Limits...
Intercellular Adhesion Molecule-1 (ICAM-1) Polymorphisms and Cancer Risk: A Meta-Analysis.

Cheng D, Liang B - Iran. J. Public Health (2015)

Bottom Line: However, the results of previous studies are inconsistent.AA) in European subgroup, respectively.The subgroup analysis by ethnicity showed that G241R polymorphism was significantly associated with cancer risk in European subgroup.

View Article: PubMed Central - PubMed

Affiliation: Dept. of Transfusion, The First Hospital of China Medical University, Shenyang, P.R. China.

ABSTRACT

Background: Intercellular adhesion molecule-1 (ICAM-1) Lys469Glu (K469E) polymorphism and Gly 241Arg (G241R) polymorphism might play important roles in cancer development and progression. However, the results of previous studies are inconsistent. The aim of this study was to evaluate the association between ICAM-1 K469E and G241R polymorphisms and the risk of cancer by meta-analysis.

Methods: A comprehensive literature search (last search updated in November 2013) was conducted to identify case-control studies that investigated the association between ICAM-1 K469E and G241R polymorphisms and cancer risk.

Results: A total of 18 case-control studies for ICAM-1 polymorphisms were included in the meta-analysis, including 4,844 cancer cases and 5,618 healthy controls. For K469E polymorphism, no significant association was found between K469E polymorphism and cancer risk. However, subgroup analysis by ethnicity revealed one genetic comparison (GG vs. AA) presented the relationship with cancer risk in Asian subgroup, and two genetic models (GG+GA vs. AA and GA vs. AA) in European subgroup, respectively. For G241R polymorphism, G241R polymorphism was significantly association with cancer risk in overall analysis. The subgroup analysis by ethnicity showed that G241R polymorphism was significantly associated with cancer risk in European subgroup.

Conclusion: ICAM-1 G241R polymorphism might be associated with cancer risk, especially in European populations, but the results doesn't support ICAM-1 K469E polymorphism as a risk factor for cancer.

No MeSH data available.


Related in: MedlinePlus

Meta-analysis with a random-effects model for the association between the risk of cancer and ICAM-1 G241R polymorphism (dominant model: AA + AG vs. GG)
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4537618&req=5

Figure 3: Meta-analysis with a random-effects model for the association between the risk of cancer and ICAM-1 G241R polymorphism (dominant model: AA + AG vs. GG)

Mentions: A total of 921 cases and 955 controls from 6 case-control studies on the correlation of ICAM-1 G241R polymorphism and cancer risk were included for data synthesis. In general, the overall analysis revealed ICAM-1 G241R polymorphism seemed to be associated with cancer risk (A allele vs. G allele: OR= 2.21, 95% CI = 1.31–3.74, P<0.01; AA+AG vs. GG: OR = 2.16, 95% CI = 1.37–3.43, P<0.01; AA vs. GG: OR = 2.45, 95% CI = 1.12–5.35, P=0.02; AG vs. GG: OR= 2.03, 95% CI = 1.54–2.67, P<0.01) (Fig. 3).


Intercellular Adhesion Molecule-1 (ICAM-1) Polymorphisms and Cancer Risk: A Meta-Analysis.

Cheng D, Liang B - Iran. J. Public Health (2015)

Meta-analysis with a random-effects model for the association between the risk of cancer and ICAM-1 G241R polymorphism (dominant model: AA + AG vs. GG)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4537618&req=5

Figure 3: Meta-analysis with a random-effects model for the association between the risk of cancer and ICAM-1 G241R polymorphism (dominant model: AA + AG vs. GG)
Mentions: A total of 921 cases and 955 controls from 6 case-control studies on the correlation of ICAM-1 G241R polymorphism and cancer risk were included for data synthesis. In general, the overall analysis revealed ICAM-1 G241R polymorphism seemed to be associated with cancer risk (A allele vs. G allele: OR= 2.21, 95% CI = 1.31–3.74, P<0.01; AA+AG vs. GG: OR = 2.16, 95% CI = 1.37–3.43, P<0.01; AA vs. GG: OR = 2.45, 95% CI = 1.12–5.35, P=0.02; AG vs. GG: OR= 2.03, 95% CI = 1.54–2.67, P<0.01) (Fig. 3).

Bottom Line: However, the results of previous studies are inconsistent.AA) in European subgroup, respectively.The subgroup analysis by ethnicity showed that G241R polymorphism was significantly associated with cancer risk in European subgroup.

View Article: PubMed Central - PubMed

Affiliation: Dept. of Transfusion, The First Hospital of China Medical University, Shenyang, P.R. China.

ABSTRACT

Background: Intercellular adhesion molecule-1 (ICAM-1) Lys469Glu (K469E) polymorphism and Gly 241Arg (G241R) polymorphism might play important roles in cancer development and progression. However, the results of previous studies are inconsistent. The aim of this study was to evaluate the association between ICAM-1 K469E and G241R polymorphisms and the risk of cancer by meta-analysis.

Methods: A comprehensive literature search (last search updated in November 2013) was conducted to identify case-control studies that investigated the association between ICAM-1 K469E and G241R polymorphisms and cancer risk.

Results: A total of 18 case-control studies for ICAM-1 polymorphisms were included in the meta-analysis, including 4,844 cancer cases and 5,618 healthy controls. For K469E polymorphism, no significant association was found between K469E polymorphism and cancer risk. However, subgroup analysis by ethnicity revealed one genetic comparison (GG vs. AA) presented the relationship with cancer risk in Asian subgroup, and two genetic models (GG+GA vs. AA and GA vs. AA) in European subgroup, respectively. For G241R polymorphism, G241R polymorphism was significantly association with cancer risk in overall analysis. The subgroup analysis by ethnicity showed that G241R polymorphism was significantly associated with cancer risk in European subgroup.

Conclusion: ICAM-1 G241R polymorphism might be associated with cancer risk, especially in European populations, but the results doesn't support ICAM-1 K469E polymorphism as a risk factor for cancer.

No MeSH data available.


Related in: MedlinePlus