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Should HFE p.C282Y homozygotes with moderately elevated serum ferritin be treated? A randomised controlled trial comparing iron reduction with sham treatment (Mi-iron).

Ong SY, Dolling L, Dixon JL, Nicoll AJ, Gurrin LC, Wolthuizen M, Wood EM, Anderson GJ, Ramm GA, Allen KJ, Olynyk JK, Crawford D, Kava J, Ramm LE, Gow P, Durrant S, Powell LW, Delatycki MB - BMJ Open (2015)

Bottom Line: Patients are blinded to all procedures.Patient reported outcome measures are the Modified Fatigue Impact Scale (MFIS-primary outcome), Hospital Anxiety and Depression Scale (HADS), Medical Outcomes Study 36-item short form V.2 (SF36v2) and Arthritis Impact Measurement Scale 2 short form (AIMS2-SF).This study has been approved by the Human Research Ethics Committees of Austin Health, Royal Melbourne Hospital and Royal Brisbane and Women's Hospital.

View Article: PubMed Central - PubMed

Affiliation: Bruce Lefroy Centre, Murdoch Childrens Research Institute, Parkville, Victoria, Australia Department of Medicine, The University of Melbourne, Parkville, Victoria, Australia.

No MeSH data available.


Related in: MedlinePlus

Equation to estimate postcollection haematocrit (Hct post) based on total blood volume (TBV) using Nadler's fomula.17 Adopted from the Haemonetics MCS Plus apheresis system manual. TBV, total blood volume; RBC, red blood cell; Hct, haematocrit.
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BMJOPEN2015008938F3: Equation to estimate postcollection haematocrit (Hct post) based on total blood volume (TBV) using Nadler's fomula.17 Adopted from the Haemonetics MCS Plus apheresis system manual. TBV, total blood volume; RBC, red blood cell; Hct, haematocrit.

Mentions: Treatments are administered every 3 weeks. The volume of RBCs/plasma removed is individualised based on the individual's blood volume and haematocrit. Haematocrit is measured at the start of each erythrocytapheresis treatment while in the sham treatment group, mock blood tests are taken to ensure the participant's experience is identical irrespective of the treatment group to which they have been randomised. The volume removed is calculated based on the height, weight, pretreatment haematocrit and the target haematocrit (30–35%; figure 3). Treatments are ceased in the treatment group when SF is below 300 µg/L. For the sham group, the calculated number of treatments is equivalent to as if their SF was normalised in the RBC group.


Should HFE p.C282Y homozygotes with moderately elevated serum ferritin be treated? A randomised controlled trial comparing iron reduction with sham treatment (Mi-iron).

Ong SY, Dolling L, Dixon JL, Nicoll AJ, Gurrin LC, Wolthuizen M, Wood EM, Anderson GJ, Ramm GA, Allen KJ, Olynyk JK, Crawford D, Kava J, Ramm LE, Gow P, Durrant S, Powell LW, Delatycki MB - BMJ Open (2015)

Equation to estimate postcollection haematocrit (Hct post) based on total blood volume (TBV) using Nadler's fomula.17 Adopted from the Haemonetics MCS Plus apheresis system manual. TBV, total blood volume; RBC, red blood cell; Hct, haematocrit.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4538285&req=5

BMJOPEN2015008938F3: Equation to estimate postcollection haematocrit (Hct post) based on total blood volume (TBV) using Nadler's fomula.17 Adopted from the Haemonetics MCS Plus apheresis system manual. TBV, total blood volume; RBC, red blood cell; Hct, haematocrit.
Mentions: Treatments are administered every 3 weeks. The volume of RBCs/plasma removed is individualised based on the individual's blood volume and haematocrit. Haematocrit is measured at the start of each erythrocytapheresis treatment while in the sham treatment group, mock blood tests are taken to ensure the participant's experience is identical irrespective of the treatment group to which they have been randomised. The volume removed is calculated based on the height, weight, pretreatment haematocrit and the target haematocrit (30–35%; figure 3). Treatments are ceased in the treatment group when SF is below 300 µg/L. For the sham group, the calculated number of treatments is equivalent to as if their SF was normalised in the RBC group.

Bottom Line: Patients are blinded to all procedures.Patient reported outcome measures are the Modified Fatigue Impact Scale (MFIS-primary outcome), Hospital Anxiety and Depression Scale (HADS), Medical Outcomes Study 36-item short form V.2 (SF36v2) and Arthritis Impact Measurement Scale 2 short form (AIMS2-SF).This study has been approved by the Human Research Ethics Committees of Austin Health, Royal Melbourne Hospital and Royal Brisbane and Women's Hospital.

View Article: PubMed Central - PubMed

Affiliation: Bruce Lefroy Centre, Murdoch Childrens Research Institute, Parkville, Victoria, Australia Department of Medicine, The University of Melbourne, Parkville, Victoria, Australia.

No MeSH data available.


Related in: MedlinePlus