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Conversational Interaction in the Scanner: Mentalizing during Language Processing as Revealed by MEG.

Bögels S, Barr DJ, Garrod S, Kessler K - Cereb. Cortex (2014)

Bottom Line: Our analysis of the neural processing of test phase utterances revealed recruitment of neural circuits associated with language (temporal cortex), episodic memory (e.g., medial temporal lobe), and mentalizing (temporo-parietal junction and ventromedial prefrontal cortex).The episodic memory and language circuits were recruited in anticipation of upcoming referring expressions, suggesting that context-sensitive predictions were spontaneously generated.In contrast, the mentalizing areas were recruited on-demand, as a means for detecting and resolving perceived pragmatic anomalies, with little evidence they were activated to make partner-specific predictions about upcoming linguistic utterances.

View Article: PubMed Central - PubMed

Affiliation: Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK.

No MeSH data available.


Related in: MedlinePlus

Theta phase-coherence (4–6 Hz) localized for the post-naming interval by means of DICS (see Methods). Differences in coherent sources between same-speaker, precedent mismatch minus same-speaker, no precedent (FDR-corrected significant t-values) in reference to theta-power sources in latPFC, left TP, left mTC, right PHG, and right TPJ as identified in the reported power analyses (see Fig. 4). The color-coded scale represents t-values. New source labels in this figure are ACC, anterior cingulate cortex; SMA, supplementary motor area. For all other source labels, see Figure 4. Red-yellow sources denote stronger coherence in the same-speaker, precedent mismatch compared with the same-speaker, no precedent condition, whereas blue sources denote the opposite effect. Further explanations in the text and Supplementary Table S3.
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BHU116F6: Theta phase-coherence (4–6 Hz) localized for the post-naming interval by means of DICS (see Methods). Differences in coherent sources between same-speaker, precedent mismatch minus same-speaker, no precedent (FDR-corrected significant t-values) in reference to theta-power sources in latPFC, left TP, left mTC, right PHG, and right TPJ as identified in the reported power analyses (see Fig. 4). The color-coded scale represents t-values. New source labels in this figure are ACC, anterior cingulate cortex; SMA, supplementary motor area. For all other source labels, see Figure 4. Red-yellow sources denote stronger coherence in the same-speaker, precedent mismatch compared with the same-speaker, no precedent condition, whereas blue sources denote the opposite effect. Further explanations in the text and Supplementary Table S3.

Mentions: To obtain a picture of the functional connectivity between these various brain areas, we analyzed phase-coherence in the 4–6 Hz band between 200 and 800 ms post-naming (see Methods). We contrasted precedent mismatch and no precedent conditions for the same speaker to identify cortical areas that revealed coherence differences relative to a particular reference site. The overall pattern of coherence is shown in detail in Figure 6 (and Supplementary Table S3) and reveals functional connectivity effects (statistical maps of significant theta phase-coherence effects) in relation to “seed” areas (reference sites) taken from the previous theta-power source analyses. Red color denotes areas that are coupled significantly stronger with the respective seed area in the mismatch compared with the no-precedent condition (mismatch > no precedent), whereas blue color denotes the reverse effect (mismatch < no precedent).Figure 6.


Conversational Interaction in the Scanner: Mentalizing during Language Processing as Revealed by MEG.

Bögels S, Barr DJ, Garrod S, Kessler K - Cereb. Cortex (2014)

Theta phase-coherence (4–6 Hz) localized for the post-naming interval by means of DICS (see Methods). Differences in coherent sources between same-speaker, precedent mismatch minus same-speaker, no precedent (FDR-corrected significant t-values) in reference to theta-power sources in latPFC, left TP, left mTC, right PHG, and right TPJ as identified in the reported power analyses (see Fig. 4). The color-coded scale represents t-values. New source labels in this figure are ACC, anterior cingulate cortex; SMA, supplementary motor area. For all other source labels, see Figure 4. Red-yellow sources denote stronger coherence in the same-speaker, precedent mismatch compared with the same-speaker, no precedent condition, whereas blue sources denote the opposite effect. Further explanations in the text and Supplementary Table S3.
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Related In: Results  -  Collection

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BHU116F6: Theta phase-coherence (4–6 Hz) localized for the post-naming interval by means of DICS (see Methods). Differences in coherent sources between same-speaker, precedent mismatch minus same-speaker, no precedent (FDR-corrected significant t-values) in reference to theta-power sources in latPFC, left TP, left mTC, right PHG, and right TPJ as identified in the reported power analyses (see Fig. 4). The color-coded scale represents t-values. New source labels in this figure are ACC, anterior cingulate cortex; SMA, supplementary motor area. For all other source labels, see Figure 4. Red-yellow sources denote stronger coherence in the same-speaker, precedent mismatch compared with the same-speaker, no precedent condition, whereas blue sources denote the opposite effect. Further explanations in the text and Supplementary Table S3.
Mentions: To obtain a picture of the functional connectivity between these various brain areas, we analyzed phase-coherence in the 4–6 Hz band between 200 and 800 ms post-naming (see Methods). We contrasted precedent mismatch and no precedent conditions for the same speaker to identify cortical areas that revealed coherence differences relative to a particular reference site. The overall pattern of coherence is shown in detail in Figure 6 (and Supplementary Table S3) and reveals functional connectivity effects (statistical maps of significant theta phase-coherence effects) in relation to “seed” areas (reference sites) taken from the previous theta-power source analyses. Red color denotes areas that are coupled significantly stronger with the respective seed area in the mismatch compared with the no-precedent condition (mismatch > no precedent), whereas blue color denotes the reverse effect (mismatch < no precedent).Figure 6.

Bottom Line: Our analysis of the neural processing of test phase utterances revealed recruitment of neural circuits associated with language (temporal cortex), episodic memory (e.g., medial temporal lobe), and mentalizing (temporo-parietal junction and ventromedial prefrontal cortex).The episodic memory and language circuits were recruited in anticipation of upcoming referring expressions, suggesting that context-sensitive predictions were spontaneously generated.In contrast, the mentalizing areas were recruited on-demand, as a means for detecting and resolving perceived pragmatic anomalies, with little evidence they were activated to make partner-specific predictions about upcoming linguistic utterances.

View Article: PubMed Central - PubMed

Affiliation: Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK.

No MeSH data available.


Related in: MedlinePlus