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A Retrospective Review of CyberKnife Stereotactic Body Radiotherapy for Adrenal Tumors (Primary and Metastatic): Winthrop University Hospital Experience.

Desai A, Rai H, Haas J, Witten M, Blacksburg S, Schneider JG - Front Oncol (2015)

Bottom Line: Stereotactic body radiotherapy (SBRT) is an ablative treatment option allowing larger doses to be delivered over a shorter period of time.Of the factors examined, the biological equivalent dose (BED) of radiation delivered was found to be the most important predictor of local adrenal tumor control.We conclude that CyberKnife-based SBRT is a safe, non-invasive modality that has broadened the therapeutic options for the treatment of isolated adrenal metastases.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology and Oncology, Winthrop University Hospital , Mineola, NY , USA.

ABSTRACT
The adrenal gland is a common site of cancer metastasis. Surgery remains a mainstay of treatment for solitary adrenal metastasis. For patients who cannot undergo surgery, radiation is an alternative option. Stereotactic body radiotherapy (SBRT) is an ablative treatment option allowing larger doses to be delivered over a shorter period of time. In this study, we report on our experience with the use of SBRT to treat adrenal metastases using CyberKnife technology. We retrospectively reviewed the Winthrop University radiation oncology data base to identify 14 patients for whom SBRT was administered to treat malignant adrenal disease. Of the factors examined, the biological equivalent dose (BED) of radiation delivered was found to be the most important predictor of local adrenal tumor control. We conclude that CyberKnife-based SBRT is a safe, non-invasive modality that has broadened the therapeutic options for the treatment of isolated adrenal metastases.

No MeSH data available.


Related in: MedlinePlus

Fifty-seven-year-old female with metastatic small cell lung cancer with limited biopsy proven painful recurrence in the right adrenal gland despite prior systemic therapy. Patient was treated to the right adrenal metastasis 3000 cGy in three fractions prescribed to the 82% isodose line. Both kidneys, spinal cord, and regional bowel were contoured.
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Figure 1: Fifty-seven-year-old female with metastatic small cell lung cancer with limited biopsy proven painful recurrence in the right adrenal gland despite prior systemic therapy. Patient was treated to the right adrenal metastasis 3000 cGy in three fractions prescribed to the 82% isodose line. Both kidneys, spinal cord, and regional bowel were contoured.

Mentions: Planning was performed using Multiplan (Accuray, Inc., Sunnyvale, CA, USA) inverse planning and delivered using the CyberKnife (Accuray, Inc.) with motion and respiratory tracking performed using the Synchrony system (Accuray, Inc.) Only the adrenal tumor was treated rather than the whole gland (Figure 1).


A Retrospective Review of CyberKnife Stereotactic Body Radiotherapy for Adrenal Tumors (Primary and Metastatic): Winthrop University Hospital Experience.

Desai A, Rai H, Haas J, Witten M, Blacksburg S, Schneider JG - Front Oncol (2015)

Fifty-seven-year-old female with metastatic small cell lung cancer with limited biopsy proven painful recurrence in the right adrenal gland despite prior systemic therapy. Patient was treated to the right adrenal metastasis 3000 cGy in three fractions prescribed to the 82% isodose line. Both kidneys, spinal cord, and regional bowel were contoured.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4538288&req=5

Figure 1: Fifty-seven-year-old female with metastatic small cell lung cancer with limited biopsy proven painful recurrence in the right adrenal gland despite prior systemic therapy. Patient was treated to the right adrenal metastasis 3000 cGy in three fractions prescribed to the 82% isodose line. Both kidneys, spinal cord, and regional bowel were contoured.
Mentions: Planning was performed using Multiplan (Accuray, Inc., Sunnyvale, CA, USA) inverse planning and delivered using the CyberKnife (Accuray, Inc.) with motion and respiratory tracking performed using the Synchrony system (Accuray, Inc.) Only the adrenal tumor was treated rather than the whole gland (Figure 1).

Bottom Line: Stereotactic body radiotherapy (SBRT) is an ablative treatment option allowing larger doses to be delivered over a shorter period of time.Of the factors examined, the biological equivalent dose (BED) of radiation delivered was found to be the most important predictor of local adrenal tumor control.We conclude that CyberKnife-based SBRT is a safe, non-invasive modality that has broadened the therapeutic options for the treatment of isolated adrenal metastases.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology and Oncology, Winthrop University Hospital , Mineola, NY , USA.

ABSTRACT
The adrenal gland is a common site of cancer metastasis. Surgery remains a mainstay of treatment for solitary adrenal metastasis. For patients who cannot undergo surgery, radiation is an alternative option. Stereotactic body radiotherapy (SBRT) is an ablative treatment option allowing larger doses to be delivered over a shorter period of time. In this study, we report on our experience with the use of SBRT to treat adrenal metastases using CyberKnife technology. We retrospectively reviewed the Winthrop University radiation oncology data base to identify 14 patients for whom SBRT was administered to treat malignant adrenal disease. Of the factors examined, the biological equivalent dose (BED) of radiation delivered was found to be the most important predictor of local adrenal tumor control. We conclude that CyberKnife-based SBRT is a safe, non-invasive modality that has broadened the therapeutic options for the treatment of isolated adrenal metastases.

No MeSH data available.


Related in: MedlinePlus