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Cell Therapy in Patients with Critical Limb Ischemia.

Compagna R, Amato B, Massa S, Amato M, Grande R, Butrico L, de Franciscis S, Serra R - Stem Cells Int (2015)

Bottom Line: Recent therapeutic strategies have focused on restoring this balance in favor of tissue survival using exogenous molecular and cellular agents to promote regeneration of the vasculature.This review article carries out a systematic analysis of the most recent scientific literature on the application of stem cells in patients with CLI.The results obtained from the detailed analysis of the recent literature data have confirmed the beneficial role of cell therapy in reducing the rate of major amputations in patients with CLI and improving their quality of life.

View Article: PubMed Central - PubMed

Affiliation: Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Headquarters, University Magna Graecia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy ; Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80100 Naples, Italy.

ABSTRACT
Critical limb ischemia (CLI) represents the most advanced stage of peripheral arterial obstructive disease (PAOD) with a severe obstruction of the arteries which markedly reduces blood flow to the extremities and has progressed to the point of severe rest pain and/or even tissue loss. Recent therapeutic strategies have focused on restoring this balance in favor of tissue survival using exogenous molecular and cellular agents to promote regeneration of the vasculature. These are based on stimulation of angiogenesis by extracellular and cellular components. This review article carries out a systematic analysis of the most recent scientific literature on the application of stem cells in patients with CLI. The results obtained from the detailed analysis of the recent literature data have confirmed the beneficial role of cell therapy in reducing the rate of major amputations in patients with CLI and improving their quality of life.

No MeSH data available.


Related in: MedlinePlus

Flow of papers identified from search strategy.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4537766&req=5

fig1: Flow of papers identified from search strategy.

Mentions: Study Selection. The initial database searches yielded 68587 studies from PubMed, 526 from ScienceDirect, and 1 from Scopus in the last 5 years. We evaluated 1031 eligible full text articles (Figure 1).


Cell Therapy in Patients with Critical Limb Ischemia.

Compagna R, Amato B, Massa S, Amato M, Grande R, Butrico L, de Franciscis S, Serra R - Stem Cells Int (2015)

Flow of papers identified from search strategy.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4537766&req=5

fig1: Flow of papers identified from search strategy.
Mentions: Study Selection. The initial database searches yielded 68587 studies from PubMed, 526 from ScienceDirect, and 1 from Scopus in the last 5 years. We evaluated 1031 eligible full text articles (Figure 1).

Bottom Line: Recent therapeutic strategies have focused on restoring this balance in favor of tissue survival using exogenous molecular and cellular agents to promote regeneration of the vasculature.This review article carries out a systematic analysis of the most recent scientific literature on the application of stem cells in patients with CLI.The results obtained from the detailed analysis of the recent literature data have confirmed the beneficial role of cell therapy in reducing the rate of major amputations in patients with CLI and improving their quality of life.

View Article: PubMed Central - PubMed

Affiliation: Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Headquarters, University Magna Graecia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy ; Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80100 Naples, Italy.

ABSTRACT
Critical limb ischemia (CLI) represents the most advanced stage of peripheral arterial obstructive disease (PAOD) with a severe obstruction of the arteries which markedly reduces blood flow to the extremities and has progressed to the point of severe rest pain and/or even tissue loss. Recent therapeutic strategies have focused on restoring this balance in favor of tissue survival using exogenous molecular and cellular agents to promote regeneration of the vasculature. These are based on stimulation of angiogenesis by extracellular and cellular components. This review article carries out a systematic analysis of the most recent scientific literature on the application of stem cells in patients with CLI. The results obtained from the detailed analysis of the recent literature data have confirmed the beneficial role of cell therapy in reducing the rate of major amputations in patients with CLI and improving their quality of life.

No MeSH data available.


Related in: MedlinePlus