A database of virtual healthy subjects to assess the accuracy of foot-to-foot pulse wave velocities for estimation of aortic stiffness.
Bottom Line: For each virtual subject, foot-to-foot PWV was computed from numerical pressure waveforms at the same locations where clinical measurements are commonly taken.Our numerical results confirm clinical observations: 1) carotid-femoral PWV is a good indicator of aortic stiffness and correlates well with aortic PWV; 2) brachial-ankle PWV overestimates aortic PWV and is related to the stiffness and geometry of both elastic and muscular arteries; and 3) muscular PWV (carotid-radial, femoral-ankle) does not capture the stiffening of the aorta and should therefore not be used as a surrogate for aortic stiffness.In addition, our analysis highlights that the foot-to-foot PWV algorithm is sensitive to the presence of reflected waves in late diastole, which introduce errors in the PWV estimates.
Affiliation: Division of Imaging Sciences and Biomedical Engineering, St. Thomas' Hospital, King's College London, London, United Kingdom; and firstname.lastname@example.org.Show MeSH
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Mentions: There is a substantial change in the shape of pulse waveforms among the 3,325 virtual subjects. Figure 4 shows the individual effect of each varying parameter listed in Table 1 on the brachial pressure and flow waves around the model baseline. For pressure, increasing PWV or decreasing diameters amplifies the waveform, while decreasing HR or increasing SV or R shifts the pressure waveform up (Fig. 4, left). For the flow, muscular arterial parameters have opposite effects to elastic arterial parameters: decreasing muscular PWV or increasing muscular diameters amplifies the flow waveform, while increasing elastic PWV or decreasing elastic diameters has the same effect. Increasing SV amplifies the systolic flow waveform, while changing HR or R does not affect the flow (Fig. 4, right). Similar results were observed elsewhere in the arterial network.
Affiliation: Division of Imaging Sciences and Biomedical Engineering, St. Thomas' Hospital, King's College London, London, United Kingdom; and email@example.com.