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Intercellular Adhesion Molecule-1 (ICAM-1) Polymorphisms and Cancer Risk: A Meta-Analysis.

Cheng D, Liang B - Iran. J. Public Health (2015)

Bottom Line: However, the results of previous studies are inconsistent.AA) in European subgroup, respectively.The subgroup analysis by ethnicity showed that G241R polymorphism was significantly associated with cancer risk in European subgroup.

View Article: PubMed Central - PubMed

Affiliation: Dept. of Transfusion, The First Hospital of China Medical University, Shenyang, P.R. China.

ABSTRACT

Background: Intercellular adhesion molecule-1 (ICAM-1) Lys469Glu (K469E) polymorphism and Gly 241Arg (G241R) polymorphism might play important roles in cancer development and progression. However, the results of previous studies are inconsistent. The aim of this study was to evaluate the association between ICAM-1 K469E and G241R polymorphisms and the risk of cancer by meta-analysis.

Methods: A comprehensive literature search (last search updated in November 2013) was conducted to identify case-control studies that investigated the association between ICAM-1 K469E and G241R polymorphisms and cancer risk.

Results: A total of 18 case-control studies for ICAM-1 polymorphisms were included in the meta-analysis, including 4,844 cancer cases and 5,618 healthy controls. For K469E polymorphism, no significant association was found between K469E polymorphism and cancer risk. However, subgroup analysis by ethnicity revealed one genetic comparison (GG vs. AA) presented the relationship with cancer risk in Asian subgroup, and two genetic models (GG+GA vs. AA and GA vs. AA) in European subgroup, respectively. For G241R polymorphism, G241R polymorphism was significantly association with cancer risk in overall analysis. The subgroup analysis by ethnicity showed that G241R polymorphism was significantly associated with cancer risk in European subgroup.

Conclusion: ICAM-1 G241R polymorphism might be associated with cancer risk, especially in European populations, but the results doesn't support ICAM-1 K469E polymorphism as a risk factor for cancer.

No MeSH data available.


Related in: MedlinePlus

Begg’s funnel plot for publication bias test. Each point represents an independent study for the indicated association under the allele model. (a) ICAM-1 K469E polymorphism, (b) ICAM-1 G241R polymorphism
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Figure 4: Begg’s funnel plot for publication bias test. Each point represents an independent study for the indicated association under the allele model. (a) ICAM-1 K469E polymorphism, (b) ICAM-1 G241R polymorphism

Mentions: In this meta-analysis, we performed Begg’s funnel plot and Egger’s test to access the publication bias. The shape of the funnel plots did not reveal any evidence of obvious asymmetry under all contrast models for ICAM-1 K469E and G241R (Fig. 4). In addition, the P value of Egger’s test was 0.633 for ICAM-1 K469E polymorphism, and 0.704 for ICAM-1 G241R polymorphism under the allele model, respectively, providing statistical evidence of funnel plot’s symmetry. Therefore, the results revealed that publication bias was not significant in this meta-analysis.


Intercellular Adhesion Molecule-1 (ICAM-1) Polymorphisms and Cancer Risk: A Meta-Analysis.

Cheng D, Liang B - Iran. J. Public Health (2015)

Begg’s funnel plot for publication bias test. Each point represents an independent study for the indicated association under the allele model. (a) ICAM-1 K469E polymorphism, (b) ICAM-1 G241R polymorphism
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4537618&req=5

Figure 4: Begg’s funnel plot for publication bias test. Each point represents an independent study for the indicated association under the allele model. (a) ICAM-1 K469E polymorphism, (b) ICAM-1 G241R polymorphism
Mentions: In this meta-analysis, we performed Begg’s funnel plot and Egger’s test to access the publication bias. The shape of the funnel plots did not reveal any evidence of obvious asymmetry under all contrast models for ICAM-1 K469E and G241R (Fig. 4). In addition, the P value of Egger’s test was 0.633 for ICAM-1 K469E polymorphism, and 0.704 for ICAM-1 G241R polymorphism under the allele model, respectively, providing statistical evidence of funnel plot’s symmetry. Therefore, the results revealed that publication bias was not significant in this meta-analysis.

Bottom Line: However, the results of previous studies are inconsistent.AA) in European subgroup, respectively.The subgroup analysis by ethnicity showed that G241R polymorphism was significantly associated with cancer risk in European subgroup.

View Article: PubMed Central - PubMed

Affiliation: Dept. of Transfusion, The First Hospital of China Medical University, Shenyang, P.R. China.

ABSTRACT

Background: Intercellular adhesion molecule-1 (ICAM-1) Lys469Glu (K469E) polymorphism and Gly 241Arg (G241R) polymorphism might play important roles in cancer development and progression. However, the results of previous studies are inconsistent. The aim of this study was to evaluate the association between ICAM-1 K469E and G241R polymorphisms and the risk of cancer by meta-analysis.

Methods: A comprehensive literature search (last search updated in November 2013) was conducted to identify case-control studies that investigated the association between ICAM-1 K469E and G241R polymorphisms and cancer risk.

Results: A total of 18 case-control studies for ICAM-1 polymorphisms were included in the meta-analysis, including 4,844 cancer cases and 5,618 healthy controls. For K469E polymorphism, no significant association was found between K469E polymorphism and cancer risk. However, subgroup analysis by ethnicity revealed one genetic comparison (GG vs. AA) presented the relationship with cancer risk in Asian subgroup, and two genetic models (GG+GA vs. AA and GA vs. AA) in European subgroup, respectively. For G241R polymorphism, G241R polymorphism was significantly association with cancer risk in overall analysis. The subgroup analysis by ethnicity showed that G241R polymorphism was significantly associated with cancer risk in European subgroup.

Conclusion: ICAM-1 G241R polymorphism might be associated with cancer risk, especially in European populations, but the results doesn't support ICAM-1 K469E polymorphism as a risk factor for cancer.

No MeSH data available.


Related in: MedlinePlus