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Comparative Effect of Lisinopril and Fosinopril in Mitigating Learning and Memory Deficit in Scopolamine-Induced Amnesic Rats.

Deb D, Bairy KL, Nayak V, Rao M - Adv Pharmacol Sci (2015)

Bottom Line: Scopolamine induced marked impairment of memory in behavioral tests which correlated with morphological changes in hippocampus.Pretreatment with fosinopril 1.80 mg/kg was found to significantly ameliorate the memory deficits and hippocampal degeneration induced by scopolamine.Fosinopril exhibits antiamnesic activity, indicating its possible role in preventing memory deficits seen in dementia though the precise mechanism underlying this effect needs to be further evaluated.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Melaka Manipal Medical College, Manipal University, Manipal Campus, Manipal 576104, India.

ABSTRACT
Lisinopril and fosinopril were compared on scopolamine-induced learning and memory deficits in rats. A total of eighty-four male Wistar rats were divided into seven groups. Group I received 2% gum acacia orally for 4 weeks, group II received normal saline, and group III received scopolamine (2 mg/kg/ip) as single dose. Groups IV and V received lisinopril ( 0.225 mg/kg and 0.45 mg/kg), while Groups VI and VII received fosinopril (0.90 mg/kg and 1.80 mg/kg), respectively, orally for four weeks, followed by scopolamine (2 mg/kg/ip) given 45 minutes prior to experimental procedure. Evaluation of learning and memory was assessed by using passive avoidance, Morris water maze, and elevated plus maze tests followed by analysis of hippocampal morphology and quantification of the number of surviving neurons. Scopolamine induced marked impairment of memory in behavioral tests which correlated with morphological changes in hippocampus. Pretreatment with fosinopril 1.80 mg/kg was found to significantly ameliorate the memory deficits and hippocampal degeneration induced by scopolamine. Fosinopril exhibits antiamnesic activity, indicating its possible role in preventing memory deficits seen in dementia though the precise mechanism underlying this effect needs to be further evaluated.

No MeSH data available.


Related in: MedlinePlus

Effect of lisinopril and fosinopril in scopolamine-induced amnesic rats during the acquisition trials in Morris water maze test. Comparison between control, scopolamine, lisinopril, and fosinopril treated groups during the acquisition trials on day 1 and day 4 of Morris water maze test. Values are mean ± SE, ∗versus scopolamine (p < 0.05), ∗∗versus scopolamine (p < 0.001), aversus control (p < 0.05), and bversus control (p < 0.001).
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fig2: Effect of lisinopril and fosinopril in scopolamine-induced amnesic rats during the acquisition trials in Morris water maze test. Comparison between control, scopolamine, lisinopril, and fosinopril treated groups during the acquisition trials on day 1 and day 4 of Morris water maze test. Values are mean ± SE, ∗versus scopolamine (p < 0.05), ∗∗versus scopolamine (p < 0.001), aversus control (p < 0.05), and bversus control (p < 0.001).

Mentions: Control rats which received gum acacia and saline rapidly learned the location of the hidden platform as reflected by a decrease in their latencies from day 1 to day 4, indicating normal acquisition behaviour (Table 4 and Figure 2). Rats which received scopolamine showed an increased latency to locate the hidden platform during the acquisition trials, the difference being statistically significant compared to control rats (p < 0.001). This indicates impairment of acquisition in the scopolamine treated rats. Further, scopolamine treated rats showed a significant increase in the latency to locate the target quadrant (Q4) compared to control rats (p < 0.001), which indicates impaired memory (Table 4 and Figure 2).


Comparative Effect of Lisinopril and Fosinopril in Mitigating Learning and Memory Deficit in Scopolamine-Induced Amnesic Rats.

Deb D, Bairy KL, Nayak V, Rao M - Adv Pharmacol Sci (2015)

Effect of lisinopril and fosinopril in scopolamine-induced amnesic rats during the acquisition trials in Morris water maze test. Comparison between control, scopolamine, lisinopril, and fosinopril treated groups during the acquisition trials on day 1 and day 4 of Morris water maze test. Values are mean ± SE, ∗versus scopolamine (p < 0.05), ∗∗versus scopolamine (p < 0.001), aversus control (p < 0.05), and bversus control (p < 0.001).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4537708&req=5

fig2: Effect of lisinopril and fosinopril in scopolamine-induced amnesic rats during the acquisition trials in Morris water maze test. Comparison between control, scopolamine, lisinopril, and fosinopril treated groups during the acquisition trials on day 1 and day 4 of Morris water maze test. Values are mean ± SE, ∗versus scopolamine (p < 0.05), ∗∗versus scopolamine (p < 0.001), aversus control (p < 0.05), and bversus control (p < 0.001).
Mentions: Control rats which received gum acacia and saline rapidly learned the location of the hidden platform as reflected by a decrease in their latencies from day 1 to day 4, indicating normal acquisition behaviour (Table 4 and Figure 2). Rats which received scopolamine showed an increased latency to locate the hidden platform during the acquisition trials, the difference being statistically significant compared to control rats (p < 0.001). This indicates impairment of acquisition in the scopolamine treated rats. Further, scopolamine treated rats showed a significant increase in the latency to locate the target quadrant (Q4) compared to control rats (p < 0.001), which indicates impaired memory (Table 4 and Figure 2).

Bottom Line: Scopolamine induced marked impairment of memory in behavioral tests which correlated with morphological changes in hippocampus.Pretreatment with fosinopril 1.80 mg/kg was found to significantly ameliorate the memory deficits and hippocampal degeneration induced by scopolamine.Fosinopril exhibits antiamnesic activity, indicating its possible role in preventing memory deficits seen in dementia though the precise mechanism underlying this effect needs to be further evaluated.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Melaka Manipal Medical College, Manipal University, Manipal Campus, Manipal 576104, India.

ABSTRACT
Lisinopril and fosinopril were compared on scopolamine-induced learning and memory deficits in rats. A total of eighty-four male Wistar rats were divided into seven groups. Group I received 2% gum acacia orally for 4 weeks, group II received normal saline, and group III received scopolamine (2 mg/kg/ip) as single dose. Groups IV and V received lisinopril ( 0.225 mg/kg and 0.45 mg/kg), while Groups VI and VII received fosinopril (0.90 mg/kg and 1.80 mg/kg), respectively, orally for four weeks, followed by scopolamine (2 mg/kg/ip) given 45 minutes prior to experimental procedure. Evaluation of learning and memory was assessed by using passive avoidance, Morris water maze, and elevated plus maze tests followed by analysis of hippocampal morphology and quantification of the number of surviving neurons. Scopolamine induced marked impairment of memory in behavioral tests which correlated with morphological changes in hippocampus. Pretreatment with fosinopril 1.80 mg/kg was found to significantly ameliorate the memory deficits and hippocampal degeneration induced by scopolamine. Fosinopril exhibits antiamnesic activity, indicating its possible role in preventing memory deficits seen in dementia though the precise mechanism underlying this effect needs to be further evaluated.

No MeSH data available.


Related in: MedlinePlus