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Should HFE p.C282Y homozygotes with moderately elevated serum ferritin be treated? A randomised controlled trial comparing iron reduction with sham treatment (Mi-iron).

Ong SY, Dolling L, Dixon JL, Nicoll AJ, Gurrin LC, Wolthuizen M, Wood EM, Anderson GJ, Ramm GA, Allen KJ, Olynyk JK, Crawford D, Kava J, Ramm LE, Gow P, Durrant S, Powell LW, Delatycki MB - BMJ Open (2015)

Bottom Line: Patients are blinded to all procedures.Patient reported outcome measures are the Modified Fatigue Impact Scale (MFIS-primary outcome), Hospital Anxiety and Depression Scale (HADS), Medical Outcomes Study 36-item short form V.2 (SF36v2) and Arthritis Impact Measurement Scale 2 short form (AIMS2-SF).This study has been approved by the Human Research Ethics Committees of Austin Health, Royal Melbourne Hospital and Royal Brisbane and Women's Hospital.

View Article: PubMed Central - PubMed

Affiliation: Bruce Lefroy Centre, Murdoch Childrens Research Institute, Parkville, Victoria, Australia Department of Medicine, The University of Melbourne, Parkville, Victoria, Australia.

No MeSH data available.


Related in: MedlinePlus

Flow chart of methodology for the Mi-iron Study. TS, transferrin saturation; SF, serum ferritin; MFIS, Modified Fatigue Impact Scale; SF36v2, Medical Outcomes Study 36-item short form V.2; HADS, Hospital Anxiety and Depression scale; AIMS2-SF, Arthritis Impact Measurement Scales 2 short form; TE, transient elastography.
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BMJOPEN2015008938F1: Flow chart of methodology for the Mi-iron Study. TS, transferrin saturation; SF, serum ferritin; MFIS, Modified Fatigue Impact Scale; SF36v2, Medical Outcomes Study 36-item short form V.2; HADS, Hospital Anxiety and Depression scale; AIMS2-SF, Arthritis Impact Measurement Scales 2 short form; TE, transient elastography.

Mentions: The Mi-iron (Moderately increased iron levels) study is a multicentre, randomised single-blinded trial being conducted in Victoria (Austin Hospital and the Royal Melbourne Hospital) and Queensland (Royal Brisbane and Women's Hospital) that started in August 2012 and is due to conclude in December 2015. FigureĀ 1 summarises the methodology of the Mi-iron Study.


Should HFE p.C282Y homozygotes with moderately elevated serum ferritin be treated? A randomised controlled trial comparing iron reduction with sham treatment (Mi-iron).

Ong SY, Dolling L, Dixon JL, Nicoll AJ, Gurrin LC, Wolthuizen M, Wood EM, Anderson GJ, Ramm GA, Allen KJ, Olynyk JK, Crawford D, Kava J, Ramm LE, Gow P, Durrant S, Powell LW, Delatycki MB - BMJ Open (2015)

Flow chart of methodology for the Mi-iron Study. TS, transferrin saturation; SF, serum ferritin; MFIS, Modified Fatigue Impact Scale; SF36v2, Medical Outcomes Study 36-item short form V.2; HADS, Hospital Anxiety and Depression scale; AIMS2-SF, Arthritis Impact Measurement Scales 2 short form; TE, transient elastography.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4538285&req=5

BMJOPEN2015008938F1: Flow chart of methodology for the Mi-iron Study. TS, transferrin saturation; SF, serum ferritin; MFIS, Modified Fatigue Impact Scale; SF36v2, Medical Outcomes Study 36-item short form V.2; HADS, Hospital Anxiety and Depression scale; AIMS2-SF, Arthritis Impact Measurement Scales 2 short form; TE, transient elastography.
Mentions: The Mi-iron (Moderately increased iron levels) study is a multicentre, randomised single-blinded trial being conducted in Victoria (Austin Hospital and the Royal Melbourne Hospital) and Queensland (Royal Brisbane and Women's Hospital) that started in August 2012 and is due to conclude in December 2015. FigureĀ 1 summarises the methodology of the Mi-iron Study.

Bottom Line: Patients are blinded to all procedures.Patient reported outcome measures are the Modified Fatigue Impact Scale (MFIS-primary outcome), Hospital Anxiety and Depression Scale (HADS), Medical Outcomes Study 36-item short form V.2 (SF36v2) and Arthritis Impact Measurement Scale 2 short form (AIMS2-SF).This study has been approved by the Human Research Ethics Committees of Austin Health, Royal Melbourne Hospital and Royal Brisbane and Women's Hospital.

View Article: PubMed Central - PubMed

Affiliation: Bruce Lefroy Centre, Murdoch Childrens Research Institute, Parkville, Victoria, Australia Department of Medicine, The University of Melbourne, Parkville, Victoria, Australia.

No MeSH data available.


Related in: MedlinePlus