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A database of virtual healthy subjects to assess the accuracy of foot-to-foot pulse wave velocities for estimation of aortic stiffness.

Willemet M, Chowienczyk P, Alastruey J - Am. J. Physiol. Heart Circ. Physiol. (2015)

Bottom Line: Our numerical results confirm clinical observations: 1) carotid-femoral PWV is a good indicator of aortic stiffness and correlates well with aortic PWV; 2) brachial-ankle PWV overestimates aortic PWV and is related to the stiffness and geometry of both elastic and muscular arteries; and 3) muscular PWV (carotid-radial, femoral-ankle) does not capture the stiffening of the aorta and should therefore not be used as a surrogate for aortic stiffness.In addition, our analysis highlights that the foot-to-foot PWV algorithm is sensitive to the presence of reflected waves in late diastole, which introduce errors in the PWV estimates.In this study, we have created a database of virtual healthy subjects, which can be used to assess theoretically the efficiency of physiological indexes based on pulse wave analysis.

View Article: PubMed Central - PubMed

Affiliation: Division of Imaging Sciences and Biomedical Engineering, St. Thomas' Hospital, King's College London, London, United Kingdom; and marie.willemet@gmail.com.

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Comparison between foot-to-foot PWV and aortic PWV (aPWV; left) and corresponding Bland-Altman plots (right). Each dot represents one virtual subject from the 3,320 physiological cases of our database. cfPWV for the 6 levels of cel considered (A and B), crPWV for the 24 levels of Eel considered (C and D), and faPWV for the 12 levels of Emusc considered (E and F). In Bland-Altman plots, the continuous line indicates the mean value, and dashed lines indicate mean ± 1.96 SD. In A, the dashed line indicates identity.
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Figure 9: Comparison between foot-to-foot PWV and aortic PWV (aPWV; left) and corresponding Bland-Altman plots (right). Each dot represents one virtual subject from the 3,320 physiological cases of our database. cfPWV for the 6 levels of cel considered (A and B), crPWV for the 24 levels of Eel considered (C and D), and faPWV for the 12 levels of Emusc considered (E and F). In Bland-Altman plots, the continuous line indicates the mean value, and dashed lines indicate mean ± 1.96 SD. In A, the dashed line indicates identity.

Mentions: This section compares central and peripheral foot-to-foot PWV indexes. We focus on 1) how central and peripheral PWV indexes are related to aortic PWV (Fig. 9), and 2) on correlations often used in the clinic, involving cfPWV, baPWV, and faPWV (Fig. 10).


A database of virtual healthy subjects to assess the accuracy of foot-to-foot pulse wave velocities for estimation of aortic stiffness.

Willemet M, Chowienczyk P, Alastruey J - Am. J. Physiol. Heart Circ. Physiol. (2015)

Comparison between foot-to-foot PWV and aortic PWV (aPWV; left) and corresponding Bland-Altman plots (right). Each dot represents one virtual subject from the 3,320 physiological cases of our database. cfPWV for the 6 levels of cel considered (A and B), crPWV for the 24 levels of Eel considered (C and D), and faPWV for the 12 levels of Emusc considered (E and F). In Bland-Altman plots, the continuous line indicates the mean value, and dashed lines indicate mean ± 1.96 SD. In A, the dashed line indicates identity.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4537944&req=5

Figure 9: Comparison between foot-to-foot PWV and aortic PWV (aPWV; left) and corresponding Bland-Altman plots (right). Each dot represents one virtual subject from the 3,320 physiological cases of our database. cfPWV for the 6 levels of cel considered (A and B), crPWV for the 24 levels of Eel considered (C and D), and faPWV for the 12 levels of Emusc considered (E and F). In Bland-Altman plots, the continuous line indicates the mean value, and dashed lines indicate mean ± 1.96 SD. In A, the dashed line indicates identity.
Mentions: This section compares central and peripheral foot-to-foot PWV indexes. We focus on 1) how central and peripheral PWV indexes are related to aortic PWV (Fig. 9), and 2) on correlations often used in the clinic, involving cfPWV, baPWV, and faPWV (Fig. 10).

Bottom Line: Our numerical results confirm clinical observations: 1) carotid-femoral PWV is a good indicator of aortic stiffness and correlates well with aortic PWV; 2) brachial-ankle PWV overestimates aortic PWV and is related to the stiffness and geometry of both elastic and muscular arteries; and 3) muscular PWV (carotid-radial, femoral-ankle) does not capture the stiffening of the aorta and should therefore not be used as a surrogate for aortic stiffness.In addition, our analysis highlights that the foot-to-foot PWV algorithm is sensitive to the presence of reflected waves in late diastole, which introduce errors in the PWV estimates.In this study, we have created a database of virtual healthy subjects, which can be used to assess theoretically the efficiency of physiological indexes based on pulse wave analysis.

View Article: PubMed Central - PubMed

Affiliation: Division of Imaging Sciences and Biomedical Engineering, St. Thomas' Hospital, King's College London, London, United Kingdom; and marie.willemet@gmail.com.

Show MeSH
Related in: MedlinePlus