Limits...
Chemistry Central Journal themed issue: Dial-a-Molecule.

Kilpin KJ, Whitby RJ - Chem Cent J (2015)

View Article: PubMed Central - PubMed

Affiliation: Chemistry, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, SO17 1BJ UK.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

When you consider that these machines work with well-defined, structurally similar building blocks, using the same chemistry to link them, the enormity of the Grand Challenge becomes clear... The benefits of being able to ‘dial-up’ any molecule will be immense, and reach far beyond the traditional chemistry end-users (e.g. the pharma industry)... Ultimately, many emerging sectors such as (but not limited to) sustainable new materials, next generation electronics, healthcare and forensics, will benefit... Working towards achieving the Grand Challenge, the Dial-a-Molecule Network developed the Roadmap for Chemical Synthesis in the 21st century... By breaking the Grand Challenge down into three inter-related themes (see Fig.  1 for a graphical representation, and below for a brief summary) the Roadmap defines the state of the art and identifies the gaps, opportunities and key actions to help guide research towards the realisation of the Dial-a-Molecule vision... This theme is subdivided into four areas:Optimum reaction and route design describes how the optimum synthetic routes can be selected the first time by making use of data to predict the outcome of unknown reactions... Taking these factors into account, two approaches were identified to gain access to any molecule at will:Stepwise perfection (1,000 click reactions) If the synthetic chemist has access to enough perfect and reliable reactions, most complex molecules could be obtained in a step-wise, ‘clickable’ manner... Of the academics, almost half are not synthetic organic chemists... As a community, Dial-a-Molecule has run a number of meetings to discuss themes relevant to advancing the Roadmap, and through commissioned research projects has made significant inroads towards achieving many of the near and medium term goals... An extremely positive aspect is the community continues to grow, and the enthusiasm demonstrated by the next generation of researchers indicates that the research efforts towards achieving the aims of the Grand Challenge is in safe hands going forward... This special edition in Chemistry Central Journal serves to highlight some of the recent efforts directed towards achieving the goals set out in the Roadmap.

No MeSH data available.


Key challenges identified in the Dial-a-Molecule Roadmap for Chemical Synthesis in the 21st century.
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4537488&req=5

Fig1: Key challenges identified in the Dial-a-Molecule Roadmap for Chemical Synthesis in the 21st century.

Mentions: By breaking the Grand Challenge down into three inter-related themes (see Fig. 1 for a graphical representation, and below for a brief summary) the Roadmap defines the state of the art and identifies the gaps, opportunities and key actions to help guide research towards the realisation of the Dial-a-Molecule vision. The Roadmap is available to download at http://www.dial-a-molecule.org/roadmap.Fig. 1


Chemistry Central Journal themed issue: Dial-a-Molecule.

Kilpin KJ, Whitby RJ - Chem Cent J (2015)

Key challenges identified in the Dial-a-Molecule Roadmap for Chemical Synthesis in the 21st century.
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4537488&req=5

Fig1: Key challenges identified in the Dial-a-Molecule Roadmap for Chemical Synthesis in the 21st century.
Mentions: By breaking the Grand Challenge down into three inter-related themes (see Fig. 1 for a graphical representation, and below for a brief summary) the Roadmap defines the state of the art and identifies the gaps, opportunities and key actions to help guide research towards the realisation of the Dial-a-Molecule vision. The Roadmap is available to download at http://www.dial-a-molecule.org/roadmap.Fig. 1

View Article: PubMed Central - PubMed

Affiliation: Chemistry, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, SO17 1BJ UK.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

When you consider that these machines work with well-defined, structurally similar building blocks, using the same chemistry to link them, the enormity of the Grand Challenge becomes clear... The benefits of being able to ‘dial-up’ any molecule will be immense, and reach far beyond the traditional chemistry end-users (e.g. the pharma industry)... Ultimately, many emerging sectors such as (but not limited to) sustainable new materials, next generation electronics, healthcare and forensics, will benefit... Working towards achieving the Grand Challenge, the Dial-a-Molecule Network developed the Roadmap for Chemical Synthesis in the 21st century... By breaking the Grand Challenge down into three inter-related themes (see Fig.  1 for a graphical representation, and below for a brief summary) the Roadmap defines the state of the art and identifies the gaps, opportunities and key actions to help guide research towards the realisation of the Dial-a-Molecule vision... This theme is subdivided into four areas:Optimum reaction and route design describes how the optimum synthetic routes can be selected the first time by making use of data to predict the outcome of unknown reactions... Taking these factors into account, two approaches were identified to gain access to any molecule at will:Stepwise perfection (1,000 click reactions) If the synthetic chemist has access to enough perfect and reliable reactions, most complex molecules could be obtained in a step-wise, ‘clickable’ manner... Of the academics, almost half are not synthetic organic chemists... As a community, Dial-a-Molecule has run a number of meetings to discuss themes relevant to advancing the Roadmap, and through commissioned research projects has made significant inroads towards achieving many of the near and medium term goals... An extremely positive aspect is the community continues to grow, and the enthusiasm demonstrated by the next generation of researchers indicates that the research efforts towards achieving the aims of the Grand Challenge is in safe hands going forward... This special edition in Chemistry Central Journal serves to highlight some of the recent efforts directed towards achieving the goals set out in the Roadmap.

No MeSH data available.