS (rho = 0.64, P = 0.045).

Conclusion: Age and choline/creatine ratio are strong independent prognostic factors in high grade gliomas.

No MeSH data available.


Related in: MedlinePlus