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Retrospective study of the predictors of mortality and radiographic deterioration in 782 patients with nodular/bronchiectatic Mycobacterium avium complex lung disease.

Gochi M, Takayanagi N, Kanauchi T, Ishiguro T, Yanagisawa T, Sugita Y - BMJ Open (2015)

Bottom Line: In 536 patients with MAC-LD who were followed-up for more than 1 year, radiographic deterioration occurred in 221 (41.2%) patients and median time-to-radiographic deterioration was 9 years.A multivariate Cox proportional hazard model showed male sex, older age, body mass index <18.5 kg/m(2), absence of bloody sputum, hypoalbuminaemia and erythrocyte sedimentation rate >40 mm/h to be negative prognostic factors for all-cause mortality, and the presence of idiopathic pulmonary fibrosis, haemoglobin <11.3 mg/dL, C reactive protein >1.0 mg/dL and the presence of cavity to be negative prognostic factors for radiographic deterioration.Only 2.4% of patients with NB MAC-LD died from MAC-LD progression.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Saitama, Japan.

No MeSH data available.


Related in: MedlinePlus

Kaplan-Meier survival curves of Mycobacterium avium complex lung disease (MAC-LD) progression mortality of patients with nodular/bronchiectatic MAC-LD with or without cavity. Five-year and 10-year MAC-LD progression mortality rates were 2% and 4.8%, respectively. Five-year and 10-year MAC-LD progression mortality rates in the patients with cavity were 8.5% and 25.1%, versus 0.8% for each period in those without cavity, respectively (p<0.001).
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BMJOPEN2015008058F2: Kaplan-Meier survival curves of Mycobacterium avium complex lung disease (MAC-LD) progression mortality of patients with nodular/bronchiectatic MAC-LD with or without cavity. Five-year and 10-year MAC-LD progression mortality rates were 2% and 4.8%, respectively. Five-year and 10-year MAC-LD progression mortality rates in the patients with cavity were 8.5% and 25.1%, versus 0.8% for each period in those without cavity, respectively (p<0.001).

Mentions: Five-year and 10-year mortality rates from MAC-LD progression were 2% and 4.8%, respectively (figure 2). Respective 5-year and 10-year mortality rates from MAC-LD progression in the patients with cavity were 8.5% and 25.1%, vs 0.8% for each in those without cavity (p<0.001; figure 2). A multivariate Cox proportional hazard model showed older age, presence of cavity and therapy of 2–4 drugs to be negative prognostic factors (table 3).


Retrospective study of the predictors of mortality and radiographic deterioration in 782 patients with nodular/bronchiectatic Mycobacterium avium complex lung disease.

Gochi M, Takayanagi N, Kanauchi T, Ishiguro T, Yanagisawa T, Sugita Y - BMJ Open (2015)

Kaplan-Meier survival curves of Mycobacterium avium complex lung disease (MAC-LD) progression mortality of patients with nodular/bronchiectatic MAC-LD with or without cavity. Five-year and 10-year MAC-LD progression mortality rates were 2% and 4.8%, respectively. Five-year and 10-year MAC-LD progression mortality rates in the patients with cavity were 8.5% and 25.1%, versus 0.8% for each period in those without cavity, respectively (p<0.001).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4538251&req=5

BMJOPEN2015008058F2: Kaplan-Meier survival curves of Mycobacterium avium complex lung disease (MAC-LD) progression mortality of patients with nodular/bronchiectatic MAC-LD with or without cavity. Five-year and 10-year MAC-LD progression mortality rates were 2% and 4.8%, respectively. Five-year and 10-year MAC-LD progression mortality rates in the patients with cavity were 8.5% and 25.1%, versus 0.8% for each period in those without cavity, respectively (p<0.001).
Mentions: Five-year and 10-year mortality rates from MAC-LD progression were 2% and 4.8%, respectively (figure 2). Respective 5-year and 10-year mortality rates from MAC-LD progression in the patients with cavity were 8.5% and 25.1%, vs 0.8% for each in those without cavity (p<0.001; figure 2). A multivariate Cox proportional hazard model showed older age, presence of cavity and therapy of 2–4 drugs to be negative prognostic factors (table 3).

Bottom Line: In 536 patients with MAC-LD who were followed-up for more than 1 year, radiographic deterioration occurred in 221 (41.2%) patients and median time-to-radiographic deterioration was 9 years.A multivariate Cox proportional hazard model showed male sex, older age, body mass index <18.5 kg/m(2), absence of bloody sputum, hypoalbuminaemia and erythrocyte sedimentation rate >40 mm/h to be negative prognostic factors for all-cause mortality, and the presence of idiopathic pulmonary fibrosis, haemoglobin <11.3 mg/dL, C reactive protein >1.0 mg/dL and the presence of cavity to be negative prognostic factors for radiographic deterioration.Only 2.4% of patients with NB MAC-LD died from MAC-LD progression.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Saitama, Japan.

No MeSH data available.


Related in: MedlinePlus