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Different Plaque Composition and Progression in Patients with Stable and Unstable Coronary Syndromes Evaluated by Cardiac CT.

Dalager MG, Bøttcher M, Thygesen J, Andersen G, Bøtker HE - Biomed Res Int (2015)

Bottom Line: The number of segments with significant stenosis did not differ between the groups, but noncalcified plaques more frequently caused significant stenoses in UAP/n-STEMI than in SAP patients (P = 0.0002).However, composition was altered as the number of segments with noncalcified plaques decreased (P = 0.018).IVUS data confirmed the CT findings.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.

ABSTRACT

Objective: To compare the quantity, subtype, and progression of atherosclerosis by cardiac computed tomography (CT) and intravascular ultrasound (IVUS) in patients with stable (SAP) and unstable angina pectoris or non-ST-elevation myocardial infarction (UAP/n-STEMI).

Methods: Forty patients with SAP and 20 with UAP/n-STEMI underwent cardiac CT and angiography with IVUS at baseline and after one year. Atherosclerotic segments were divided into calcified, mixed, or noncalcified subtypes, and significant stenoses were registered.

Results: Thirty-two SAP and 15 UAP/n-STEMI patients completed the CT follow-up. At baseline, the number of atherosclerotic segments was higher in UAP/n-STEMI than in SAP (P = 0.039). UAP/n-STEMI patients had more segments with noncalcified plaques (P = 0.0005) whereas SAP patients had more segments with calcified plaques (P = 0.013). The number of segments with significant stenosis did not differ between the groups, but noncalcified plaques more frequently caused significant stenoses in UAP/n-STEMI than in SAP patients (P = 0.0002). After one year the number of segments with atherosclerosis increased in SAP patients (P = 0.0001). The number of atherosclerotic segments remained unchanged in UAP/n-STEMI patients. However, composition was altered as the number of segments with noncalcified plaques decreased (P = 0.018). IVUS data confirmed the CT findings.

Conclusion: Quantity, subtype, and progression of atherosclerosis differ between SAP and UAP/n-STEMI patients.

No MeSH data available.


Related in: MedlinePlus

Mean number of segments with atherosclerosis in patients with stable angina pectoris (SAP) and patients with unstable angina pectoris/non-ST-elevation myocardial infarction (UAP/n-STEMI) at baseline. The first two rows display all segments with atherosclerotic plaques; the next six rows display the allocation of the segments into the three atherosclerotic subtypes.
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fig1: Mean number of segments with atherosclerosis in patients with stable angina pectoris (SAP) and patients with unstable angina pectoris/non-ST-elevation myocardial infarction (UAP/n-STEMI) at baseline. The first two rows display all segments with atherosclerotic plaques; the next six rows display the allocation of the segments into the three atherosclerotic subtypes.

Mentions: The distribution of segments with disease between the two patient groups is displayed in Figure 1. The number of coronary artery segments with atherosclerotic disease was higher in UAP/n-STEMI patients than in SAP patients (6.2 ± 0.85 versus 5.1 ± 0.69, P = 0.039). More segments with noncalcified plaques were found in the UAP group than in the SAP group (2.6 ± 0.77 versus 1.0 ± 0.41, P = 0.0005), while more segments containing calcified plaques were found in the SAP compared to the UAP/n-STEMI group (2.6 ± 0.66 versus 1.4 ± 0.63, P = 0.013). There was no difference in the number of segments with mixed plaques between the two patient groups, despite a tendency towards more segments with mixed plaques in the UAP/n-STEMI group (2.2 ± 0.65 versus 1.5 ± 0.46, P = 0.075).


Different Plaque Composition and Progression in Patients with Stable and Unstable Coronary Syndromes Evaluated by Cardiac CT.

Dalager MG, Bøttcher M, Thygesen J, Andersen G, Bøtker HE - Biomed Res Int (2015)

Mean number of segments with atherosclerosis in patients with stable angina pectoris (SAP) and patients with unstable angina pectoris/non-ST-elevation myocardial infarction (UAP/n-STEMI) at baseline. The first two rows display all segments with atherosclerotic plaques; the next six rows display the allocation of the segments into the three atherosclerotic subtypes.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4538323&req=5

fig1: Mean number of segments with atherosclerosis in patients with stable angina pectoris (SAP) and patients with unstable angina pectoris/non-ST-elevation myocardial infarction (UAP/n-STEMI) at baseline. The first two rows display all segments with atherosclerotic plaques; the next six rows display the allocation of the segments into the three atherosclerotic subtypes.
Mentions: The distribution of segments with disease between the two patient groups is displayed in Figure 1. The number of coronary artery segments with atherosclerotic disease was higher in UAP/n-STEMI patients than in SAP patients (6.2 ± 0.85 versus 5.1 ± 0.69, P = 0.039). More segments with noncalcified plaques were found in the UAP group than in the SAP group (2.6 ± 0.77 versus 1.0 ± 0.41, P = 0.0005), while more segments containing calcified plaques were found in the SAP compared to the UAP/n-STEMI group (2.6 ± 0.66 versus 1.4 ± 0.63, P = 0.013). There was no difference in the number of segments with mixed plaques between the two patient groups, despite a tendency towards more segments with mixed plaques in the UAP/n-STEMI group (2.2 ± 0.65 versus 1.5 ± 0.46, P = 0.075).

Bottom Line: The number of segments with significant stenosis did not differ between the groups, but noncalcified plaques more frequently caused significant stenoses in UAP/n-STEMI than in SAP patients (P = 0.0002).However, composition was altered as the number of segments with noncalcified plaques decreased (P = 0.018).IVUS data confirmed the CT findings.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.

ABSTRACT

Objective: To compare the quantity, subtype, and progression of atherosclerosis by cardiac computed tomography (CT) and intravascular ultrasound (IVUS) in patients with stable (SAP) and unstable angina pectoris or non-ST-elevation myocardial infarction (UAP/n-STEMI).

Methods: Forty patients with SAP and 20 with UAP/n-STEMI underwent cardiac CT and angiography with IVUS at baseline and after one year. Atherosclerotic segments were divided into calcified, mixed, or noncalcified subtypes, and significant stenoses were registered.

Results: Thirty-two SAP and 15 UAP/n-STEMI patients completed the CT follow-up. At baseline, the number of atherosclerotic segments was higher in UAP/n-STEMI than in SAP (P = 0.039). UAP/n-STEMI patients had more segments with noncalcified plaques (P = 0.0005) whereas SAP patients had more segments with calcified plaques (P = 0.013). The number of segments with significant stenosis did not differ between the groups, but noncalcified plaques more frequently caused significant stenoses in UAP/n-STEMI than in SAP patients (P = 0.0002). After one year the number of segments with atherosclerosis increased in SAP patients (P = 0.0001). The number of atherosclerotic segments remained unchanged in UAP/n-STEMI patients. However, composition was altered as the number of segments with noncalcified plaques decreased (P = 0.018). IVUS data confirmed the CT findings.

Conclusion: Quantity, subtype, and progression of atherosclerosis differ between SAP and UAP/n-STEMI patients.

No MeSH data available.


Related in: MedlinePlus