A database of virtual healthy subjects to assess the accuracy of foot-to-foot pulse wave velocities for estimation of aortic stiffness.
Bottom Line: For each virtual subject, foot-to-foot PWV was computed from numerical pressure waveforms at the same locations where clinical measurements are commonly taken.Our numerical results confirm clinical observations: 1) carotid-femoral PWV is a good indicator of aortic stiffness and correlates well with aortic PWV; 2) brachial-ankle PWV overestimates aortic PWV and is related to the stiffness and geometry of both elastic and muscular arteries; and 3) muscular PWV (carotid-radial, femoral-ankle) does not capture the stiffening of the aorta and should therefore not be used as a surrogate for aortic stiffness.In addition, our analysis highlights that the foot-to-foot PWV algorithm is sensitive to the presence of reflected waves in late diastole, which introduce errors in the PWV estimates.
Affiliation: Division of Imaging Sciences and Biomedical Engineering, St. Thomas' Hospital, King's College London, London, United Kingdom; and email@example.com.Show MeSH
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Mentions: Blood pressures of all virtual subjects present physiological values with well-balanced distributions (Fig. 2). Cardiac outputs vary between 3.5 and 7.2 l/min, depending on the values of HR (53, 63, and 72 beats/min) and SV (66, 83, and 100 ml) prescribed. Figure 3 shows the distribution of central and peripheral foot-to-foot PWV. Central PWV (aPWV and cfPWV) have similar distributions with a median value ∼7.5 m/s, while peripheral PWV increase to higher distinct levels [median PWV at 10.8 m/s (baPWV), 13.1 m/s (faPWV) and 9.1 m/s (crPWV)]. Dispersions of PWV from the 25th to the 75th percentiles range from 2.5 to 3.5 m/s for all PWV, except for the faPWV (4.5 m/s). All PWV present normal distributions within physiological values, as observed in epidemiological studies of healthy subjects (19, 31, 47).
Affiliation: Division of Imaging Sciences and Biomedical Engineering, St. Thomas' Hospital, King's College London, London, United Kingdom; and firstname.lastname@example.org.