Limits...
Antiepileptic drugs and the risk of ischaemic stroke and myocardial infarction: a population-based cohort study.

Renoux C, Dell'Aniello S, Saarela O, Filion KB, Boivin JF - BMJ Open (2015)

Bottom Line: However, current use of inducing AEDs for ≥ 24 months was associated with a 46% increased risk of MI (RR=1.46, 95% CI 1.15 to 1.85) compared with the same duration of non-inducing AED, corresponding to a risk difference of 1.39/1000 (95% CI 0.33 to 2.45) persons per year.Current use of inhibiting AED was associated with a decreased risk of MI (RR=0.81, 95% CI 0.66 to 1.00).In contrast, use of inhibiting AEDs was associated with a decreased risk of MI.

View Article: PubMed Central - PubMed

Affiliation: Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada Department of Neurology and Neurosurgery, McGill University, Montréal, Québec, Canada Department of Epidemiology and Biostatistics, McGill University, Montréal, Québec, Canada.

No MeSH data available.


Related in: MedlinePlus

Adjusted rate ratios of ischaemic stroke and myocardial infarction associated with current use of inhibiting AEDs compared with non-inducing AEDs, stratified by indication and duration of use. IE, inducing AED; INHE, inhibiting AED; NIE, non-inducing AED; RR, rate ratio.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4538287&req=5

BMJOPEN2015008365F3: Adjusted rate ratios of ischaemic stroke and myocardial infarction associated with current use of inhibiting AEDs compared with non-inducing AEDs, stratified by indication and duration of use. IE, inducing AED; INHE, inhibiting AED; NIE, non-inducing AED; RR, rate ratio.

Mentions: Current use of inhibiting AED was not associated with an increased risk of ischaemic stroke (RR 1.13 (95% CI 0.96 to 1.33)) relative to current use of non-inducing AED and a non-statistically significant decreased risk of MI (RR 0.81 (95% CI 0.66 to 1.00); table 2). When stratified by duration of use, there was no clear pattern of association between the risk of ischaemic stroke or MI with longer duration of use of inhibiting AED (figure 3).


Antiepileptic drugs and the risk of ischaemic stroke and myocardial infarction: a population-based cohort study.

Renoux C, Dell'Aniello S, Saarela O, Filion KB, Boivin JF - BMJ Open (2015)

Adjusted rate ratios of ischaemic stroke and myocardial infarction associated with current use of inhibiting AEDs compared with non-inducing AEDs, stratified by indication and duration of use. IE, inducing AED; INHE, inhibiting AED; NIE, non-inducing AED; RR, rate ratio.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4538287&req=5

BMJOPEN2015008365F3: Adjusted rate ratios of ischaemic stroke and myocardial infarction associated with current use of inhibiting AEDs compared with non-inducing AEDs, stratified by indication and duration of use. IE, inducing AED; INHE, inhibiting AED; NIE, non-inducing AED; RR, rate ratio.
Mentions: Current use of inhibiting AED was not associated with an increased risk of ischaemic stroke (RR 1.13 (95% CI 0.96 to 1.33)) relative to current use of non-inducing AED and a non-statistically significant decreased risk of MI (RR 0.81 (95% CI 0.66 to 1.00); table 2). When stratified by duration of use, there was no clear pattern of association between the risk of ischaemic stroke or MI with longer duration of use of inhibiting AED (figure 3).

Bottom Line: However, current use of inducing AEDs for ≥ 24 months was associated with a 46% increased risk of MI (RR=1.46, 95% CI 1.15 to 1.85) compared with the same duration of non-inducing AED, corresponding to a risk difference of 1.39/1000 (95% CI 0.33 to 2.45) persons per year.Current use of inhibiting AED was associated with a decreased risk of MI (RR=0.81, 95% CI 0.66 to 1.00).In contrast, use of inhibiting AEDs was associated with a decreased risk of MI.

View Article: PubMed Central - PubMed

Affiliation: Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada Department of Neurology and Neurosurgery, McGill University, Montréal, Québec, Canada Department of Epidemiology and Biostatistics, McGill University, Montréal, Québec, Canada.

No MeSH data available.


Related in: MedlinePlus