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Antiepileptic drugs and the risk of ischaemic stroke and myocardial infarction: a population-based cohort study.

Renoux C, Dell'Aniello S, Saarela O, Filion KB, Boivin JF - BMJ Open (2015)

Bottom Line: However, current use of inducing AEDs for ≥ 24 months was associated with a 46% increased risk of MI (RR=1.46, 95% CI 1.15 to 1.85) compared with the same duration of non-inducing AED, corresponding to a risk difference of 1.39/1000 (95% CI 0.33 to 2.45) persons per year.Current use of inhibiting AED was associated with a decreased risk of MI (RR=0.81, 95% CI 0.66 to 1.00).In contrast, use of inhibiting AEDs was associated with a decreased risk of MI.

View Article: PubMed Central - PubMed

Affiliation: Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada Department of Neurology and Neurosurgery, McGill University, Montréal, Québec, Canada Department of Epidemiology and Biostatistics, McGill University, Montréal, Québec, Canada.

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Related in: MedlinePlus

Adjusted rate ratios of ischaemic stroke and myocardial infarction associated with current use of inducing AEDs compared with non-inducing AEDs, stratified by indication and duration of use. AED, antiepileptic drug; IE, inducing AED; INHE, inhibiting AED; NIE, non-inducing AED; RR, rate ratio.
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BMJOPEN2015008365F2: Adjusted rate ratios of ischaemic stroke and myocardial infarction associated with current use of inducing AEDs compared with non-inducing AEDs, stratified by indication and duration of use. AED, antiepileptic drug; IE, inducing AED; INHE, inhibiting AED; NIE, non-inducing AED; RR, rate ratio.

Mentions: Current use of inducing AED was associated with a small increased risk of ischaemic stroke (RR 1.16 (95% CI 1.02 to 1.33)) relative to current use of non-inducing AED and no increased risk of MI (RR 1.12 (95% CI 0.97 to 1.30); table 2). When stratified by indication, the increased risk of stroke was mainly driven by a 47% increased risk in the other/missing category (figure 2). The rate of stroke and MI did not vary according to the different inducing AED molecules (data not shown). When stratified by duration of use, there was no clear increased risk of ischaemic stroke with longer duration of current use of inducing AED (figure 2). However, there was an increased risk of MI with longer duration of use. Current inducing AED use of more than 24 months was associated with a 46% increased risk of MI (RR 1.46 (95% CI 1.15 to 1.85)) compared with the same duration of non-inducing AED use, corresponding to an absolute adjusted RD of 1.39/1000 (95% CI 0.33 to 2.45) persons per year.


Antiepileptic drugs and the risk of ischaemic stroke and myocardial infarction: a population-based cohort study.

Renoux C, Dell'Aniello S, Saarela O, Filion KB, Boivin JF - BMJ Open (2015)

Adjusted rate ratios of ischaemic stroke and myocardial infarction associated with current use of inducing AEDs compared with non-inducing AEDs, stratified by indication and duration of use. AED, antiepileptic drug; IE, inducing AED; INHE, inhibiting AED; NIE, non-inducing AED; RR, rate ratio.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4538287&req=5

BMJOPEN2015008365F2: Adjusted rate ratios of ischaemic stroke and myocardial infarction associated with current use of inducing AEDs compared with non-inducing AEDs, stratified by indication and duration of use. AED, antiepileptic drug; IE, inducing AED; INHE, inhibiting AED; NIE, non-inducing AED; RR, rate ratio.
Mentions: Current use of inducing AED was associated with a small increased risk of ischaemic stroke (RR 1.16 (95% CI 1.02 to 1.33)) relative to current use of non-inducing AED and no increased risk of MI (RR 1.12 (95% CI 0.97 to 1.30); table 2). When stratified by indication, the increased risk of stroke was mainly driven by a 47% increased risk in the other/missing category (figure 2). The rate of stroke and MI did not vary according to the different inducing AED molecules (data not shown). When stratified by duration of use, there was no clear increased risk of ischaemic stroke with longer duration of current use of inducing AED (figure 2). However, there was an increased risk of MI with longer duration of use. Current inducing AED use of more than 24 months was associated with a 46% increased risk of MI (RR 1.46 (95% CI 1.15 to 1.85)) compared with the same duration of non-inducing AED use, corresponding to an absolute adjusted RD of 1.39/1000 (95% CI 0.33 to 2.45) persons per year.

Bottom Line: However, current use of inducing AEDs for ≥ 24 months was associated with a 46% increased risk of MI (RR=1.46, 95% CI 1.15 to 1.85) compared with the same duration of non-inducing AED, corresponding to a risk difference of 1.39/1000 (95% CI 0.33 to 2.45) persons per year.Current use of inhibiting AED was associated with a decreased risk of MI (RR=0.81, 95% CI 0.66 to 1.00).In contrast, use of inhibiting AEDs was associated with a decreased risk of MI.

View Article: PubMed Central - PubMed

Affiliation: Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada Department of Neurology and Neurosurgery, McGill University, Montréal, Québec, Canada Department of Epidemiology and Biostatistics, McGill University, Montréal, Québec, Canada.

No MeSH data available.


Related in: MedlinePlus