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Retrospective study of the predictors of mortality and radiographic deterioration in 782 patients with nodular/bronchiectatic Mycobacterium avium complex lung disease.

Gochi M, Takayanagi N, Kanauchi T, Ishiguro T, Yanagisawa T, Sugita Y - BMJ Open (2015)

Bottom Line: In 536 patients with MAC-LD who were followed-up for more than 1 year, radiographic deterioration occurred in 221 (41.2%) patients and median time-to-radiographic deterioration was 9 years.A multivariate Cox proportional hazard model showed male sex, older age, body mass index <18.5 kg/m(2), absence of bloody sputum, hypoalbuminaemia and erythrocyte sedimentation rate >40 mm/h to be negative prognostic factors for all-cause mortality, and the presence of idiopathic pulmonary fibrosis, haemoglobin <11.3 mg/dL, C reactive protein >1.0 mg/dL and the presence of cavity to be negative prognostic factors for radiographic deterioration.Only 2.4% of patients with NB MAC-LD died from MAC-LD progression.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Saitama, Japan.

No MeSH data available.


Related in: MedlinePlus

Kaplan-Meier curves of the probability of no radiographic deterioration of patients with nodular/bronchiectatic Mycobacterium avium complex lung disease with or without cavity. Cumulative median time-to-radiographic deterioration was 9 years, and 5-year and 10-year radiographic deterioration rates were 39.1% and 54%, respectively. Median time-to-radiographic deterioration and 5-year and 10-year radiographic deterioration rate in the patients with cavity were 30 years, and 66.7% and 70.4%, versus 10 years, and 34.6% and 51.7%, in those without cavity, respectively (p<0.001).
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BMJOPEN2015008058F3: Kaplan-Meier curves of the probability of no radiographic deterioration of patients with nodular/bronchiectatic Mycobacterium avium complex lung disease with or without cavity. Cumulative median time-to-radiographic deterioration was 9 years, and 5-year and 10-year radiographic deterioration rates were 39.1% and 54%, respectively. Median time-to-radiographic deterioration and 5-year and 10-year radiographic deterioration rate in the patients with cavity were 30 years, and 66.7% and 70.4%, versus 10 years, and 34.6% and 51.7%, in those without cavity, respectively (p<0.001).

Mentions: Interobserver agreement regarding radiographic changes was good (κ, 0.862; 95%CI, 0.733 to 0.990). In 536 patients with MAC-LD whose follow-up was more than 1 year, radiographic deterioration occurred in 221 (41.2%) patients over a median follow-up period of 5 years (range, 1–30 years). Patients with cavity more frequently had lower BMI and elevation of inflammatory markers, and were more frequently treated with a regimen of 2–4 first-line drugs (table 4). Cumulative median time-to-radiographic deterioration was 9 years, and 5-year and 10-year rates of radiographic deterioration were 39.1% and 54%, respectively (figure 3). Median time-to-radiographic deterioration and 5-year and 10-year rates of radiographic deterioration in the patients with cavity were 3 years, and 66.7% and 70.4%, versus 10 years, and 34.6% and 51.7%, in those without cavity (p<0.001; figure 3). A multivariate Cox proportional hazard model showed the presence of idiopathic pulmonary fibrosis, Hb <11.3 mg/dL, CRP >1.0 mg/dL and the presence of cavity to be negative prognostic factors of radiographic deterioration (table 3).


Retrospective study of the predictors of mortality and radiographic deterioration in 782 patients with nodular/bronchiectatic Mycobacterium avium complex lung disease.

Gochi M, Takayanagi N, Kanauchi T, Ishiguro T, Yanagisawa T, Sugita Y - BMJ Open (2015)

Kaplan-Meier curves of the probability of no radiographic deterioration of patients with nodular/bronchiectatic Mycobacterium avium complex lung disease with or without cavity. Cumulative median time-to-radiographic deterioration was 9 years, and 5-year and 10-year radiographic deterioration rates were 39.1% and 54%, respectively. Median time-to-radiographic deterioration and 5-year and 10-year radiographic deterioration rate in the patients with cavity were 30 years, and 66.7% and 70.4%, versus 10 years, and 34.6% and 51.7%, in those without cavity, respectively (p<0.001).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4538251&req=5

BMJOPEN2015008058F3: Kaplan-Meier curves of the probability of no radiographic deterioration of patients with nodular/bronchiectatic Mycobacterium avium complex lung disease with or without cavity. Cumulative median time-to-radiographic deterioration was 9 years, and 5-year and 10-year radiographic deterioration rates were 39.1% and 54%, respectively. Median time-to-radiographic deterioration and 5-year and 10-year radiographic deterioration rate in the patients with cavity were 30 years, and 66.7% and 70.4%, versus 10 years, and 34.6% and 51.7%, in those without cavity, respectively (p<0.001).
Mentions: Interobserver agreement regarding radiographic changes was good (κ, 0.862; 95%CI, 0.733 to 0.990). In 536 patients with MAC-LD whose follow-up was more than 1 year, radiographic deterioration occurred in 221 (41.2%) patients over a median follow-up period of 5 years (range, 1–30 years). Patients with cavity more frequently had lower BMI and elevation of inflammatory markers, and were more frequently treated with a regimen of 2–4 first-line drugs (table 4). Cumulative median time-to-radiographic deterioration was 9 years, and 5-year and 10-year rates of radiographic deterioration were 39.1% and 54%, respectively (figure 3). Median time-to-radiographic deterioration and 5-year and 10-year rates of radiographic deterioration in the patients with cavity were 3 years, and 66.7% and 70.4%, versus 10 years, and 34.6% and 51.7%, in those without cavity (p<0.001; figure 3). A multivariate Cox proportional hazard model showed the presence of idiopathic pulmonary fibrosis, Hb <11.3 mg/dL, CRP >1.0 mg/dL and the presence of cavity to be negative prognostic factors of radiographic deterioration (table 3).

Bottom Line: In 536 patients with MAC-LD who were followed-up for more than 1 year, radiographic deterioration occurred in 221 (41.2%) patients and median time-to-radiographic deterioration was 9 years.A multivariate Cox proportional hazard model showed male sex, older age, body mass index <18.5 kg/m(2), absence of bloody sputum, hypoalbuminaemia and erythrocyte sedimentation rate >40 mm/h to be negative prognostic factors for all-cause mortality, and the presence of idiopathic pulmonary fibrosis, haemoglobin <11.3 mg/dL, C reactive protein >1.0 mg/dL and the presence of cavity to be negative prognostic factors for radiographic deterioration.Only 2.4% of patients with NB MAC-LD died from MAC-LD progression.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Saitama, Japan.

No MeSH data available.


Related in: MedlinePlus