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Comparative Effect of Lisinopril and Fosinopril in Mitigating Learning and Memory Deficit in Scopolamine-Induced Amnesic Rats.

Deb D, Bairy KL, Nayak V, Rao M - Adv Pharmacol Sci (2015)

Bottom Line: Scopolamine induced marked impairment of memory in behavioral tests which correlated with morphological changes in hippocampus.Pretreatment with fosinopril 1.80 mg/kg was found to significantly ameliorate the memory deficits and hippocampal degeneration induced by scopolamine.Fosinopril exhibits antiamnesic activity, indicating its possible role in preventing memory deficits seen in dementia though the precise mechanism underlying this effect needs to be further evaluated.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Melaka Manipal Medical College, Manipal University, Manipal Campus, Manipal 576104, India.

ABSTRACT
Lisinopril and fosinopril were compared on scopolamine-induced learning and memory deficits in rats. A total of eighty-four male Wistar rats were divided into seven groups. Group I received 2% gum acacia orally for 4 weeks, group II received normal saline, and group III received scopolamine (2 mg/kg/ip) as single dose. Groups IV and V received lisinopril ( 0.225 mg/kg and 0.45 mg/kg), while Groups VI and VII received fosinopril (0.90 mg/kg and 1.80 mg/kg), respectively, orally for four weeks, followed by scopolamine (2 mg/kg/ip) given 45 minutes prior to experimental procedure. Evaluation of learning and memory was assessed by using passive avoidance, Morris water maze, and elevated plus maze tests followed by analysis of hippocampal morphology and quantification of the number of surviving neurons. Scopolamine induced marked impairment of memory in behavioral tests which correlated with morphological changes in hippocampus. Pretreatment with fosinopril 1.80 mg/kg was found to significantly ameliorate the memory deficits and hippocampal degeneration induced by scopolamine. Fosinopril exhibits antiamnesic activity, indicating its possible role in preventing memory deficits seen in dementia though the precise mechanism underlying this effect needs to be further evaluated.

No MeSH data available.


Related in: MedlinePlus

Effect of lisinopril and fosinopril in scopolamine-induced amnesic rats during the exploration trials in passive avoidance test. Comparison between control, scopolamine, lisinopril, and fosinopril during the exploration trials in passive avoidance test. Values are mean ± SE, ∗versus scopolamine (p < 0.05), ∗∗versus scopolamine (p < 0.001), aversus control (p < 0.05), and bversus control (p < 0.001).
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Related In: Results  -  Collection


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fig1: Effect of lisinopril and fosinopril in scopolamine-induced amnesic rats during the exploration trials in passive avoidance test. Comparison between control, scopolamine, lisinopril, and fosinopril during the exploration trials in passive avoidance test. Values are mean ± SE, ∗versus scopolamine (p < 0.05), ∗∗versus scopolamine (p < 0.001), aversus control (p < 0.05), and bversus control (p < 0.001).

Mentions: During the exploratory trials, the latency to enter the dark compartment was decreased in all the groups from first to third trial. The scopolamine treated animals took more time to enter the dark compartment during the three exploration trials (Table 2 and Figure 1). Rats pretreated with lower and higher doses of lisinopril did not show significant difference during the exploration trials compared to scopolamine treated rats. Lower dose of fosinopril also could not significantly ameliorate scopolamine-induced learning impairment as reflected in their latency during the exploratory trials (Table 2 and Figure 1). However, rats pretreated with high dose of fosinopril showed a decreased latency to enter the dark compartment during the exploratory trials and spent more time in the light compartment in each successive trial compared to scopolamine treated rats (p < 0.05). This is indicative of positive learning behaviour among fosinopril treated rats.


Comparative Effect of Lisinopril and Fosinopril in Mitigating Learning and Memory Deficit in Scopolamine-Induced Amnesic Rats.

Deb D, Bairy KL, Nayak V, Rao M - Adv Pharmacol Sci (2015)

Effect of lisinopril and fosinopril in scopolamine-induced amnesic rats during the exploration trials in passive avoidance test. Comparison between control, scopolamine, lisinopril, and fosinopril during the exploration trials in passive avoidance test. Values are mean ± SE, ∗versus scopolamine (p < 0.05), ∗∗versus scopolamine (p < 0.001), aversus control (p < 0.05), and bversus control (p < 0.001).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4537708&req=5

fig1: Effect of lisinopril and fosinopril in scopolamine-induced amnesic rats during the exploration trials in passive avoidance test. Comparison between control, scopolamine, lisinopril, and fosinopril during the exploration trials in passive avoidance test. Values are mean ± SE, ∗versus scopolamine (p < 0.05), ∗∗versus scopolamine (p < 0.001), aversus control (p < 0.05), and bversus control (p < 0.001).
Mentions: During the exploratory trials, the latency to enter the dark compartment was decreased in all the groups from first to third trial. The scopolamine treated animals took more time to enter the dark compartment during the three exploration trials (Table 2 and Figure 1). Rats pretreated with lower and higher doses of lisinopril did not show significant difference during the exploration trials compared to scopolamine treated rats. Lower dose of fosinopril also could not significantly ameliorate scopolamine-induced learning impairment as reflected in their latency during the exploratory trials (Table 2 and Figure 1). However, rats pretreated with high dose of fosinopril showed a decreased latency to enter the dark compartment during the exploratory trials and spent more time in the light compartment in each successive trial compared to scopolamine treated rats (p < 0.05). This is indicative of positive learning behaviour among fosinopril treated rats.

Bottom Line: Scopolamine induced marked impairment of memory in behavioral tests which correlated with morphological changes in hippocampus.Pretreatment with fosinopril 1.80 mg/kg was found to significantly ameliorate the memory deficits and hippocampal degeneration induced by scopolamine.Fosinopril exhibits antiamnesic activity, indicating its possible role in preventing memory deficits seen in dementia though the precise mechanism underlying this effect needs to be further evaluated.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Melaka Manipal Medical College, Manipal University, Manipal Campus, Manipal 576104, India.

ABSTRACT
Lisinopril and fosinopril were compared on scopolamine-induced learning and memory deficits in rats. A total of eighty-four male Wistar rats were divided into seven groups. Group I received 2% gum acacia orally for 4 weeks, group II received normal saline, and group III received scopolamine (2 mg/kg/ip) as single dose. Groups IV and V received lisinopril ( 0.225 mg/kg and 0.45 mg/kg), while Groups VI and VII received fosinopril (0.90 mg/kg and 1.80 mg/kg), respectively, orally for four weeks, followed by scopolamine (2 mg/kg/ip) given 45 minutes prior to experimental procedure. Evaluation of learning and memory was assessed by using passive avoidance, Morris water maze, and elevated plus maze tests followed by analysis of hippocampal morphology and quantification of the number of surviving neurons. Scopolamine induced marked impairment of memory in behavioral tests which correlated with morphological changes in hippocampus. Pretreatment with fosinopril 1.80 mg/kg was found to significantly ameliorate the memory deficits and hippocampal degeneration induced by scopolamine. Fosinopril exhibits antiamnesic activity, indicating its possible role in preventing memory deficits seen in dementia though the precise mechanism underlying this effect needs to be further evaluated.

No MeSH data available.


Related in: MedlinePlus