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Repeated measures of inflammation, blood pressure, and heart rate variability associated with traffic exposures in healthy adults.

Mirowsky JE, Peltier RE, Lippmann M, Thurston G, Chen LC, Neas L, Diaz-Sanchez D, Laumbach R, Carter JD, Gordon T - Environ Health (2015)

Bottom Line: Mixed effect models were used to assess changes in health effects associated with these specific pollutant classes.Small decreases in BP measurements and rMSSD, and increases in IL-1β and the low frequency to high frequency ratio measured in HRV, were observed with increasing concentrations of PM2.5 EC.The associations were most profound with the diesel-source EC.

View Article: PubMed Central - PubMed

Affiliation: Department of Environmental Medicine, New York University, Tuxedo, NY, USA. mirowsky@email.unc.edu.

ABSTRACT

Background: Previous human exposure studies of traffic-related air pollutants have demonstrated adverse health effects in human populations by comparing areas of high and low traffic, but few studies have utilized microenvironmental monitoring of pollutants at multiple traffic locations while looking at a vast array of health endpoints in the same population. We evaluated inflammatory markers, heart rate variability (HRV), blood pressure, exhaled nitric oxide, and lung function in healthy participants after exposures to varying mixtures of traffic pollutants.

Methods: A repeated-measures, crossover study design was used in which 23 healthy, non-smoking adults had clinical cardiopulmonary and systemic inflammatory measurements taken prior to, immediately after, and 24 hours after intermittent walking for two hours in the summer months along three diverse roadways having unique emission characteristics. Measurements of PM2.5, PM10, black carbon (BC), elemental carbon (EC), and organic carbon (OC) were collected. Mixed effect models were used to assess changes in health effects associated with these specific pollutant classes.

Results: Minimal associations were observed with lung function measurements and the pollutants measured. Small decreases in BP measurements and rMSSD, and increases in IL-1β and the low frequency to high frequency ratio measured in HRV, were observed with increasing concentrations of PM2.5 EC.

Conclusions: Small, acute changes in cardiovascular and inflammation-related effects of microenvironmental exposures to traffic-related air pollution were observed in a group of healthy young adults. The associations were most profound with the diesel-source EC.

No MeSH data available.


Related in: MedlinePlus

Percent changes in a eNO, b IL-1 β, c ICAM, d SBP, e PP, f HF, g LF:HF, h HR at SF, GSP, and GWB for post- and 24 h measurements, compared to pre-exposure measurements. Health outcomes were analyzed using a repeated-measures ANOVA to assess statistical significance between locations, followed by a Student Newman-Keul’s post hoc test. Values represent mean ± SE. *p value < 0.05
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Fig1: Percent changes in a eNO, b IL-1 β, c ICAM, d SBP, e PP, f HF, g LF:HF, h HR at SF, GSP, and GWB for post- and 24 h measurements, compared to pre-exposure measurements. Health outcomes were analyzed using a repeated-measures ANOVA to assess statistical significance between locations, followed by a Student Newman-Keul’s post hoc test. Values represent mean ± SE. *p value < 0.05

Mentions: Health effects were assessed both using a site-by-site comparison and a mixed effect model for pollution and location. When analyzed on a site-by-site basis (Fig. 1), lung function measurements did not differ between locations (Additional file 2). However, an approximate 5 % increase in eNO was observed at the GWB post exposure, whereas all other measurements of eNO were decreased, when compared to pre-exposure values. However, the increase at the GWB was not statistically significant (p = 0.13).Fig. 1


Repeated measures of inflammation, blood pressure, and heart rate variability associated with traffic exposures in healthy adults.

Mirowsky JE, Peltier RE, Lippmann M, Thurston G, Chen LC, Neas L, Diaz-Sanchez D, Laumbach R, Carter JD, Gordon T - Environ Health (2015)

Percent changes in a eNO, b IL-1 β, c ICAM, d SBP, e PP, f HF, g LF:HF, h HR at SF, GSP, and GWB for post- and 24 h measurements, compared to pre-exposure measurements. Health outcomes were analyzed using a repeated-measures ANOVA to assess statistical significance between locations, followed by a Student Newman-Keul’s post hoc test. Values represent mean ± SE. *p value < 0.05
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4537534&req=5

Fig1: Percent changes in a eNO, b IL-1 β, c ICAM, d SBP, e PP, f HF, g LF:HF, h HR at SF, GSP, and GWB for post- and 24 h measurements, compared to pre-exposure measurements. Health outcomes were analyzed using a repeated-measures ANOVA to assess statistical significance between locations, followed by a Student Newman-Keul’s post hoc test. Values represent mean ± SE. *p value < 0.05
Mentions: Health effects were assessed both using a site-by-site comparison and a mixed effect model for pollution and location. When analyzed on a site-by-site basis (Fig. 1), lung function measurements did not differ between locations (Additional file 2). However, an approximate 5 % increase in eNO was observed at the GWB post exposure, whereas all other measurements of eNO were decreased, when compared to pre-exposure values. However, the increase at the GWB was not statistically significant (p = 0.13).Fig. 1

Bottom Line: Mixed effect models were used to assess changes in health effects associated with these specific pollutant classes.Small decreases in BP measurements and rMSSD, and increases in IL-1β and the low frequency to high frequency ratio measured in HRV, were observed with increasing concentrations of PM2.5 EC.The associations were most profound with the diesel-source EC.

View Article: PubMed Central - PubMed

Affiliation: Department of Environmental Medicine, New York University, Tuxedo, NY, USA. mirowsky@email.unc.edu.

ABSTRACT

Background: Previous human exposure studies of traffic-related air pollutants have demonstrated adverse health effects in human populations by comparing areas of high and low traffic, but few studies have utilized microenvironmental monitoring of pollutants at multiple traffic locations while looking at a vast array of health endpoints in the same population. We evaluated inflammatory markers, heart rate variability (HRV), blood pressure, exhaled nitric oxide, and lung function in healthy participants after exposures to varying mixtures of traffic pollutants.

Methods: A repeated-measures, crossover study design was used in which 23 healthy, non-smoking adults had clinical cardiopulmonary and systemic inflammatory measurements taken prior to, immediately after, and 24 hours after intermittent walking for two hours in the summer months along three diverse roadways having unique emission characteristics. Measurements of PM2.5, PM10, black carbon (BC), elemental carbon (EC), and organic carbon (OC) were collected. Mixed effect models were used to assess changes in health effects associated with these specific pollutant classes.

Results: Minimal associations were observed with lung function measurements and the pollutants measured. Small decreases in BP measurements and rMSSD, and increases in IL-1β and the low frequency to high frequency ratio measured in HRV, were observed with increasing concentrations of PM2.5 EC.

Conclusions: Small, acute changes in cardiovascular and inflammation-related effects of microenvironmental exposures to traffic-related air pollution were observed in a group of healthy young adults. The associations were most profound with the diesel-source EC.

No MeSH data available.


Related in: MedlinePlus