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Intercellular Adhesion Molecule-1 (ICAM-1) Polymorphisms and Cancer Risk: A Meta-Analysis.

Cheng D, Liang B - Iran. J. Public Health (2015)

Bottom Line: However, the results of previous studies are inconsistent.AA) in European subgroup, respectively.The subgroup analysis by ethnicity showed that G241R polymorphism was significantly associated with cancer risk in European subgroup.

View Article: PubMed Central - PubMed

Affiliation: Dept. of Transfusion, The First Hospital of China Medical University, Shenyang, P.R. China.

ABSTRACT

Background: Intercellular adhesion molecule-1 (ICAM-1) Lys469Glu (K469E) polymorphism and Gly 241Arg (G241R) polymorphism might play important roles in cancer development and progression. However, the results of previous studies are inconsistent. The aim of this study was to evaluate the association between ICAM-1 K469E and G241R polymorphisms and the risk of cancer by meta-analysis.

Methods: A comprehensive literature search (last search updated in November 2013) was conducted to identify case-control studies that investigated the association between ICAM-1 K469E and G241R polymorphisms and cancer risk.

Results: A total of 18 case-control studies for ICAM-1 polymorphisms were included in the meta-analysis, including 4,844 cancer cases and 5,618 healthy controls. For K469E polymorphism, no significant association was found between K469E polymorphism and cancer risk. However, subgroup analysis by ethnicity revealed one genetic comparison (GG vs. AA) presented the relationship with cancer risk in Asian subgroup, and two genetic models (GG+GA vs. AA and GA vs. AA) in European subgroup, respectively. For G241R polymorphism, G241R polymorphism was significantly association with cancer risk in overall analysis. The subgroup analysis by ethnicity showed that G241R polymorphism was significantly associated with cancer risk in European subgroup.

Conclusion: ICAM-1 G241R polymorphism might be associated with cancer risk, especially in European populations, but the results doesn't support ICAM-1 K469E polymorphism as a risk factor for cancer.

No MeSH data available.


Related in: MedlinePlus

Flow chart showing study selection procedure
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Related In: Results  -  Collection


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Figure 1: Flow chart showing study selection procedure

Mentions: The flow chart that displays the study selection process was shown in Fig. 1. In accordance with the inclusion criteria, 16 articles containing 18 case-control studies were included in the meta-analysis, including 4,844 cancer cases and 5,618 healthy controls. There were 18 case-control studies concerning ICAM-1 K469E polymorphism (15–17, 24–35), and 6 case-control studies concerning ICAM-1 G241R (24, 27–30, 33). For ICAM-1 K469E polymorphism, seven studies were conducted in European populations, six in Asian populations, four in America populations, and one in Oceania populations. Moreover, there were four studies of European populations (28–30, 33), one study of Asian populations (24), and one study of America populations (27) for ICAM-1 G241R polymorphism. The genotype distributions among the controls of all studies were in agreement with HWE except for two studies for K469E (27, 31) and one study for G241R (33). The detailed characteristics of the eligible studies included in this meta-analysis were shown in Table 1.


Intercellular Adhesion Molecule-1 (ICAM-1) Polymorphisms and Cancer Risk: A Meta-Analysis.

Cheng D, Liang B - Iran. J. Public Health (2015)

Flow chart showing study selection procedure
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4537618&req=5

Figure 1: Flow chart showing study selection procedure
Mentions: The flow chart that displays the study selection process was shown in Fig. 1. In accordance with the inclusion criteria, 16 articles containing 18 case-control studies were included in the meta-analysis, including 4,844 cancer cases and 5,618 healthy controls. There were 18 case-control studies concerning ICAM-1 K469E polymorphism (15–17, 24–35), and 6 case-control studies concerning ICAM-1 G241R (24, 27–30, 33). For ICAM-1 K469E polymorphism, seven studies were conducted in European populations, six in Asian populations, four in America populations, and one in Oceania populations. Moreover, there were four studies of European populations (28–30, 33), one study of Asian populations (24), and one study of America populations (27) for ICAM-1 G241R polymorphism. The genotype distributions among the controls of all studies were in agreement with HWE except for two studies for K469E (27, 31) and one study for G241R (33). The detailed characteristics of the eligible studies included in this meta-analysis were shown in Table 1.

Bottom Line: However, the results of previous studies are inconsistent.AA) in European subgroup, respectively.The subgroup analysis by ethnicity showed that G241R polymorphism was significantly associated with cancer risk in European subgroup.

View Article: PubMed Central - PubMed

Affiliation: Dept. of Transfusion, The First Hospital of China Medical University, Shenyang, P.R. China.

ABSTRACT

Background: Intercellular adhesion molecule-1 (ICAM-1) Lys469Glu (K469E) polymorphism and Gly 241Arg (G241R) polymorphism might play important roles in cancer development and progression. However, the results of previous studies are inconsistent. The aim of this study was to evaluate the association between ICAM-1 K469E and G241R polymorphisms and the risk of cancer by meta-analysis.

Methods: A comprehensive literature search (last search updated in November 2013) was conducted to identify case-control studies that investigated the association between ICAM-1 K469E and G241R polymorphisms and cancer risk.

Results: A total of 18 case-control studies for ICAM-1 polymorphisms were included in the meta-analysis, including 4,844 cancer cases and 5,618 healthy controls. For K469E polymorphism, no significant association was found between K469E polymorphism and cancer risk. However, subgroup analysis by ethnicity revealed one genetic comparison (GG vs. AA) presented the relationship with cancer risk in Asian subgroup, and two genetic models (GG+GA vs. AA and GA vs. AA) in European subgroup, respectively. For G241R polymorphism, G241R polymorphism was significantly association with cancer risk in overall analysis. The subgroup analysis by ethnicity showed that G241R polymorphism was significantly associated with cancer risk in European subgroup.

Conclusion: ICAM-1 G241R polymorphism might be associated with cancer risk, especially in European populations, but the results doesn't support ICAM-1 K469E polymorphism as a risk factor for cancer.

No MeSH data available.


Related in: MedlinePlus