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Cohort profile: systemic lupus erythematosus in Sweden: the Swedish Lupus Linkage (SLINK) cohort.

Arkema EV, Simard JF - BMJ Open (2015)

Bottom Line: We found geographic variability in the prevalence of SLE by county.We have also shown that being first-born confers a reduced odds of having SLE in childhood and early adulthood.While these updates are ongoing and additional follow-up accumulates, we are studying a number of outcomes in SLE, including stroke, pregnancy and death.

View Article: PubMed Central - PubMed

Affiliation: Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden.

No MeSH data available.


Related in: MedlinePlus

Study population schematic diagram for national Swedish register linkage from the first iteration. The updated linkage uses the Patient Register exclusively to identify systemic lupus erythematosus (SLE) cases.
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BMJOPEN2015008259F1: Study population schematic diagram for national Swedish register linkage from the first iteration. The updated linkage uses the Patient Register exclusively to identify systemic lupus erythematosus (SLE) cases.

Mentions: To be included in the study population, individuals were labelled as possible SLE cases based on the diagnosis of a single inpatient or outpatient visit, with the understanding that to reduce misclassification, validated algorithms will be used to define SLE cases in future research. Each possible SLE case was matched to five individuals randomly selected from the general population accounting for birth year, sex and county of residence. Similar to incidence density sampling, each general population comparator was restricted to be ‘free of disease’ (ie, have no SLE ICD codes in the Patient Register) before the date of the first observed SLE ICD code (index date) of their matched case (figure 1). As with similar sampling schemes in case–control studies, this does not preclude the general population comparators from developing and being diagnosed with SLE in the future. We are able to identify when this occurs using the longitudinal Patient Register data. The study population was then linked to the Multi-Generation Register to identify first-degree relatives of both the SLE and comparator populations.


Cohort profile: systemic lupus erythematosus in Sweden: the Swedish Lupus Linkage (SLINK) cohort.

Arkema EV, Simard JF - BMJ Open (2015)

Study population schematic diagram for national Swedish register linkage from the first iteration. The updated linkage uses the Patient Register exclusively to identify systemic lupus erythematosus (SLE) cases.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4538276&req=5

BMJOPEN2015008259F1: Study population schematic diagram for national Swedish register linkage from the first iteration. The updated linkage uses the Patient Register exclusively to identify systemic lupus erythematosus (SLE) cases.
Mentions: To be included in the study population, individuals were labelled as possible SLE cases based on the diagnosis of a single inpatient or outpatient visit, with the understanding that to reduce misclassification, validated algorithms will be used to define SLE cases in future research. Each possible SLE case was matched to five individuals randomly selected from the general population accounting for birth year, sex and county of residence. Similar to incidence density sampling, each general population comparator was restricted to be ‘free of disease’ (ie, have no SLE ICD codes in the Patient Register) before the date of the first observed SLE ICD code (index date) of their matched case (figure 1). As with similar sampling schemes in case–control studies, this does not preclude the general population comparators from developing and being diagnosed with SLE in the future. We are able to identify when this occurs using the longitudinal Patient Register data. The study population was then linked to the Multi-Generation Register to identify first-degree relatives of both the SLE and comparator populations.

Bottom Line: We found geographic variability in the prevalence of SLE by county.We have also shown that being first-born confers a reduced odds of having SLE in childhood and early adulthood.While these updates are ongoing and additional follow-up accumulates, we are studying a number of outcomes in SLE, including stroke, pregnancy and death.

View Article: PubMed Central - PubMed

Affiliation: Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden.

No MeSH data available.


Related in: MedlinePlus