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The Healing Effect of Arnebia Euchroma Ointment versus Silver Sulfadiazine on Burn Wounds in Rat.

Nasiri E, Hosseinimehr SJ, Azadbakht M, Akbari J, Enayati-Fard R, Azizi S, Azadbakht M - World J Plast Surg (2015)

Bottom Line: Wound size was significantly lower in 10% AEO than 1% SSD and control groups on the 10(th) day post-burn injury.On day 11, the percentage of wound contraction in 5% and 10% AEO was 53.9%±14.7% and 55.9±10.5% which was more than 1% SSD (15.3±10.8%).The collagen fibers were well formed and horizontally-oriented in 5% and 10% AEO groups when compared with other groups.

View Article: PubMed Central - PubMed

Affiliation: Traditional and Complementary Medicine Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran;

ABSTRACT

Background: Burn is still a majordevastating condition in emergency medicine departments among both genders and all age groups in all developed and developing countries, leading to physical, psychological scars and economical burden. The present study aimed to determine the healing effect of topical treatment with Arnebia euchroma on second-degree burn wound in rats.

Methods: Fifty rats were divided into 4 equal groups receiving the ointment base, normal saline (NS), standard 1% silver sulfadiazine (SSD), and 5% and 10% Arnebia euchroma ointments (AEO). The mean of burn area, percentage of wound contraction, histopathological and bacteriological assessments in the injured area were dtermined during the study.

Results: Average area of wound on the 10(th) day was 10.2±2.3, 8.4±2.6, 12.4±2.5, 5.9±2.2 and 5.7±2 cm(2) for ointment base, NS, 1% SSD, and 5% and 10% AEO, respectively. Wound size was significantly lower in 10% AEO than 1% SSD and control groups on the 10(th) day post-burn injury. On day 11, the percentage of wound contraction in 5% and 10% AEO was 53.9%±14.7% and 55.9±10.5% which was more than 1% SSD (15.3±10.8%). The collagen fibers were well formed and horizontally-oriented in 5% and 10% AEO groups when compared with other groups.

Conclusion: Arnebia euchroma ointment was an effective treatment for healing of burn wounds in comparison with SSD and can be regarded as an alternative topical treatment for burn wounds.

No MeSH data available.


Related in: MedlinePlus

Comparison of the percentage of wound contraction between Arnebia euchroma and other groups. 5 and 10% Arnebia euchroma ointment showed a faster wound contraction
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Figure 1: Comparison of the percentage of wound contraction between Arnebia euchroma and other groups. 5 and 10% Arnebia euchroma ointment showed a faster wound contraction

Mentions: The wound area was not significantly difference between control groups (1% SSD, ointment base and NS) on the 10th day of post-burn injury. The difference was significant between 5 and 10% AEO and SSD. No significant difference was noticed regarding the wound size between 5 and 10% AEO treated groups on 10th and 15th days after burn injury. The percentage of wound contraction in different groups was shown in Table 4 showing a significant increase in the 5 and 10% AEO groups when compared to the control group. Animals receiving 1% SSD ointment had a longer healing time in comparison to rats in the AEO treatment groups. These findings were shown in Figure 1. It is clear that wound contraction started from day 5 in all groups, which was faster in the 5 and 10% AEO groups as compared to the control group. On day 7, animals treated with 10% AEO exhibited significant increase in the percentage of wound contraction as compared to other experimental groups (29.7% in 10% AEO as compared to 3.4% in SSD, 14.4% in ointment base and 16.2% in NS groups).


The Healing Effect of Arnebia Euchroma Ointment versus Silver Sulfadiazine on Burn Wounds in Rat.

Nasiri E, Hosseinimehr SJ, Azadbakht M, Akbari J, Enayati-Fard R, Azizi S, Azadbakht M - World J Plast Surg (2015)

Comparison of the percentage of wound contraction between Arnebia euchroma and other groups. 5 and 10% Arnebia euchroma ointment showed a faster wound contraction
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4537605&req=5

Figure 1: Comparison of the percentage of wound contraction between Arnebia euchroma and other groups. 5 and 10% Arnebia euchroma ointment showed a faster wound contraction
Mentions: The wound area was not significantly difference between control groups (1% SSD, ointment base and NS) on the 10th day of post-burn injury. The difference was significant between 5 and 10% AEO and SSD. No significant difference was noticed regarding the wound size between 5 and 10% AEO treated groups on 10th and 15th days after burn injury. The percentage of wound contraction in different groups was shown in Table 4 showing a significant increase in the 5 and 10% AEO groups when compared to the control group. Animals receiving 1% SSD ointment had a longer healing time in comparison to rats in the AEO treatment groups. These findings were shown in Figure 1. It is clear that wound contraction started from day 5 in all groups, which was faster in the 5 and 10% AEO groups as compared to the control group. On day 7, animals treated with 10% AEO exhibited significant increase in the percentage of wound contraction as compared to other experimental groups (29.7% in 10% AEO as compared to 3.4% in SSD, 14.4% in ointment base and 16.2% in NS groups).

Bottom Line: Wound size was significantly lower in 10% AEO than 1% SSD and control groups on the 10(th) day post-burn injury.On day 11, the percentage of wound contraction in 5% and 10% AEO was 53.9%±14.7% and 55.9±10.5% which was more than 1% SSD (15.3±10.8%).The collagen fibers were well formed and horizontally-oriented in 5% and 10% AEO groups when compared with other groups.

View Article: PubMed Central - PubMed

Affiliation: Traditional and Complementary Medicine Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran;

ABSTRACT

Background: Burn is still a majordevastating condition in emergency medicine departments among both genders and all age groups in all developed and developing countries, leading to physical, psychological scars and economical burden. The present study aimed to determine the healing effect of topical treatment with Arnebia euchroma on second-degree burn wound in rats.

Methods: Fifty rats were divided into 4 equal groups receiving the ointment base, normal saline (NS), standard 1% silver sulfadiazine (SSD), and 5% and 10% Arnebia euchroma ointments (AEO). The mean of burn area, percentage of wound contraction, histopathological and bacteriological assessments in the injured area were dtermined during the study.

Results: Average area of wound on the 10(th) day was 10.2±2.3, 8.4±2.6, 12.4±2.5, 5.9±2.2 and 5.7±2 cm(2) for ointment base, NS, 1% SSD, and 5% and 10% AEO, respectively. Wound size was significantly lower in 10% AEO than 1% SSD and control groups on the 10(th) day post-burn injury. On day 11, the percentage of wound contraction in 5% and 10% AEO was 53.9%±14.7% and 55.9±10.5% which was more than 1% SSD (15.3±10.8%). The collagen fibers were well formed and horizontally-oriented in 5% and 10% AEO groups when compared with other groups.

Conclusion: Arnebia euchroma ointment was an effective treatment for healing of burn wounds in comparison with SSD and can be regarded as an alternative topical treatment for burn wounds.

No MeSH data available.


Related in: MedlinePlus