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Different Plaque Composition and Progression in Patients with Stable and Unstable Coronary Syndromes Evaluated by Cardiac CT.

Dalager MG, Bøttcher M, Thygesen J, Andersen G, Bøtker HE - Biomed Res Int (2015)

Bottom Line: Atherosclerotic segments were divided into calcified, mixed, or noncalcified subtypes, and significant stenoses were registered.The number of segments with significant stenosis did not differ between the groups, but noncalcified plaques more frequently caused significant stenoses in UAP/n-STEMI than in SAP patients (P = 0.0002).However, composition was altered as the number of segments with noncalcified plaques decreased (P = 0.018).

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.

ABSTRACT

Objective: To compare the quantity, subtype, and progression of atherosclerosis by cardiac computed tomography (CT) and intravascular ultrasound (IVUS) in patients with stable (SAP) and unstable angina pectoris or non-ST-elevation myocardial infarction (UAP/n-STEMI).

Methods: Forty patients with SAP and 20 with UAP/n-STEMI underwent cardiac CT and angiography with IVUS at baseline and after one year. Atherosclerotic segments were divided into calcified, mixed, or noncalcified subtypes, and significant stenoses were registered.

Results: Thirty-two SAP and 15 UAP/n-STEMI patients completed the CT follow-up. At baseline, the number of atherosclerotic segments was higher in UAP/n-STEMI than in SAP (P = 0.039). UAP/n-STEMI patients had more segments with noncalcified plaques (P = 0.0005) whereas SAP patients had more segments with calcified plaques (P = 0.013). The number of segments with significant stenosis did not differ between the groups, but noncalcified plaques more frequently caused significant stenoses in UAP/n-STEMI than in SAP patients (P = 0.0002). After one year the number of segments with atherosclerosis increased in SAP patients (P = 0.0001). The number of atherosclerotic segments remained unchanged in UAP/n-STEMI patients. However, composition was altered as the number of segments with noncalcified plaques decreased (P = 0.018). IVUS data confirmed the CT findings.

Conclusion: Quantity, subtype, and progression of atherosclerosis differ between SAP and UAP/n-STEMI patients.

No MeSH data available.


Related in: MedlinePlus

The development of atherosclerosis during one year of follw-up, ((a) stable angina pectoris (SAP) and (b) unstable angina pectoris/non-ST-elevation myocardial infarction (UAP/n-STEMI)). The first two rows display all segments with atherosclerotic plaques; the next six rows display the allocation of the segments into the three atherosclerotic subtypes.
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fig3: The development of atherosclerosis during one year of follw-up, ((a) stable angina pectoris (SAP) and (b) unstable angina pectoris/non-ST-elevation myocardial infarction (UAP/n-STEMI)). The first two rows display all segments with atherosclerotic plaques; the next six rows display the allocation of the segments into the three atherosclerotic subtypes.

Mentions: Figure 3(a) shows the development of atherosclerosis in the SAP group, and Figure 3(b) in the UAP/n-STEMI group. After one year we found an increase in the number of segments with disease in the SAP group (5.3 ± 0.71 versus 6.5 ± 0.61, P = 0.0001 (n = 32)). This was caused by an increase in the number of segments containing mixed plaques (1.5 ± 0.53 versus 2.2 ± 0.62, P = 0.055). We detected no difference in the number of segments with disease in the UAP/n-STEMI group after one year (6.1 ± 1.1 and 6.3 ± 1.2, P = 0.42 (n = 15)). However, in this group we observed marked differences in the subtype of atherosclerosis, with a decrease in the number of segments with noncalcified plaques (3.0 ± 1.0 versus 2.1 ± 0.8, P = 0.018). We detected no difference in the number of atherosclerotic segments at baseline between the group of patients not completing the follow-up scan and the group of patients completing follow-up (P = 0.27).


Different Plaque Composition and Progression in Patients with Stable and Unstable Coronary Syndromes Evaluated by Cardiac CT.

Dalager MG, Bøttcher M, Thygesen J, Andersen G, Bøtker HE - Biomed Res Int (2015)

The development of atherosclerosis during one year of follw-up, ((a) stable angina pectoris (SAP) and (b) unstable angina pectoris/non-ST-elevation myocardial infarction (UAP/n-STEMI)). The first two rows display all segments with atherosclerotic plaques; the next six rows display the allocation of the segments into the three atherosclerotic subtypes.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4538323&req=5

fig3: The development of atherosclerosis during one year of follw-up, ((a) stable angina pectoris (SAP) and (b) unstable angina pectoris/non-ST-elevation myocardial infarction (UAP/n-STEMI)). The first two rows display all segments with atherosclerotic plaques; the next six rows display the allocation of the segments into the three atherosclerotic subtypes.
Mentions: Figure 3(a) shows the development of atherosclerosis in the SAP group, and Figure 3(b) in the UAP/n-STEMI group. After one year we found an increase in the number of segments with disease in the SAP group (5.3 ± 0.71 versus 6.5 ± 0.61, P = 0.0001 (n = 32)). This was caused by an increase in the number of segments containing mixed plaques (1.5 ± 0.53 versus 2.2 ± 0.62, P = 0.055). We detected no difference in the number of segments with disease in the UAP/n-STEMI group after one year (6.1 ± 1.1 and 6.3 ± 1.2, P = 0.42 (n = 15)). However, in this group we observed marked differences in the subtype of atherosclerosis, with a decrease in the number of segments with noncalcified plaques (3.0 ± 1.0 versus 2.1 ± 0.8, P = 0.018). We detected no difference in the number of atherosclerotic segments at baseline between the group of patients not completing the follow-up scan and the group of patients completing follow-up (P = 0.27).

Bottom Line: Atherosclerotic segments were divided into calcified, mixed, or noncalcified subtypes, and significant stenoses were registered.The number of segments with significant stenosis did not differ between the groups, but noncalcified plaques more frequently caused significant stenoses in UAP/n-STEMI than in SAP patients (P = 0.0002).However, composition was altered as the number of segments with noncalcified plaques decreased (P = 0.018).

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.

ABSTRACT

Objective: To compare the quantity, subtype, and progression of atherosclerosis by cardiac computed tomography (CT) and intravascular ultrasound (IVUS) in patients with stable (SAP) and unstable angina pectoris or non-ST-elevation myocardial infarction (UAP/n-STEMI).

Methods: Forty patients with SAP and 20 with UAP/n-STEMI underwent cardiac CT and angiography with IVUS at baseline and after one year. Atherosclerotic segments were divided into calcified, mixed, or noncalcified subtypes, and significant stenoses were registered.

Results: Thirty-two SAP and 15 UAP/n-STEMI patients completed the CT follow-up. At baseline, the number of atherosclerotic segments was higher in UAP/n-STEMI than in SAP (P = 0.039). UAP/n-STEMI patients had more segments with noncalcified plaques (P = 0.0005) whereas SAP patients had more segments with calcified plaques (P = 0.013). The number of segments with significant stenosis did not differ between the groups, but noncalcified plaques more frequently caused significant stenoses in UAP/n-STEMI than in SAP patients (P = 0.0002). After one year the number of segments with atherosclerosis increased in SAP patients (P = 0.0001). The number of atherosclerotic segments remained unchanged in UAP/n-STEMI patients. However, composition was altered as the number of segments with noncalcified plaques decreased (P = 0.018). IVUS data confirmed the CT findings.

Conclusion: Quantity, subtype, and progression of atherosclerosis differ between SAP and UAP/n-STEMI patients.

No MeSH data available.


Related in: MedlinePlus