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Different Plaque Composition and Progression in Patients with Stable and Unstable Coronary Syndromes Evaluated by Cardiac CT.

Dalager MG, Bøttcher M, Thygesen J, Andersen G, Bøtker HE - Biomed Res Int (2015)

Bottom Line: The number of segments with significant stenosis did not differ between the groups, but noncalcified plaques more frequently caused significant stenoses in UAP/n-STEMI than in SAP patients (P = 0.0002).However, composition was altered as the number of segments with noncalcified plaques decreased (P = 0.018).IVUS data confirmed the CT findings.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.

ABSTRACT

Objective: To compare the quantity, subtype, and progression of atherosclerosis by cardiac computed tomography (CT) and intravascular ultrasound (IVUS) in patients with stable (SAP) and unstable angina pectoris or non-ST-elevation myocardial infarction (UAP/n-STEMI).

Methods: Forty patients with SAP and 20 with UAP/n-STEMI underwent cardiac CT and angiography with IVUS at baseline and after one year. Atherosclerotic segments were divided into calcified, mixed, or noncalcified subtypes, and significant stenoses were registered.

Results: Thirty-two SAP and 15 UAP/n-STEMI patients completed the CT follow-up. At baseline, the number of atherosclerotic segments was higher in UAP/n-STEMI than in SAP (P = 0.039). UAP/n-STEMI patients had more segments with noncalcified plaques (P = 0.0005) whereas SAP patients had more segments with calcified plaques (P = 0.013). The number of segments with significant stenosis did not differ between the groups, but noncalcified plaques more frequently caused significant stenoses in UAP/n-STEMI than in SAP patients (P = 0.0002). After one year the number of segments with atherosclerosis increased in SAP patients (P = 0.0001). The number of atherosclerotic segments remained unchanged in UAP/n-STEMI patients. However, composition was altered as the number of segments with noncalcified plaques decreased (P = 0.018). IVUS data confirmed the CT findings.

Conclusion: Quantity, subtype, and progression of atherosclerosis differ between SAP and UAP/n-STEMI patients.

No MeSH data available.


Related in: MedlinePlus

The development of atherosclerosis during one year of follw-up, ((a) stable angina pectoris (SAP) and (b) unstable angina pectoris/non-ST-elevation myocardial infarction (UAP/n-STEMI)). The first two rows display all segments with atherosclerotic plaques; the next six rows display the allocation of the segments into the three atherosclerotic subtypes.
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Related In: Results  -  Collection


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fig3: The development of atherosclerosis during one year of follw-up, ((a) stable angina pectoris (SAP) and (b) unstable angina pectoris/non-ST-elevation myocardial infarction (UAP/n-STEMI)). The first two rows display all segments with atherosclerotic plaques; the next six rows display the allocation of the segments into the three atherosclerotic subtypes.

Mentions: Figure 3(a) shows the development of atherosclerosis in the SAP group, and Figure 3(b) in the UAP/n-STEMI group. After one year we found an increase in the number of segments with disease in the SAP group (5.3 ± 0.71 versus 6.5 ± 0.61, P = 0.0001 (n = 32)). This was caused by an increase in the number of segments containing mixed plaques (1.5 ± 0.53 versus 2.2 ± 0.62, P = 0.055). We detected no difference in the number of segments with disease in the UAP/n-STEMI group after one year (6.1 ± 1.1 and 6.3 ± 1.2, P = 0.42 (n = 15)). However, in this group we observed marked differences in the subtype of atherosclerosis, with a decrease in the number of segments with noncalcified plaques (3.0 ± 1.0 versus 2.1 ± 0.8, P = 0.018). We detected no difference in the number of atherosclerotic segments at baseline between the group of patients not completing the follow-up scan and the group of patients completing follow-up (P = 0.27).


Different Plaque Composition and Progression in Patients with Stable and Unstable Coronary Syndromes Evaluated by Cardiac CT.

Dalager MG, Bøttcher M, Thygesen J, Andersen G, Bøtker HE - Biomed Res Int (2015)

The development of atherosclerosis during one year of follw-up, ((a) stable angina pectoris (SAP) and (b) unstable angina pectoris/non-ST-elevation myocardial infarction (UAP/n-STEMI)). The first two rows display all segments with atherosclerotic plaques; the next six rows display the allocation of the segments into the three atherosclerotic subtypes.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4538323&req=5

fig3: The development of atherosclerosis during one year of follw-up, ((a) stable angina pectoris (SAP) and (b) unstable angina pectoris/non-ST-elevation myocardial infarction (UAP/n-STEMI)). The first two rows display all segments with atherosclerotic plaques; the next six rows display the allocation of the segments into the three atherosclerotic subtypes.
Mentions: Figure 3(a) shows the development of atherosclerosis in the SAP group, and Figure 3(b) in the UAP/n-STEMI group. After one year we found an increase in the number of segments with disease in the SAP group (5.3 ± 0.71 versus 6.5 ± 0.61, P = 0.0001 (n = 32)). This was caused by an increase in the number of segments containing mixed plaques (1.5 ± 0.53 versus 2.2 ± 0.62, P = 0.055). We detected no difference in the number of segments with disease in the UAP/n-STEMI group after one year (6.1 ± 1.1 and 6.3 ± 1.2, P = 0.42 (n = 15)). However, in this group we observed marked differences in the subtype of atherosclerosis, with a decrease in the number of segments with noncalcified plaques (3.0 ± 1.0 versus 2.1 ± 0.8, P = 0.018). We detected no difference in the number of atherosclerotic segments at baseline between the group of patients not completing the follow-up scan and the group of patients completing follow-up (P = 0.27).

Bottom Line: The number of segments with significant stenosis did not differ between the groups, but noncalcified plaques more frequently caused significant stenoses in UAP/n-STEMI than in SAP patients (P = 0.0002).However, composition was altered as the number of segments with noncalcified plaques decreased (P = 0.018).IVUS data confirmed the CT findings.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.

ABSTRACT

Objective: To compare the quantity, subtype, and progression of atherosclerosis by cardiac computed tomography (CT) and intravascular ultrasound (IVUS) in patients with stable (SAP) and unstable angina pectoris or non-ST-elevation myocardial infarction (UAP/n-STEMI).

Methods: Forty patients with SAP and 20 with UAP/n-STEMI underwent cardiac CT and angiography with IVUS at baseline and after one year. Atherosclerotic segments were divided into calcified, mixed, or noncalcified subtypes, and significant stenoses were registered.

Results: Thirty-two SAP and 15 UAP/n-STEMI patients completed the CT follow-up. At baseline, the number of atherosclerotic segments was higher in UAP/n-STEMI than in SAP (P = 0.039). UAP/n-STEMI patients had more segments with noncalcified plaques (P = 0.0005) whereas SAP patients had more segments with calcified plaques (P = 0.013). The number of segments with significant stenosis did not differ between the groups, but noncalcified plaques more frequently caused significant stenoses in UAP/n-STEMI than in SAP patients (P = 0.0002). After one year the number of segments with atherosclerosis increased in SAP patients (P = 0.0001). The number of atherosclerotic segments remained unchanged in UAP/n-STEMI patients. However, composition was altered as the number of segments with noncalcified plaques decreased (P = 0.018). IVUS data confirmed the CT findings.

Conclusion: Quantity, subtype, and progression of atherosclerosis differ between SAP and UAP/n-STEMI patients.

No MeSH data available.


Related in: MedlinePlus