Limits...
The Moderating Role of Genetics: The Effect of Length of Hospitalization on Children's Internalizing and Externalizing Behaviors.

Benish-Weisman M, Kerem E, Knafo-Noam A, Belsky J - Front Psychiatry (2015)

Bottom Line: The study considered individual differences in children's ability to adjust to hospitalization and found the length of hospitalization to be related to adaptive psychological functioning for some children.The study found length of hospitalization did not predict emotional and behavior problems per se, but the interaction with genetics was significant; the length of hospitalization was related to diminished levels of internalizing and externalizing problems only for children with the 7R allele (the sensitive variant).The vantage sensitivity model best accounted for how the length of hospitalization and genetics related to children's internalizing and externalizing problems.

View Article: PubMed Central - PubMed

Affiliation: Department of Counseling and Human Development, University of Haifa , Haifa , Israel.

ABSTRACT
The study considered individual differences in children's ability to adjust to hospitalization and found the length of hospitalization to be related to adaptive psychological functioning for some children. Applying the theoretical framework of three competing models of gene-X-environment interactions (diathesis-stress, differential susceptibility, and vantage sensitivity), the study examined the moderating effect of genetics (DRD4) on the relationship between the length of hospitalization and internalizing and externalizing problems. Mothers reported on children's hospitalization background and conduct problems (externalizing) and emotional symptoms (internalizing), using subscales of the 25-item Strength and Difficulties Questionnaire (1). Data on both hospitalization and genetics were available for 65 children, 57% of whom were females, with an average age of 61.4 months (SD = 2.3). The study found length of hospitalization did not predict emotional and behavior problems per se, but the interaction with genetics was significant; the length of hospitalization was related to diminished levels of internalizing and externalizing problems only for children with the 7R allele (the sensitive variant). The vantage sensitivity model best accounted for how the length of hospitalization and genetics related to children's internalizing and externalizing problems.

No MeSH data available.


Related in: MedlinePlus

Interaction effect of length of hospitalization and presence or absence of DRD4-III 7-repeat allele on conduct problems at age five.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4538223&req=5

Figure 2: Interaction effect of length of hospitalization and presence or absence of DRD4-III 7-repeat allele on conduct problems at age five.

Mentions: The model to predict conduct problems at age five fits the data well (CFI = 0.94, RMSEA = 0.06). As we found for emotional symptoms, length of hospitalization did not predict conduct problems at the age of five (β = −0.13, SE = 0.11, Est./S.E. = −1.14, n.s.). Nevertheless, children with 7-present allele had more conduct problems than those with 7-absent allele (β = 4.12, SE = 0.59, Est./S.E. = 6.96, p = 0.00). Furthermore, the interaction between DRD4-III and length of hospitalization was significant in predicting conduct problems among 5-year-olds (β = −4.19, SE = 0.59, Est./S.E. = −7.16, p = 0.00) (see Figure 2); specifically, for the children carrying the 7R-allele, more time in hospital predicted fewer conduct problems.


The Moderating Role of Genetics: The Effect of Length of Hospitalization on Children's Internalizing and Externalizing Behaviors.

Benish-Weisman M, Kerem E, Knafo-Noam A, Belsky J - Front Psychiatry (2015)

Interaction effect of length of hospitalization and presence or absence of DRD4-III 7-repeat allele on conduct problems at age five.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4538223&req=5

Figure 2: Interaction effect of length of hospitalization and presence or absence of DRD4-III 7-repeat allele on conduct problems at age five.
Mentions: The model to predict conduct problems at age five fits the data well (CFI = 0.94, RMSEA = 0.06). As we found for emotional symptoms, length of hospitalization did not predict conduct problems at the age of five (β = −0.13, SE = 0.11, Est./S.E. = −1.14, n.s.). Nevertheless, children with 7-present allele had more conduct problems than those with 7-absent allele (β = 4.12, SE = 0.59, Est./S.E. = 6.96, p = 0.00). Furthermore, the interaction between DRD4-III and length of hospitalization was significant in predicting conduct problems among 5-year-olds (β = −4.19, SE = 0.59, Est./S.E. = −7.16, p = 0.00) (see Figure 2); specifically, for the children carrying the 7R-allele, more time in hospital predicted fewer conduct problems.

Bottom Line: The study considered individual differences in children's ability to adjust to hospitalization and found the length of hospitalization to be related to adaptive psychological functioning for some children.The study found length of hospitalization did not predict emotional and behavior problems per se, but the interaction with genetics was significant; the length of hospitalization was related to diminished levels of internalizing and externalizing problems only for children with the 7R allele (the sensitive variant).The vantage sensitivity model best accounted for how the length of hospitalization and genetics related to children's internalizing and externalizing problems.

View Article: PubMed Central - PubMed

Affiliation: Department of Counseling and Human Development, University of Haifa , Haifa , Israel.

ABSTRACT
The study considered individual differences in children's ability to adjust to hospitalization and found the length of hospitalization to be related to adaptive psychological functioning for some children. Applying the theoretical framework of three competing models of gene-X-environment interactions (diathesis-stress, differential susceptibility, and vantage sensitivity), the study examined the moderating effect of genetics (DRD4) on the relationship between the length of hospitalization and internalizing and externalizing problems. Mothers reported on children's hospitalization background and conduct problems (externalizing) and emotional symptoms (internalizing), using subscales of the 25-item Strength and Difficulties Questionnaire (1). Data on both hospitalization and genetics were available for 65 children, 57% of whom were females, with an average age of 61.4 months (SD = 2.3). The study found length of hospitalization did not predict emotional and behavior problems per se, but the interaction with genetics was significant; the length of hospitalization was related to diminished levels of internalizing and externalizing problems only for children with the 7R allele (the sensitive variant). The vantage sensitivity model best accounted for how the length of hospitalization and genetics related to children's internalizing and externalizing problems.

No MeSH data available.


Related in: MedlinePlus