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Spectral-Domain Optical Coherence Tomography of Preclinical Chloroquine Maculopathy in Egyptian Rheumatoid Arthritis Patients.

Allam RS, Abd-Elmohsen MN, Khafagy MM, Raafat KA, Sheta SM - J Ophthalmol (2015)

Bottom Line: The mean CFT was found to be thinner in the Chloroquine group (238.15 µm ± 22.49) than the normal controls (248.2 µm ± 19.04), which was statistically significant (p value = 0.034).No significant difference was detected between the two groups regarding RNFL, GCC, or IS/OS junction.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Ophthalmology Department, Kasr Al-Ainy School of Medicine, Cairo University, Cairo 11559, Egypt.

ABSTRACT
Purpose. To evaluate the role of spectral-domain optical coherence tomography (SD-OCT) in early detection of Chloroquine maculopathy in rheumatoid arthritis (RA) patients. Methods. 40 left eyes of 40 female rheumatoid arthritis patients who received treatment chloroquine for more than one year were recruited in the study. All patients had no symptoms or signs of Chloroquine retinopathy. They were evaluated using SD-OCT, where the Central Foveal Thickness (CFT), parafoveal thickness and perifoveal thickness, average Retinal Nerve Fiber Layer (RNFL) thickness, and Ganglion Cell Complex (GCC) measurements were measured and compared to 40 left eyes of 40 normal females. Results. The mean CFT was found to be thinner in the Chloroquine group (238.15 µm ± 22.49) than the normal controls (248.2 µm ± 19.04), which was statistically significant (p value = 0.034). The mean parafoveal thickness was lesser in the Chloroquine group than the control group in all quadrants (p value <0.05). The perifoveal thickness in both groups showed no statistically significant difference (p value >0.05) in all quadrants. No significant difference was detected between the two groups regarding RNFL, GCC, or IS/OS junction. Conclusions. Preclinical Chloroquine toxicity can lead to early thinning in the central fovea as well as the parafoveal regions that is detected by SD-OCT.

No MeSH data available.


Related in: MedlinePlus

IS/OS interrupted in a patient from the Chloroquine group.
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fig2: IS/OS interrupted in a patient from the Chloroquine group.

Mentions: IS/OS junction showed an interruption in 2 patients from the control group and 4 patients from the Chloroquine group (Figure 2). This was statistically not significant (p value 0.675, Fisher's exact test).


Spectral-Domain Optical Coherence Tomography of Preclinical Chloroquine Maculopathy in Egyptian Rheumatoid Arthritis Patients.

Allam RS, Abd-Elmohsen MN, Khafagy MM, Raafat KA, Sheta SM - J Ophthalmol (2015)

IS/OS interrupted in a patient from the Chloroquine group.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4537754&req=5

fig2: IS/OS interrupted in a patient from the Chloroquine group.
Mentions: IS/OS junction showed an interruption in 2 patients from the control group and 4 patients from the Chloroquine group (Figure 2). This was statistically not significant (p value 0.675, Fisher's exact test).

Bottom Line: The mean CFT was found to be thinner in the Chloroquine group (238.15 µm ± 22.49) than the normal controls (248.2 µm ± 19.04), which was statistically significant (p value = 0.034).No significant difference was detected between the two groups regarding RNFL, GCC, or IS/OS junction.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Ophthalmology Department, Kasr Al-Ainy School of Medicine, Cairo University, Cairo 11559, Egypt.

ABSTRACT
Purpose. To evaluate the role of spectral-domain optical coherence tomography (SD-OCT) in early detection of Chloroquine maculopathy in rheumatoid arthritis (RA) patients. Methods. 40 left eyes of 40 female rheumatoid arthritis patients who received treatment chloroquine for more than one year were recruited in the study. All patients had no symptoms or signs of Chloroquine retinopathy. They were evaluated using SD-OCT, where the Central Foveal Thickness (CFT), parafoveal thickness and perifoveal thickness, average Retinal Nerve Fiber Layer (RNFL) thickness, and Ganglion Cell Complex (GCC) measurements were measured and compared to 40 left eyes of 40 normal females. Results. The mean CFT was found to be thinner in the Chloroquine group (238.15 µm ± 22.49) than the normal controls (248.2 µm ± 19.04), which was statistically significant (p value = 0.034). The mean parafoveal thickness was lesser in the Chloroquine group than the control group in all quadrants (p value <0.05). The perifoveal thickness in both groups showed no statistically significant difference (p value >0.05) in all quadrants. No significant difference was detected between the two groups regarding RNFL, GCC, or IS/OS junction. Conclusions. Preclinical Chloroquine toxicity can lead to early thinning in the central fovea as well as the parafoveal regions that is detected by SD-OCT.

No MeSH data available.


Related in: MedlinePlus