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The brain-derived neurotrophic factor (BDNF) val66met polymorphism differentially affects performance on subscales of the Wechsler Memory Scale - Third Edition (WMS-III).

Lamb YN, Thompson CS, McKay NS, Waldie KE, Kirk IJ - Front Psychol (2015)

Bottom Line: COMT genotype did not affect performance on either task.Combining subscale scores in memory tests such as the WMS might obscure gene effects.Our results demonstrate the importance of distinguishing between recall and familiarity-based recognition in neurogenetics research.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology, Faculty of Science, The University of Auckland, Auckland New Zealand.

ABSTRACT
Single nucleotide polymorphisms in the brain-derived neurotrophic factor (BDNF) gene and the catechol-O-methyltransferase (COMT) gene influence brain structure and function, as well as cognitive abilities. They are most influential in the hippocampus and prefrontal cortex (PFC), respectively. Recall and recognition are forms of memory proposed to have different neural substrates, with recall having a greater dependence on the PFC and hippocampus. This study aimed to determine whether the BDNF val(66)met or COMT val(158)met polymorphisms differentially affect recall and recognition, and whether these polymorphisms interact. A sample of 100 healthy adults was assessed on recall and familiarity-based recognition using the Faces and Family Pictures subscales of the Wechsler Memory Scale - Third Edition (WMS-III). COMT genotype did not affect performance on either task. The BDNF polymorphism (i.e., met carriers relative to val homozygotes) was associated with poorer recall ability, while not influencing recognition. Combining subscale scores in memory tests such as the WMS might obscure gene effects. Our results demonstrate the importance of distinguishing between recall and familiarity-based recognition in neurogenetics research.

No MeSH data available.


Related in: MedlinePlus

Recall and recognition scores for participants with the brain-derived neurotrophic factor (BDNF) val/val genotype and participants with at least one copy of the BDNF met allele. The error bars are based on ±1 SE. *p < 0.05.
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Figure 1: Recall and recognition scores for participants with the brain-derived neurotrophic factor (BDNF) val/val genotype and participants with at least one copy of the BDNF met allele. The error bars are based on ±1 SE. *p < 0.05.

Mentions: Results of the MANOVA are shown in Table 2. The MANOVA revealed a significant main effect of BDNF genotype on recall performance [F(1,96) = 6.204, p = 0.014]. This main effect is shown in Figure 1. On average, BDNF val homozygotes (M = 79.3, SE = 2.10) attained significantly higher recall scores than met allele carriers (M = 72.0, SE = 2.06).


The brain-derived neurotrophic factor (BDNF) val66met polymorphism differentially affects performance on subscales of the Wechsler Memory Scale - Third Edition (WMS-III).

Lamb YN, Thompson CS, McKay NS, Waldie KE, Kirk IJ - Front Psychol (2015)

Recall and recognition scores for participants with the brain-derived neurotrophic factor (BDNF) val/val genotype and participants with at least one copy of the BDNF met allele. The error bars are based on ±1 SE. *p < 0.05.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4538220&req=5

Figure 1: Recall and recognition scores for participants with the brain-derived neurotrophic factor (BDNF) val/val genotype and participants with at least one copy of the BDNF met allele. The error bars are based on ±1 SE. *p < 0.05.
Mentions: Results of the MANOVA are shown in Table 2. The MANOVA revealed a significant main effect of BDNF genotype on recall performance [F(1,96) = 6.204, p = 0.014]. This main effect is shown in Figure 1. On average, BDNF val homozygotes (M = 79.3, SE = 2.10) attained significantly higher recall scores than met allele carriers (M = 72.0, SE = 2.06).

Bottom Line: COMT genotype did not affect performance on either task.Combining subscale scores in memory tests such as the WMS might obscure gene effects.Our results demonstrate the importance of distinguishing between recall and familiarity-based recognition in neurogenetics research.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology, Faculty of Science, The University of Auckland, Auckland New Zealand.

ABSTRACT
Single nucleotide polymorphisms in the brain-derived neurotrophic factor (BDNF) gene and the catechol-O-methyltransferase (COMT) gene influence brain structure and function, as well as cognitive abilities. They are most influential in the hippocampus and prefrontal cortex (PFC), respectively. Recall and recognition are forms of memory proposed to have different neural substrates, with recall having a greater dependence on the PFC and hippocampus. This study aimed to determine whether the BDNF val(66)met or COMT val(158)met polymorphisms differentially affect recall and recognition, and whether these polymorphisms interact. A sample of 100 healthy adults was assessed on recall and familiarity-based recognition using the Faces and Family Pictures subscales of the Wechsler Memory Scale - Third Edition (WMS-III). COMT genotype did not affect performance on either task. The BDNF polymorphism (i.e., met carriers relative to val homozygotes) was associated with poorer recall ability, while not influencing recognition. Combining subscale scores in memory tests such as the WMS might obscure gene effects. Our results demonstrate the importance of distinguishing between recall and familiarity-based recognition in neurogenetics research.

No MeSH data available.


Related in: MedlinePlus