Limits...
A database of virtual healthy subjects to assess the accuracy of foot-to-foot pulse wave velocities for estimation of aortic stiffness.

Willemet M, Chowienczyk P, Alastruey J - Am. J. Physiol. Heart Circ. Physiol. (2015)

Bottom Line: Our numerical results confirm clinical observations: 1) carotid-femoral PWV is a good indicator of aortic stiffness and correlates well with aortic PWV; 2) brachial-ankle PWV overestimates aortic PWV and is related to the stiffness and geometry of both elastic and muscular arteries; and 3) muscular PWV (carotid-radial, femoral-ankle) does not capture the stiffening of the aorta and should therefore not be used as a surrogate for aortic stiffness.In addition, our analysis highlights that the foot-to-foot PWV algorithm is sensitive to the presence of reflected waves in late diastole, which introduce errors in the PWV estimates.In this study, we have created a database of virtual healthy subjects, which can be used to assess theoretically the efficiency of physiological indexes based on pulse wave analysis.

View Article: PubMed Central - PubMed

Affiliation: Division of Imaging Sciences and Biomedical Engineering, St. Thomas' Hospital, King's College London, London, United Kingdom; and marie.willemet@gmail.com.

Show MeSH

Related in: MedlinePlus

Theoretical PWV (aPWVth) vs. foot-to-foot PWV (aPWVff) along the aorta (left) and corresponding Bland-Altman plot (right). Each dot represents one of the 3,320 virtual subjects. Gray levels indicate the variation from baseline of the prescribed elastic arteries PWV (cel): from −20% (light gray) to +125% (black). Left: the dashed line indicates identity. Right: the continuous line indicates the mean value and the dashed lines indicate mean ± 1.96 SD.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4537944&req=5

Figure 6: Theoretical PWV (aPWVth) vs. foot-to-foot PWV (aPWVff) along the aorta (left) and corresponding Bland-Altman plot (right). Each dot represents one of the 3,320 virtual subjects. Gray levels indicate the variation from baseline of the prescribed elastic arteries PWV (cel): from −20% (light gray) to +125% (black). Left: the dashed line indicates identity. Right: the continuous line indicates the mean value and the dashed lines indicate mean ± 1.96 SD.

Mentions: Figure 6 compares the foot-to-foot (aPWVff) and the theoretical (aPWVth) pulse wave velocities along the aorta. Both aPWVth and aPWVff vary from 4.2 to 14.3 m/s. aPWVff correlates well with aPWVth (r = 0.946), although aPWVff tends to underestimate aPWVth on average (difference: 0.38 ± 0.87 m/s). This deviation increases with higher elastic artery stiffness, as shown by the Bland-Altman analysis (Fig. 6, right).


A database of virtual healthy subjects to assess the accuracy of foot-to-foot pulse wave velocities for estimation of aortic stiffness.

Willemet M, Chowienczyk P, Alastruey J - Am. J. Physiol. Heart Circ. Physiol. (2015)

Theoretical PWV (aPWVth) vs. foot-to-foot PWV (aPWVff) along the aorta (left) and corresponding Bland-Altman plot (right). Each dot represents one of the 3,320 virtual subjects. Gray levels indicate the variation from baseline of the prescribed elastic arteries PWV (cel): from −20% (light gray) to +125% (black). Left: the dashed line indicates identity. Right: the continuous line indicates the mean value and the dashed lines indicate mean ± 1.96 SD.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4537944&req=5

Figure 6: Theoretical PWV (aPWVth) vs. foot-to-foot PWV (aPWVff) along the aorta (left) and corresponding Bland-Altman plot (right). Each dot represents one of the 3,320 virtual subjects. Gray levels indicate the variation from baseline of the prescribed elastic arteries PWV (cel): from −20% (light gray) to +125% (black). Left: the dashed line indicates identity. Right: the continuous line indicates the mean value and the dashed lines indicate mean ± 1.96 SD.
Mentions: Figure 6 compares the foot-to-foot (aPWVff) and the theoretical (aPWVth) pulse wave velocities along the aorta. Both aPWVth and aPWVff vary from 4.2 to 14.3 m/s. aPWVff correlates well with aPWVth (r = 0.946), although aPWVff tends to underestimate aPWVth on average (difference: 0.38 ± 0.87 m/s). This deviation increases with higher elastic artery stiffness, as shown by the Bland-Altman analysis (Fig. 6, right).

Bottom Line: Our numerical results confirm clinical observations: 1) carotid-femoral PWV is a good indicator of aortic stiffness and correlates well with aortic PWV; 2) brachial-ankle PWV overestimates aortic PWV and is related to the stiffness and geometry of both elastic and muscular arteries; and 3) muscular PWV (carotid-radial, femoral-ankle) does not capture the stiffening of the aorta and should therefore not be used as a surrogate for aortic stiffness.In addition, our analysis highlights that the foot-to-foot PWV algorithm is sensitive to the presence of reflected waves in late diastole, which introduce errors in the PWV estimates.In this study, we have created a database of virtual healthy subjects, which can be used to assess theoretically the efficiency of physiological indexes based on pulse wave analysis.

View Article: PubMed Central - PubMed

Affiliation: Division of Imaging Sciences and Biomedical Engineering, St. Thomas' Hospital, King's College London, London, United Kingdom; and marie.willemet@gmail.com.

Show MeSH
Related in: MedlinePlus