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Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation.

Tremaroli V, Karlsson F, Werling M, Ståhlman M, Kovatcheva-Datchary P, Olbers T, Fändriks L, le Roux CW, Nielsen J, Bäckhed F - Cell Metab. (2015)

Bottom Line: The two surgical procedures induced similar and durable changes on the gut microbiome that were not dependent on body mass index and resulted in altered levels of fecal and circulating metabolites compared with obese controls.By colonizing germ-free mice with stools from the patients, we demonstrated that the surgically altered microbiota promoted reduced fat deposition in recipient mice.These mice also had a lower respiratory quotient, indicating decreased utilization of carbohydrates as fuel.

View Article: PubMed Central - PubMed

Affiliation: The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, SE-413 45 Gothenburg, Sweden.

No MeSH data available.


Related in: MedlinePlus

Functional Differences in the Microbiomes of RYGB, VBG and OBS Subjects as Measured by the Abundance of KOs(A) Comparison of RYGB versus OBS samples.(B) Comparison of VBG versus OBS samples.(C) Comparison of RYGB versus VBG samples.Each spot represents a KO, and red spots represent KOs whose abundance is significantly different. FC, fold change; CPM, counts per million. See also Table S4 and Figures S1 and S2.
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fig2: Functional Differences in the Microbiomes of RYGB, VBG and OBS Subjects as Measured by the Abundance of KOs(A) Comparison of RYGB versus OBS samples.(B) Comparison of VBG versus OBS samples.(C) Comparison of RYGB versus VBG samples.Each spot represents a KO, and red spots represent KOs whose abundance is significantly different. FC, fold change; CPM, counts per million. See also Table S4 and Figures S1 and S2.

Mentions: We observed differences in the microbiome of operated and non-operated severely obese women (Figure 2; Table S4): 928 KOs were enriched and 60 were depleted in RYGB versus OBS samples (Figure 2A; Table S4), while 682 KOs were enriched and 33 were depleted in VBG versus OBS samples (Figure 2B; Table S4). However, only 17 KOs were differentially abundant between RYGB and VBG samples, all enriched in VBG (Figure 2C; Table S4).


Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation.

Tremaroli V, Karlsson F, Werling M, Ståhlman M, Kovatcheva-Datchary P, Olbers T, Fändriks L, le Roux CW, Nielsen J, Bäckhed F - Cell Metab. (2015)

Functional Differences in the Microbiomes of RYGB, VBG and OBS Subjects as Measured by the Abundance of KOs(A) Comparison of RYGB versus OBS samples.(B) Comparison of VBG versus OBS samples.(C) Comparison of RYGB versus VBG samples.Each spot represents a KO, and red spots represent KOs whose abundance is significantly different. FC, fold change; CPM, counts per million. See also Table S4 and Figures S1 and S2.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4537510&req=5

fig2: Functional Differences in the Microbiomes of RYGB, VBG and OBS Subjects as Measured by the Abundance of KOs(A) Comparison of RYGB versus OBS samples.(B) Comparison of VBG versus OBS samples.(C) Comparison of RYGB versus VBG samples.Each spot represents a KO, and red spots represent KOs whose abundance is significantly different. FC, fold change; CPM, counts per million. See also Table S4 and Figures S1 and S2.
Mentions: We observed differences in the microbiome of operated and non-operated severely obese women (Figure 2; Table S4): 928 KOs were enriched and 60 were depleted in RYGB versus OBS samples (Figure 2A; Table S4), while 682 KOs were enriched and 33 were depleted in VBG versus OBS samples (Figure 2B; Table S4). However, only 17 KOs were differentially abundant between RYGB and VBG samples, all enriched in VBG (Figure 2C; Table S4).

Bottom Line: The two surgical procedures induced similar and durable changes on the gut microbiome that were not dependent on body mass index and resulted in altered levels of fecal and circulating metabolites compared with obese controls.By colonizing germ-free mice with stools from the patients, we demonstrated that the surgically altered microbiota promoted reduced fat deposition in recipient mice.These mice also had a lower respiratory quotient, indicating decreased utilization of carbohydrates as fuel.

View Article: PubMed Central - PubMed

Affiliation: The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, SE-413 45 Gothenburg, Sweden.

No MeSH data available.


Related in: MedlinePlus