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A database of virtual healthy subjects to assess the accuracy of foot-to-foot pulse wave velocities for estimation of aortic stiffness.

Willemet M, Chowienczyk P, Alastruey J - Am. J. Physiol. Heart Circ. Physiol. (2015)

Bottom Line: For each virtual subject, foot-to-foot PWV was computed from numerical pressure waveforms at the same locations where clinical measurements are commonly taken.Our numerical results confirm clinical observations: 1) carotid-femoral PWV is a good indicator of aortic stiffness and correlates well with aortic PWV; 2) brachial-ankle PWV overestimates aortic PWV and is related to the stiffness and geometry of both elastic and muscular arteries; and 3) muscular PWV (carotid-radial, femoral-ankle) does not capture the stiffening of the aorta and should therefore not be used as a surrogate for aortic stiffness.In addition, our analysis highlights that the foot-to-foot PWV algorithm is sensitive to the presence of reflected waves in late diastole, which introduce errors in the PWV estimates.

View Article: PubMed Central - PubMed

Affiliation: Division of Imaging Sciences and Biomedical Engineering, St. Thomas' Hospital, King's College London, London, United Kingdom; and marie.willemet@gmail.com.

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Averaged relative sensitivity indexes Īi,k of the 5 central and peripheral foot-to-foot PWV (PWVff), as a function of the 7 input parameters indicated in the legend. Error bars represent the SD relative to each parameter around its output.
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Figure 8: Averaged relative sensitivity indexes Īi,k of the 5 central and peripheral foot-to-foot PWV (PWVff), as a function of the 7 input parameters indicated in the legend. Error bars represent the SD relative to each parameter around its output.

Mentions: The deviation of foot-to-foot PWV from theoretical PWV can also be observed in the sensitivity analysis of PWVff to the seven varying parameters (Fig. 8). Unlike the sensitivity analysis of theoretical PWV (Fig. 5), the influence of the diameter of muscular arteries is much larger for central PWV. We also observe a high dispersion of the sensitivity indexes around the mean value, as shown by the considerable standard deviations of average indexes Īi,k.


A database of virtual healthy subjects to assess the accuracy of foot-to-foot pulse wave velocities for estimation of aortic stiffness.

Willemet M, Chowienczyk P, Alastruey J - Am. J. Physiol. Heart Circ. Physiol. (2015)

Averaged relative sensitivity indexes Īi,k of the 5 central and peripheral foot-to-foot PWV (PWVff), as a function of the 7 input parameters indicated in the legend. Error bars represent the SD relative to each parameter around its output.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4537944&req=5

Figure 8: Averaged relative sensitivity indexes Īi,k of the 5 central and peripheral foot-to-foot PWV (PWVff), as a function of the 7 input parameters indicated in the legend. Error bars represent the SD relative to each parameter around its output.
Mentions: The deviation of foot-to-foot PWV from theoretical PWV can also be observed in the sensitivity analysis of PWVff to the seven varying parameters (Fig. 8). Unlike the sensitivity analysis of theoretical PWV (Fig. 5), the influence of the diameter of muscular arteries is much larger for central PWV. We also observe a high dispersion of the sensitivity indexes around the mean value, as shown by the considerable standard deviations of average indexes Īi,k.

Bottom Line: For each virtual subject, foot-to-foot PWV was computed from numerical pressure waveforms at the same locations where clinical measurements are commonly taken.Our numerical results confirm clinical observations: 1) carotid-femoral PWV is a good indicator of aortic stiffness and correlates well with aortic PWV; 2) brachial-ankle PWV overestimates aortic PWV and is related to the stiffness and geometry of both elastic and muscular arteries; and 3) muscular PWV (carotid-radial, femoral-ankle) does not capture the stiffening of the aorta and should therefore not be used as a surrogate for aortic stiffness.In addition, our analysis highlights that the foot-to-foot PWV algorithm is sensitive to the presence of reflected waves in late diastole, which introduce errors in the PWV estimates.

View Article: PubMed Central - PubMed

Affiliation: Division of Imaging Sciences and Biomedical Engineering, St. Thomas' Hospital, King's College London, London, United Kingdom; and marie.willemet@gmail.com.

Show MeSH
Related in: MedlinePlus