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Retrospective study of the predictors of mortality and radiographic deterioration in 782 patients with nodular/bronchiectatic Mycobacterium avium complex lung disease.

Gochi M, Takayanagi N, Kanauchi T, Ishiguro T, Yanagisawa T, Sugita Y - BMJ Open (2015)

Bottom Line: In 536 patients with MAC-LD who were followed-up for more than 1 year, radiographic deterioration occurred in 221 (41.2%) patients and median time-to-radiographic deterioration was 9 years.A multivariate Cox proportional hazard model showed male sex, older age, body mass index <18.5 kg/m(2), absence of bloody sputum, hypoalbuminaemia and erythrocyte sedimentation rate >40 mm/h to be negative prognostic factors for all-cause mortality, and the presence of idiopathic pulmonary fibrosis, haemoglobin <11.3 mg/dL, C reactive protein >1.0 mg/dL and the presence of cavity to be negative prognostic factors for radiographic deterioration.Only 2.4% of patients with NB MAC-LD died from MAC-LD progression.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Saitama, Japan.

No MeSH data available.


Related in: MedlinePlus

Kaplan-Meier survival curves of all-cause mortality of patients with nodular/bronchiectatic Mycobacterium avium complex lung disease with or without bloody sputum. Overall cumulative 5-year and 10-year mortality rates were 12.5% and 27.4%, respectively. Five-year and 10-year all-cause mortality rate in the patients without bloody sputum were 14% and 29%, versus 5.9% and 19.9% in those with bloody sputum (p=0.018), respectively.
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BMJOPEN2015008058F1: Kaplan-Meier survival curves of all-cause mortality of patients with nodular/bronchiectatic Mycobacterium avium complex lung disease with or without bloody sputum. Overall cumulative 5-year and 10-year mortality rates were 12.5% and 27.4%, respectively. Five-year and 10-year all-cause mortality rate in the patients without bloody sputum were 14% and 29%, versus 5.9% and 19.9% in those with bloody sputum (p=0.018), respectively.

Mentions: Respective 5-year and 10-year all-cause mortality rates in the patients without bloody sputum were 14% and 29%, vs 5.9% and 19.9% in those with bloody sputum (p=0.018; figure 1). Since bloody sputum was a risk factor of mortality, we compared baseline characteristics of the patients with and without bloody sputum. As a result, compared with patients without bloody sputum, the patients with bloody sputum were significantly more frequently female (76.4% vs 66.8%, p=0.027), had higher serum albumin (4.1±0.4 vs 4.0±0.5 mg/dL, p=0.026) and lower CRP (0.5±1.1 vs 1.6±3.8 mg/dL, p=0.026) and had less frequently associated pulmonary comorbidity (17.9% vs 29.6%, p=0.002).


Retrospective study of the predictors of mortality and radiographic deterioration in 782 patients with nodular/bronchiectatic Mycobacterium avium complex lung disease.

Gochi M, Takayanagi N, Kanauchi T, Ishiguro T, Yanagisawa T, Sugita Y - BMJ Open (2015)

Kaplan-Meier survival curves of all-cause mortality of patients with nodular/bronchiectatic Mycobacterium avium complex lung disease with or without bloody sputum. Overall cumulative 5-year and 10-year mortality rates were 12.5% and 27.4%, respectively. Five-year and 10-year all-cause mortality rate in the patients without bloody sputum were 14% and 29%, versus 5.9% and 19.9% in those with bloody sputum (p=0.018), respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4538251&req=5

BMJOPEN2015008058F1: Kaplan-Meier survival curves of all-cause mortality of patients with nodular/bronchiectatic Mycobacterium avium complex lung disease with or without bloody sputum. Overall cumulative 5-year and 10-year mortality rates were 12.5% and 27.4%, respectively. Five-year and 10-year all-cause mortality rate in the patients without bloody sputum were 14% and 29%, versus 5.9% and 19.9% in those with bloody sputum (p=0.018), respectively.
Mentions: Respective 5-year and 10-year all-cause mortality rates in the patients without bloody sputum were 14% and 29%, vs 5.9% and 19.9% in those with bloody sputum (p=0.018; figure 1). Since bloody sputum was a risk factor of mortality, we compared baseline characteristics of the patients with and without bloody sputum. As a result, compared with patients without bloody sputum, the patients with bloody sputum were significantly more frequently female (76.4% vs 66.8%, p=0.027), had higher serum albumin (4.1±0.4 vs 4.0±0.5 mg/dL, p=0.026) and lower CRP (0.5±1.1 vs 1.6±3.8 mg/dL, p=0.026) and had less frequently associated pulmonary comorbidity (17.9% vs 29.6%, p=0.002).

Bottom Line: In 536 patients with MAC-LD who were followed-up for more than 1 year, radiographic deterioration occurred in 221 (41.2%) patients and median time-to-radiographic deterioration was 9 years.A multivariate Cox proportional hazard model showed male sex, older age, body mass index <18.5 kg/m(2), absence of bloody sputum, hypoalbuminaemia and erythrocyte sedimentation rate >40 mm/h to be negative prognostic factors for all-cause mortality, and the presence of idiopathic pulmonary fibrosis, haemoglobin <11.3 mg/dL, C reactive protein >1.0 mg/dL and the presence of cavity to be negative prognostic factors for radiographic deterioration.Only 2.4% of patients with NB MAC-LD died from MAC-LD progression.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Saitama, Japan.

No MeSH data available.


Related in: MedlinePlus